Usefulness of implementing the <scp>OHIP</scp>‐14 questionnaire to assess the impact of xerostomia and hyposalivation on quality of life in patients with primary Sjögren's syndrome

Valle, Julia Serrano; López‐Pintor, Rosa María; Fernández‐Castro, Mónica; Ramı́rez, Lucı́a; Sanz, Mariano; López, Javier Collado; Blázquez, María Ángeles; González, Jorge Juan; Hernández, Gonzalo

doi:10.1111/jop.13348

Cited by 14 publications

(8 citation statements)

References 36 publications

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“…A weak positive correlation was seen between DMSS for all patients and OHIP-14. This is in accordance with other studies showing a positive correlation between dry mouth and OHRQoL using OHIP-14 [45][46][47].…”

Section: Correlations With Quality Of Life Measurementssupporting

confidence: 93%

Development and Proposal of a Novel Scoring System to Classify Dry Mouth Severity

Frigaard,

Hynne,

Jensen

2023

Applied Sciences

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Dry mouth is a common complaint with unmet treatment needs, reflected by the fact that more than 500 trials are registered on ClinicalTrials.gov. Comparisons across studies, however, are difficult as inclusion criteria vary widely. Additionally, the terms xerostomia and hyposalivation are often not separated. Thus, the aim of the present work was to develop a dry mouth severity score (DMSS) that incorporates published questionnaires and measures both xerostomia and hyposalivation and proposes a grading system that can be used as a common basis for inclusion into clinical trials. The DMSS was developed through the use of data from patients in the Dry Mouth Clinic, University of Oslo, Norway. Five groups of patients (n = 131) and controls (n = 59) were included: primary Sjögren’s syndrome, non-Sjögren’s syndrome, radiated head and neck cancer, psychiatry, and controls. The proposed DMSS includes five parameters with corresponding cut-off values given 1 point (p) each: the General Xerostomia Question ≥ 2, Summated Xerostomia Inventory ≥ 11, Clinical Oral Dryness Score ≥ 6, and secretion of unstimulated and chewing-stimulated whole saliva with cut-off values at ≤0.1 mL/min and ≤0.7 mL/min, respectively. The proposed score range for DMSS is 0–3, where score 0 corresponds to 0p, score 1 to 1–2p, score 2 to 3p, and score 3 to 4–5p. In the patient group, 65% had a high DMSS of 2 or 3, while 78% of the controls scored 0. The sensitivity and specificity were high (0.93 and 0.78, respectively), and the internal reliability was satisfactory (Cronbach’s alpha 0.80). The proposed DMSS represents a novel method to uniformly classify dry mouth patients for applicable comparison between clinical trials.

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Section: Correlations With Quality Of Life Measurementssupporting

confidence: 93%

Development and Proposal of a Novel Scoring System to Classify Dry Mouth Severity

Frigaard,

Hynne,

Jensen

2023

Applied Sciences

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“…The correlations between OHIP-14 and salivary ows were weak and negative, and only signi cant for UWS ow. In the study by Serrano et al 2022 [32], in patients with Sjögren's syndrome they also observed a signi cant correlation with UWS ow and no signi cant correlation with SWS ow. For this reason, we believe that xerostomia and UWS have a greater impact on OHRQoL.…”

Section: Discussionmentioning

confidence: 87%

“…However, Stewart et al 2008 [31], reported a negative moderate correlation between OHIP-14 and UWS ow rate. And Serrano et al 2022 [32], found negative correlations between OHIP-14 and UWS and SWS ow rates in patients with Sjögren's syndrome, only signi cant for UWS ow rate. As mentioned above, the results of the present study showed how OHIP-14 was moderately and signi cantly positively correlated with XI in patients with drug-induced xerostomia.…”

Section: Discussionmentioning

confidence: 97%

Usefulness of the Xerostomia Inventory and Oral Health Impact Profile-14 questionnaires to assess patient-reported outcomes associated with xerostomia in polymedicated patients

Ramı́rez

Sánchez

González‐Serrano

et al. 2023

Preprint

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Objective: The aim of this study was to investigate the association and correlation between patient-reported outcomes associated with xerostomia and salivary flow in polymedicated patients. Subjects and Methods: A cross-sectional study was conducted. Unstimulated (UWS) and stimulated (SWS) salivary flows were collected. Xerostomia was assessed by a question and the use of Xerostomia Inventory (XI). Oral Health-related quality of life was assessed using the Oral Health Impact Profile-14 (OHIP-14). Results: 218 patients were included. 51.8% suffered from xerostomia and 38.1% and 27.5% suffered from UWS and SWS hyposalivation, respectively. Patients with xerostomia, UWS and SWS hyposalivation scored significantly higher on the XI questionnaire than patients without these disorders. However, only patients with xerostomia and UWS hyposalivation were observed to score significantly higher on the OHIP-14 than patients without these alterations. A significant positive correlation was observed between XI and OHIP-14. Significant negative correlations were observed between XI and UWS, and XI and SWS. OHIP-14 was negatively correlated with both salivary flows, but this correlation was only significant between OHIP-14 and UWS flow. Conclusions: Questionnaire XI scores are higher in patients with xerostomia and reduced UWS and SWS flows. However, OHIP-14 is increased in patients with xerostomia and reduced UWS flow. Clinical Relevance: The XI reflects changes in xerostomia and salivary flow so it could be a good questionnaire to assess drug-associated xerostomia in future research studies. However, the OHIP-14 reflects changes in xerostomia level and UWS flow but is not as reliable for assessing changes in SWS flow. Clinical Relevance: The XI reflects changes in xerostomia and salivary flow so it could be a good questionnaire to assess drug-associated xerostomia in future research studies. However, the OHIP-14 reflects changes in xerostomia level and UWS flow but is not as reliable for assessing changes in SWS flow. Trial Registration: None

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“…The quality of life in pSS was also investigated in a group of 61 patients assessed with a questionnaire called OHIP-14 (Oral Health Impact Profile-14), which was developed by dentists in Spain. The responses to this questionnaire showed a positive correlation with both clinical manifestations, such as xerostomia, and a decrease in quality of life [27].…”

mentioning

confidence: 87%

The Translation, Validation and Cultural Adaptation of Questionnaires Assessing the Quality of Life and Fatigue among Patients with Sjogren’s Syndrome for the Romanian Context

Mardale,

Opriș-Belinski,

Bojincă

et al. 2023

Clinics and Practice

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About 70% of patients with Sjogren’s syndrome suffer from fatigue, and for a large proportion of patients, it is one of the most noticeable manifestations leading to disability. To date, no study has been conducted in Romania to determine the quality of life of patients and the impact of fatigue in patients with Sjogren’s syndrome. The present work proposes the translation, cultural adaptation, and validation of two questionnaires for the Romanian context, namely the ‘Profile of Fatigue and Discomfort–Sicca Symptoms Inventory’ (PROFAD-SSI-SF) and ‘Primary Sjogren’s Syndrome—Quality of Life’ (PSS-QoL), whose purpose is to assess quality of life and fatigue in patients with Sjogren’s syndrome. These two questionnaires were administered to 52 patients with Sjogren’s syndrome diagnosed according to the 2016 ACR-EULAR criteria. Subsequently, the conceptual, semantic, and operational analyses of the data were performed with the aim of cultural adaptation. The data obtained were statistically analyzed using indices of measurement accuracy such as internal consistency. Based on statistical analyses, this pilot study shows that the Romanian versions of the PROFAD-SSI and PSS-QoL questionnaires are as reliable as their English counterparts.

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Usefulness of implementing the OHIP‐14 questionnaire to assess the impact of xerostomia and hyposalivation on quality of life in patients with primary Sjögren's syndrome

Cited by 14 publications

References 36 publications

Development and Proposal of a Novel Scoring System to Classify Dry Mouth Severity

Development and Proposal of a Novel Scoring System to Classify Dry Mouth Severity

Usefulness of the Xerostomia Inventory and Oral Health Impact Profile-14 questionnaires to assess patient-reported outcomes associated with xerostomia in polymedicated patients

The Translation, Validation and Cultural Adaptation of Questionnaires Assessing the Quality of Life and Fatigue among Patients with Sjogren’s Syndrome for the Romanian Context

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