Usefulness of fatty meal-stimulated cholescintigraphy in the diagnosis and treatment of chronic acalculous cholecystitis

Al-Muqbel, Kusai M.; Hani, Mohammed Bani; Daradkeh, Mohammad S.; Rashdan, Abdullah

doi:10.1007/s12149-008-0221-5

Cited by 18 publications

(28 citation statements)

References 23 publications

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“…The main utility of cholescintigraphy is in the confirmation or exclusion of CAC in patients who have a high clinical suspicion of CAC [1][2][3][4][13][14][15]. Gallbladder emptying has several variables, including latent period, GBEF, and patterns of gallbladder emptying [5].…”

Section: Discussionmentioning

confidence: 99%

“…Measurement of gallbladder ejection fraction (GBEF) by cholescintigraphy (CS) is considered the test of choice for confirming the diagnosis of chronic acalculous cholecystitis (CAC) [1][2][3][4]. Gallbladder emptying has several variables, including latent period, GBEF, and patterns of gallbladder emptying [5].…”

Section: Introductionmentioning

confidence: 99%

“…However, GBEF is the single most important gallbladder emptying variable in the diagnosis of CAC [5]. Low GBEF is the main abnormal finding upon which the diagnosis of CAC is usually confirmed [1][2][3][4][5]. Cholecystokinin (CCK) is widely used cholagogue stimulant to induce gallbladder contraction in CS [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…Low GBEF is the main abnormal finding upon which the diagnosis of CAC is usually confirmed [1][2][3][4][5]. Cholecystokinin (CCK) is widely used cholagogue stimulant to induce gallbladder contraction in CS [1][2][3][4]. Several investigators have found a fatty meal to be a physiologic, easy to handle and cheap alternative to CCK to induce gallbladder contraction in CS [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Cholecystokinin (CCK) is widely used cholagogue stimulant to induce gallbladder contraction in CS [1][2][3][4]. Several investigators have found a fatty meal to be a physiologic, easy to handle and cheap alternative to CCK to induce gallbladder contraction in CS [4][5][6][7][8]. There are limited and conflicting data in the literature regarding the reproducibility of GBEF measured by fatty meal CS.…”

Section: Introductionmentioning

confidence: 99%

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Reproducibility of Gallbladder Ejection Fraction Measured by Fatty Meal Cholescintigraphy

Al-Muqbel

Hani

El-Heis

et al. 2010

Nucl Med Mol Imaging

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Purpose There are conflicting data in the literature regarding the reproducibility of the gallbladder ejection fraction (GBEF) measured by fatty meal cholescintigraphy (CS). We aimed to test the reproducibility of GBEF measured by fatty meal CS. Methods Thirty-five subjects (25 healthy volunteers and 10 patients with chronic abdominal pain) underwent fatty meal CS twice in order to measure GBEF1 and GBEF2. The healthy volunteers underwent a repeat scan within 1-13 months from the first scan. The patients underwent a repeat scan within 1-4 years from the first scan and were not found to have chronic acalculous cholecystitis (CAC). Our standard fatty meal was composed of a 60-g Snickers chocolate bar and 200 ml full-fat yogurt. Results The mean ± SD values for GBEF1 and GBEF2 were 52±17% and 52±16%, respectively. There was a direct linear correlation between the values of GBEF1 and GBEF2 for the subjects, with a correlation coefficient of 0.509 (p=0.002). Subgroup data analysis of the volunteer group showed that there was significant linear correlation between volunteer values of GBEF1 and GBEF2, with a correlation coefficient of 0.473 (p=0.017). Subgroup data analysis of the non-CAC patient group showed no significant correlation between patient values of GBEF1 and GBEF2, likely due to limited sample size. Conclusions This study showed that fatty meal CS is a reliable test in gallbladder motility evaluation and that GBEF measured by fatty meal CS is reproducible.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reproducibility of Gallbladder Ejection Fraction Measured by Fatty Meal Cholescintigraphy

Al-Muqbel

Hani

El-Heis

et al. 2010

Nucl Med Mol Imaging

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Diagnostic Stringency and Healthcare Needs in Patients with Biliary Dyskinesia

Aggarwal

Bielefeldt

2013

Dig Dis Sci

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Cholecystectomy for Biliary Dyskinesia: How Did We Get There?

et al. 2014

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Functional gallbladder testing should not be seen as an indicator of relevant biliary tract disease or prognostic marker to identify patients who may benefit from operative intervention. Instead biliary dyskinesia should be considered as a part of a spectrum of functional disorders, which are generally managed conservatively. Small proof of concept studies have demonstrated effects of medical therapy on biliary dysfunction and should thus be never tested in appropriately designed trials.

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Usefulness of fatty meal-stimulated cholescintigraphy in the diagnosis and treatment of chronic acalculous cholecystitis

Abstract: Fatty meal CS is a very useful technique in the diagnosis of CAC. It predicts a good surgical outcome once GBEF is low in patients with high pre-test probability for CAC. Moreover, fatty meal CS may be a good alternative to CCK CS.

Cited by 18 publications

References 23 publications

Reproducibility of Gallbladder Ejection Fraction Measured by Fatty Meal Cholescintigraphy

Reproducibility of Gallbladder Ejection Fraction Measured by Fatty Meal Cholescintigraphy

Diagnostic Stringency and Healthcare Needs in Patients with Biliary Dyskinesia

Cholecystectomy for Biliary Dyskinesia: How Did We Get There?

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