Usefulness of Highly Active Antiretroviral Therapy on Health-Related Quality of Life of Adult Recipients in Tanzania

Magafu, Mgaywa Gilbert Mjungu Damas; Moji, Kazuhiko; Igumbor, Ehimario; Hashizume, Masahiro; Mizota, Tsutomu; Komazawa, Osuke; Cai, Guoxi; Yamamoto, Taro

doi:10.1089/apc.2008.0278

Cited by 16 publications

(23 citation statements)

References 19 publications

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“…As part of routine care, MMT clients were asked to complete a comprehensive baseline survey to collect demographic, drug history, legal history, mental health (depression and anxiety), and HIV risk behavior data. The survey also included the health-related quality of life tool (SF-12) (Ware, Kosinski, & Keller, 1996)which has been previously used and validated in the Tanzanian context (Atkinson, Mccurdy, Williams, Mbwambo, & Kilonzo, 2011; Kaaya et al, 2002; Lee, Kaaya, Mbwambo, Smith-Fawzi, & Leshabari, 2008; Magafu et al, 2009; Wagner et al, 1999; Wyss et al, 1999). The follow-up survey contained the same components and was completed between three to six months after baseline.…”

Section: Methodsmentioning

confidence: 99%

“…In particular, SF-12 has demonstrated excellent reliability and validity in the general population (Ware et al, 1996); among individuals with severe mental illness and substance dependence (Salyers, Bosworth, Swanson, Lamb-Pagone, & Osher, 2000); and among people living with HIV (Chariyalertsak et al, 2011; Delate & Coons, 2000; Han, Pulling, Telke, & Huppler Hullsiek, 2002; Viswanathan, Anderson, & Thomas, 2005; Wu, Hays, Kelly, Malitz, & Bozzette, 1997). The use of the SF-36, from which the SF-12 is based, has also demonstrated validity in Tanzania (Magafu et al, 2009; Wagner et al, 1999; Wyss et al, 1999). Data were collected at baseline and at three to six months follow-up and extracted from the MMT electronic database for analysis.…”

Section: Methodsmentioning

confidence: 99%

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Improvements in health-related quality of life among methadone maintenance clients in Dar es Salaam, Tanzania

Ubuguyu

Tran

Bruce

et al. 2016

International Journal of Drug Policy

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Background Injection of heroin has become widespread in Dar es Salaam, Tanzania and is spreading throughout the country. To prevent potential bridging of HIV epidemics, the Tanzanian government established a methadone maintenance treatment (MMT) clinic in February 2011. We assess the effect of MMT on health-related quality of life (HRQOL) and examine factors, particularly HIV infection and methadone dose, associated with changes in HRQOL. Methods This study utilized routine data on clients enrolling in methadone from February 2011 to April 2012 at Muhimbili National Hospital. Change in physical (PCS) and mental health (MCS) composite scores, as measured by the SF-12 tool, were the primary outcomes. Backward stepwise linear regression, with a criterion of p<0.2 was used to identify baseline exposure variables for inclusion in multivariable models, while adjusting for baseline scores. Results A total of 288 MMT clients received baseline and follow-up assessments. Mean methadone dose administered was 45 mg (SD±25) and 76(27%) were confirmed HIV-positive. Significant improvements were observed in PCS and MCS, with mean increases of 15.7 and 3.3, respectively. In multivariable models, clients who had previous poly-substance use with cocaine [p=0.040] had a significantly higher mean change in PCS. Clients who were living with HIV [p=0.002]; satisfied with current marital situation [p=0.045]; had a history of suicidal thoughts [p=0.021]; and previously experienced cognitive difficulties [p=0.012] had significantly lower mean change in PCS. Clients with shorter history of heroin use [p=0.012] and who received higher methadone doses [p=0.028] had significantly higher mean change in MCS, compared to their counterparts. Discussion Aspects of mental and physical health, risk behaviors and quality of life among drug users are intertwined and complex. Our research revealed positive short-term effects of MMT on HRQOL and highlights the importance of sustained retention for optimal benefits. Comprehensive supportive services in addition to provision of methadone are needed to address the complex health needs of people who inject drugs.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Improvements in health-related quality of life among methadone maintenance clients in Dar es Salaam, Tanzania

Ubuguyu

Tran

Bruce

et al. 2016

International Journal of Drug Policy

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“…1 2 15 16 Over the past decade, increased availability of HAART has substantially improved the quality of life and survival of many children born or infected with HIV/AIDS. [17][18][19] In 2012, the National Aids Control Programme in Tanzania estimated the number of children below the age of 15 years living with HIV at 160 000. 20 21 Sadly, only 58 245 of these children were enrolled in CTCs across the country and HIV/AIDS remains among the top 10 causes of death in children aged <5 years in Tanzania.…”

Section: Discussionmentioning

confidence: 99%

HIV counselling and testing practices for children seen in an urban emergency department of a tertiary referral hospital in Dar es Salaam, Tanzania: a retrospective cross-sectional study

et al. 2016

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ObjectivesTo describe the HIV counselling and testing practices for children presenting to an emergency department (ED) in a low-income country.SettingThe ED of a large east African national referral hospital.ParticipantsThis retrospective review of all paediatric (<18 years old) ED visits in 2012 enrolled patients who had an HIV test ordered and excluded those without testing. Files were available for 5540/5774 (96%) eligible patients and 1632 (30%) were tested for HIV, median age 1.3 years (IQR 9 months to 4 years), 58% <18 months old and 61% male.Primary and secondary outcome measuresThe primary outcome measure was documentation of pretest and post-test counselling, or deferral of counselling, for children tested for HIV in the ED. Secondary measures included the overall rate of HIV testing, rate of counselling documented in the inpatient record when deferred in the ED, rate of counselling documented when testing was initiated by the inpatient service, rate of counselling documented by test result (positive vs negative) and the rate of referral to follow-up HIV care among patients testing positive.ResultsOf 418 patients tested in the ED, counselling, or deferral of counselling, was documented for 70 (17%). When deferred to the ward, subsequent counselling was documented for 15/42 (36%). Counselling was documented in 33% of patients testing positive versus 1.1% patients testing negative (OR 43 (95% CI 23 to 83). Of 199 patients who tested positive and survived to hospital discharge, 76 (38%) were referred for follow-up at the HIV clinic on discharge.ConclusionsPhysicians documented the provision, or deferral, of counselling for <20% of children tested for HIV in the ED. Counselling was much more likely to be documented when the test result was positive. Less than 40% of those testing positive were referred for follow-up care.

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“…HAART is also associated with a signifi cant decrease in the prevalence of oral candidiasis and oral hairy leukoplakia coupled with an improved CD 4 count [30][31][32] . Seemingly in contradicti on with these fi ndings, an increased prevalence of oral warts has been noted by some investi gators despite a marked improvement in CD 4 count.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Oral Health Status as an Indicator of Disease Progression in HIV Positive Children

Damle¹,

Jetpurwala²,

Saini³

et al. 2010

Pesq Bras Odontoped Clin Integr

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RESUMO ABSTRACT DESCRITORESHIV; Contagem de linfócito CD4; Síndrome de Imunodefi ciência Adquirida; Saúde bucal. KEYWORDSHIV; CD4 Lymphocyte count; Acquired Immunodefi ciency Syndrome; Oral health. ISSN -1519-0501 DOI: 10.4034/1519.0501.2010 Objecti ve: To evaluate the oral health status i.e., gingival conditi on, dental caries, oral mucosal lesions progression in a group of HIV positi ve children in relati on to CD4 count. Method: A total of 234 HIV positi ve children in the age group of 2-15 years were included in the present study. Dental caries status was evaluated as per the criteria devised by WHO. Gingival conditi on index was used to assess and criteria given by Muhlemann was used for Papillary Bleeding scores. Plaque was assessed using the Sillness and Loe Index. The children were under acti ve anti retroviral therapy the CD4 count of each pati ent was available from the hospital records. Results: Maximum dmft /defs, score was observed in individuals with CD4 count 200 -500. Whereas highest mean DMFT/DMFS score was seen in children with CD4 count less than 200. The mean plaque, gingival and papillary bleeding score were highest in individuals with CD4 count less than 200 but the diff erence was stati sti cally insignifi cant. Pseudomembranous candidiasis was the most observed oral lesion. Tongue was the most common site of occurrence of oral lesions in all groups. Conclusion:The study confi rms that the oral health status in HIV positi ve children deteriorates with the decline in CD4 count.

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Usefulness of Highly Active Antiretroviral Therapy on Health-Related Quality of Life of Adult Recipients in Tanzania

Cited by 16 publications

References 19 publications

Improvements in health-related quality of life among methadone maintenance clients in Dar es Salaam, Tanzania

Improvements in health-related quality of life among methadone maintenance clients in Dar es Salaam, Tanzania

HIV counselling and testing practices for children seen in an urban emergency department of a tertiary referral hospital in Dar es Salaam, Tanzania: a retrospective cross-sectional study

Evaluation of Oral Health Status as an Indicator of Disease Progression in HIV Positive Children

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