Usefulness of Immature Granulocytes as A Prognostic Factor in ST-Elevation Myocardial Infarction

Korkut, Mustafa; Bedel, Cihan; Sivil, Ramazan; Arslan, Mücahit Alp; Selvi, Fatih; Kuş, Görkem; Zortuk, Ökkeş

doi:10.21470/1678-9741-2021-0088

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…In several studies, IG is an important biomarker in predicting short-term mortality in patient groups. 6,7 However, as far as we know, there is no study todate in the literature on IG in long-term mortality. We think that our study is the first study on this aspect.…”

Section: Discussionmentioning

confidence: 99%

“…25 In addition, Korkut et al found the mortality rates in STelevation myocardial infarction to be significantly higher in the high IG group compared to the low IG group. 7 Moreover, Korkut et al found that high IG levels were significantly associated with 30-day mortality in AIS. 5 Our study showed a statistically significant correlation between high IG value and short-term mortality in cases with AIS.…”

Section: Discussionmentioning

confidence: 99%

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Immature granulocyte and other markers in prediction of the short-term and long-term prognosis of patients with acute ischemic stroke

KOCATÜRK,

GÜLTEN

2023

NeuroAsia

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Background & Objectives: To evaluate immature granulocytes, a new inflammatory biomarker, and other markers in short- and long-term prognosis in patients with acute ischemic stroke (AIS). Methods: Laboratory information system data from a tertiary hospital in Turkiye were used in this retrospective study. Of the 327 patients with the diagnosis of AIS, 275 recovered, and 52 died. It was determined that 31 of these 275 patients, who were followed up retrospectively, died within 12 months after discharge. Routinely measured immature granulocyte (IG), other hemogram parameters in the Sysmex XN 1000 (XN-1000-Hematology-Analyzer-Sysmex Corporation, Japan), and demographic data were statistically compared in both groups. We tried to estimate the short- and long-term mortality from the blood samples of these patients at their first admission to the hospital. Results: Of the patients included in the study, 150 (45.9%) were female, and 177 (54.1%) were male. National Institutes Of Health Stroke Scale (NIHSS) (AUC=960), length of stay (AUC=791), red blood cell distribution width – standard deviation (RDW-CV) (AUC=728), and IG (AUC=712) were the most effective parameters in predicting short-term mortality, while age (AUC=764) in predicting long-term mortality was the most effective parameters. Conclusion: IG, together with NIHSS and length of stay, shows moderate and high predictive properties in prognosticating short-term mortality but is ineffective in prognosticating long-term mortality. Age was found to be the most predictive marker for long-term mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Immature granulocyte and other markers in prediction of the short-term and long-term prognosis of patients with acute ischemic stroke

KOCATÜRK,

GÜLTEN

2023

NeuroAsia

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“…The European Research Journal Volume 9 Issue 2 March 2023 tion [21]. In addition, troponin, CRP, and NLR were used both in clinical scoring and as prognostic indicators [22]. NLR is one of the parameters that have been published in many articles in recent years to predict shortand long-term mortality in patients with STEMI and NSTEMI [23][24][25].…”

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confidence: 99%

Immature granulocyte in prediction of the short-term and long-term mortality of patients with acute myocardial infarction

GÜLTEN

ÇALIŞGAN

Akyel

et al. 2023

The European Research Journal

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Objectives: Despite great advances in the treatment of acute myocardial infarction (AMI), it is still the most common cause of death in the world. Therefore, predicting mortality in advance is clinically very important. In this study, we aimed to investigate the role of immature granulocyte (IG) and other hematological markers in predicting short- and long-term mortality in patients with AMI. Methods: Laboratory information system (LIS) data of a tertiary hospital were used in this study. Of the 298 patients who were admitted to the coronary intensive care unit with the diagnosis of myocardial infarction, 258 recovered after treatment and were discharged. 40 of them died. It was determined that 36 of these 258 patients, who were followed up retrospectively, died within 15 months after discharge. Results: The mean age of 298 people who participated in this retrospective study was 73.26 ± 8.6 years, and 53.3% were male. Moderate and high predictive property in receiver operating characteristic (ROC) analysis for short-term mortality, white blood cell (WBC) area under curve (AUC) = 0.802), neutrophil count (AUC = 0.817), IG count (AUC = 0.841), neutrophil/lymphocyte ratio (NLR) (AUC = 0.701), and C-reactive protein (CRP) (AUC = 0.758) tests detected. For long-term mortality, a moderate predictive feature was observed in the age (AUC = 0.712) parameter. Conclusions: IG is a marker that does not require extra cost, provides rapid results and has high predictive value in predicting death in the short term in patients with acute myocardial infarction. It is ineffective in predicting long-term mortality.

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Immature granulocyte and other markers in prediction of mortality in spontaneous intracerebral hemorrhage

Kocaturk

GÜLTEN

2023

Journal of Health Sciences and Medicine

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Aim: This study aims to evaluate immature granulocyte count (IG#) and percentage (IG%) in the prediction of mortality in spontaneous intracerebral hemorrhage (SICH). Material and Method: Demographic characteristics and laboratory test results of patients diagnosed with SICH and admitted to the neurology clinic in a tertiary hospital between January 1, 2020, and January 1, 2022, were recorded. One hundred ten patients were included in the study. While 80 of these patients constituted the group that recovered after treatment, 30 of them formed the group that died despite treatment. IG and other laboratory and clinic parameters were statistically compared in both groups. Results: Of 110 patients, 45 (42.7%) were female, and 65 (57.3%) were male. IG counts were higher in the non-survival group than in the survival group (p=0.001). When the patients were divided according to low IG% (=0.6), 30 patients were in the high IG# group, and 80 patients were in the low IG% group. White blood cell (WBC), neutrophil count (NEUT#), monocyte count (MONO#), IG#, neutrophil-lymphocyte ratio (NLR), and hemorrhage volume (HV) values were statistically significantly higher in the high IG% group than in the low IG% group; Glasgow coma score (GCS) and percentage of lymphocytes (LYMPH%) values were significantly lower too. In addition, the mortality rate in the high IG# group was significantly higher than the mortality rate in the low IG% group (53.23% vs. 17.5%). Conclusion: IG is a new, easily accessible, inexpensive, and promising marker for predicting in-hospital mortality in patients with SICH.

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Usefulness of Immature Granulocytes as A Prognostic Factor in ST-Elevation Myocardial Infarction

Cited by 3 publications

References 18 publications

Immature granulocyte and other markers in prediction of the short-term and long-term prognosis of patients with acute ischemic stroke

Immature granulocyte and other markers in prediction of the short-term and long-term prognosis of patients with acute ischemic stroke

Immature granulocyte in prediction of the short-term and long-term mortality of patients with acute myocardial infarction

Immature granulocyte and other markers in prediction of mortality in spontaneous intracerebral hemorrhage

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