Usefulness of immunohistochemistry in delineating renal spindle cell tumours. A retrospective study of 31 cases

Wang, J; Weiss, Lawrence M.; Hu, Bing; Zuppan, Craig W.; Felix, Dominik; Rausei-Mills, Veronica; Chase, Donald R.

doi:10.1111/j.1365-2559.2004.01868.x

Cited by 17 publications

(12 citation statements)

References 35 publications

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“…Furthermore, RCC with admixed smooth muscle-predominant AML may cause diagnostic problems because it may be misdiagnosed as sarcomatoid RCC. 15 These issues have not been addressed previously. We report a series of 16 such cases to highlight the potential pitfall in staging and diagnosis associated with intratumoral fat and concomitant AML.…”

Section: Introductionmentioning

confidence: 91%

Renal Cell Carcinomas With Intratumoral Fat and Concomitant Angiomyolipoma

Aron

Aydın

Sercia

et al. 2010

American Journal of Clinical Pathology

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Intratumoral fat and angiomyolipomas (AMLs) occurring within renal cell carcinomas (RCCs) have rarely been reported but may be mistaken for tumor invasion into perinephric or renal sinus fat or misdiagnosed as tumor exhibiting sarcomatoid differentiation. We report 16 such cases. In 14 RCC cases, there was intratumoral fat, 9 of which had fat located peripherally near the capsule (n = 6), renal sinus (n = 1), or both (n = 2). Inflammatory infiltrates and osseous metaplasia were identified in the intratumoral fat in 7 and 8 cases, respectively. Two cases had intratumoral AML foci located at the periphery of RCC. Intratumoral fat or AML at the periphery of RCC simulated the invasion into the fat, while the smooth muscle component of AML resembled spindle cell, or sarcomatoid, differentiation. Our study highlights the potential pitfalls in staging and diagnosis when intratumoral fat or AML is found within RCC.

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Section: Introductionmentioning

confidence: 91%

Renal Cell Carcinomas With Intratumoral Fat and Concomitant Angiomyolipoma

Aron

Aydın

Sercia

et al. 2010

American Journal of Clinical Pathology

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“…Immunhistochemisch zeigen alle SFTs eine Expression von CD34 und Vimentin, zirka 70 % exprimieren CD99 und bcl-2, während Desmin, Aktin, S-100 und Zytokeratin nicht exprimiert werden [3]. Die Differenzialdiagnosen umfassen das sarkomatoid differenzierte NZK, das Hämangioperizytom, den inflammatorischen myofibroblastischen Tumor, das maligne fibröse Histiozytom, das Fibrosarkom, und neurogene und glattmuskuläre Tumoren, welche sich durch Immunhistochemie abgrenzen lassen [4]. Im Unterschied zum SFT zeigen sarkomatoid differenzierte NZK eine epitheliale Differenzierung mit einer Expression von Zytokeratin, aber sie sind CD34 negativ.…”

Section: Histologie Und Immunhistochemieunclassified

“…Inflammatorische myofibroblastische Tumoren exprimieren glattmuskuläres Aktin und Desmin und kein CD34. Fibrosarkome und maligne fibröse Histiozytome zeigen keine Expression von CD34, neurogene Tumoren exprimieren S-100 und glattmuskuläre Tumoren zeigen eine positive Reaktion auf glattmuskuläres Aktin [4]. SFTs werden wie NZK zunächst chirurgisch therapiert [8].…”

Section: Histologie Und Immunhistochemieunclassified

“…Mit immunhistochemischen Färbungen müssen SFTs von anderen seltenen Nierentumoren abgegrenzt werden. Dazu zählen das sarkomatoid differenzierte Nierenzellkarzinom (NZK), das Hämangioperizytom und das maligne fibröse Histiozytom [4]. Wir berichten hier über einen primär metastasierten renalen SFT, präsentieren eine kumulative Literaturanalyse und stellen die immunhistochemische Differenzialdiagnostik dieser Entität dar.…”

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Der maligne solitäre fibröse Tumor der Niere: Fallbericht und kumulative Literaturanalyse

2012

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We report the case of a primary metastatic renal solitary fibrous tumour (SFT) and present a cumulative analysis of the literature. A 68-year-old woman presenting with a history of flank pain was diagnosed with a 7 cm renal mass. Further staging showed liver, lung and bone metastases. The patient underwent radical nephrectomy. Microscopically, the tumour consisted of pleomorphic, high-grade spindle cells with high mitotic activity, tumour necrosis and dense collagenous bands. Immunohistochemistry showed the strong expression of CD34 and vimentin, a weak expression of bcl-2 and CD99, and no expression of smooth muscle actin, desmin, S-100, pan-cytokeratin, and epithelial membrane antigen. These findings are consistent with an SFT. For the cumulative analysis, a total of 46 renal SFTs from 35 reports were analysed. Median age at the time of surgery was 52 years and 63% of the patients were female. Sixty-two percent of the tumours were symptomatic, most commonly with flank / back pain (24%). Median tumor size was 6.4 cm. Histologically, 91% of the SFTs were benign and 9% were malignant. One patient died of the disease, while 90% are alive without evidence of disease.

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“…Fibrosarkomda CD34, bcl-2 negatiftir. 19,20 Sinoviyal sarkomda EMA ve keratinler, renal anjiyosarkomda da CD31, CD34 ve FVIII pozitiftir. 7 Yakın tarihli bir çalışmada, klasik HPC'nin (selüler SFT) klasik SFT'den (fibröz SFT) daha yük-sek metastaz oranına sahip olduğu gösterilmiştir (%25'e karşılık %5).…”

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Renal Hemangiopericytoma: A Case Report and Current Approach to Hemangioperiocytoma-Solitary Fibrous Tumor

Eken¹,

Tanrıverdi²,

Ozagari³

et al. 2012

Turkiye Klinikleri J Med Sci

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Usefulness of immunohistochemistry in delineating renal spindle cell tumours. A retrospective study of 31 cases

Abstract: Our data indicate that although morphology is most important in formulating the initial differential diagnosis, the addition of immunohistochemistry is vital in arriving at the correct classification of RSCTs.

Cited by 17 publications

References 35 publications

Renal Cell Carcinomas With Intratumoral Fat and Concomitant Angiomyolipoma

Renal Cell Carcinomas With Intratumoral Fat and Concomitant Angiomyolipoma

Der maligne solitäre fibröse Tumor der Niere: Fallbericht und kumulative Literaturanalyse

Renal Hemangiopericytoma: A Case Report and Current Approach to Hemangioperiocytoma-Solitary Fibrous Tumor

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