Usefulness of Immunohistochemial Staining With Antitrepenomal Antibodies in the Diagnosis of Syphilis

Gastric Syphilis Presenting as a Nodal Inflammatory Pseudotumor Mimicking a Neoplasm: Don’t Forget the Treponema! Case Report and Scoping Review of the Literature of the Last 65 Years

“…As a result, clinical, radiological, and endoscopic findings are non-specific and frequently mimic the presentation of gastric adenocarcinoma or lymphoma, making diagnosis difficult, and immune staining is required for this diagnosis. Furthermore, in the reported case, we would like to emphasize the importance of being suspicious of GS when a gastric mass reveals the presence of an IPT on histology, as previously reported for nodal IPT caused by luetic infection [61].…”

Usefulness of immunohistochemical staining in diagnosing a challenging case of oral primary syphilis

“…Also of note, the histopathological examination, suggestive of syphilis, was followed by immunohistochemical antitrepenomal staining, which effectively showed the presence of spirochetes and provided a conclusive diagnosis of primary syphilis [7,8]. As a reminder, the histological structure of the oral mucosa lacks plasma cells [9,10].…”

“…Finally, it is known that syphilis has not been eradicated in the human race and it may have only subsided for a while [4,7,8]. It is important for clinicians dealing with cutaneous and/or oral mucosal lesions to consider the diagnosis of syphilis in challenging clinical cases.…”