Endoscopic ultrasonography (EUS) is unstoppably entering our Units' endoscopic armamentarium. The usefulness of this technique for patients with cancer or otherwise is increasing with an ongoing refinement of accuracy and a continuous expansion towards a varied therapeutic range. Being a mixed endoscopic and sonographic technique, EUS also benefits from advances such as Doppler, contrast enhancement, and elastography. Basically, EUS-related hardware may include radial and sectorial instruments as well as miniprobes; the latter are used through the working channels of various endoscopes, and may even enter the biliary tract (BT) in selected cases. Today, for instance, a miniprobe may be passed down a therapeutic enteroscope in complex situations to explore the BT following a Roux-en-Y intestinal procedure. The ability to take the full potential of ultrasounds to the gut wall site nearest a lesion to be assessed provides the best approach possible, that is, an intraluminal approach using endoscopic instruments.The BT may be explored with conventional abdominal ultrasounds, which represent the basic procedure and harmless initial exam for these patients. Already in this initial step whether dilating or not the intra-or extra-hepatic BT will guide a clinician's decisions, and that is why bedside sonography without delay, as suggested by Segura et al.(1), discriminates early management and in many centers guides patient admission. BT conditions involve a highly variable anatomical and morphological substrate, and their diagnosis and appropriate management are challenging: endoscopy, surgery or radiography combined with a comprehensive, mutidisciplinary approach to the underlying disease. In addition to such variation, also of interest for surgical treatment, the BT is a dynamic structure, and stones may be located at different sites or spontaneously expelled, a minor dilation may be seen when the sustaining parenchyma develops fibrosis (cirrhosis), a postural change may displace bile stones, etc. Time is highly relevant in the BT, and its correlation to clinical manifestations is vital.Regarding diagnosis for BT diseases, another non-invasive technique to consider after abdominal US in the diagnostic algorithm is magnetic resonance cholangiography (MRC), which renders a rather reliable map of the BT, although with both technical (patient movement, metallic objects, sedation needed at times) and accuracy-related issues (small stones, short stenoses). Of course, endoscopic retrograde cholangio-pancreatography (ERCP) is superior to MRC in image quality given its dynamic contrast and action on the biliary tree (for example, with Fogarty balloon filling to better delimit a proximal area), thus better detecting extravasation, fistulas, etc.; however, ERCP has non-negligible complications and should be restricted for therapy. Hence, ERCP is -except for urgent cases such as serious cholangitis, etc.-a second-line technique following high diagnostic suspicion as a result of another non-invasive technique. EUS, however, is min...