“…Indeed, our study results show that in the high-risk group (GRADE > 8), patients were older, more dependent, had higher ASA and ECOG-PS scores, a more frequently abnormal G8-index, and greater cognitive impairment. Over the post-operative period ranging from 6 months to 7 years, all of these pre-operative factors are known to be associated with poorer survival among older patients undergoing major cancer surgery [ 10 , 27 , 28 , 29 , 30 , 31 ]. However, the GRADE score remains independently associated with 5-year mortality after adjustment for IADL-dependency and malnutrition (BMI < 21 kg/m 2 ).…”