Usefulness of Infrared Spectroscopy in Diagnosis of Acute Pancreatitis

Petrov, Maxim S.; Gordetzov, Alexander S.; Emel'Yanov, N. V.

doi:10.1111/j.1445-2197.2007.04057.x

Cited by 8 publications

(6 citation statements)

References 34 publications

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“…In the diagnostic criteria of acute pancreatitis established by the Japanese Ministry of Health, Labour, and Welfare 2008 [1], a diagnosis of acute pancreatitis is made if the patient presents with at least two of the following three manifestations: acute attack of abdominal pain and tenderness in the upper abdomen, elevated levels of pancreatic leaking enzymes and findings of the pancreas detected by US, CT or MRI. Because individual cut‐off levels differ depending upon reports (Table 1) [], at present there is neither sufficient evidence nor consensus to support the setting of cut‐off levels.…”

Section: Introductionmentioning

confidence: 99%

New diagnostic criteria of acute pancreatitis

Kiriyama

Gabata

Takada

et al. 2009

J Hepato Biliary Pancreat

101

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Practical guidelines for the diagnosis of acute pancreatitis are presented so that a rapid and adequate diagnosis can be made. When acute pancreatitis is suspected in patients with acute onset of abdominal pain and tenderness mainly in the upper abdomen, the diagnosis of acute pancreatitis is made on the basis of elevated levels of pancreatic enzymes in the blood and/or urine. Furthermore, other acute abdominal diseases are ruled out if local findings associated with pancreatitis are confirmed by diagnostic imaging. According to the diagnostic criteria established in Japan, patients who present with two of the following three manifestations are diagnosed as having acute pancreatitis: characteristic upper abdominal pain, elevated levels of pancreatic enzymes, and findings of ultrasonography (US), CT or MRI suggesting acute pancreatitis. Detection of elevated levels of blood pancreatic enzymes is crucial in the diagnosis of acute pancreatitis. Measurement of blood lipase is recommended, because it is reported to be superior to all other pancreatic enzymes in terms of sensitivity and specificity. For measurements of the blood amylase level widely used in Japan, it should be cautioned that, because of its low specificity, abnormal high values are also often obtained in diseases other than pancreatitis. The cut-off level of blood pancreatic enzymes for the diagnosis of acute pancreatitis is not able to be set because of lack of sufficient evidence and consensus to date. CT study is the most appropriate procedure to confirm image findings of acute pancreatitis. Elucidation of the etiology of acute pancreatitis should be continued after a diagnosis of acute pancreatitis. In the process of the etiologic elucidation of acute pancreatitis, judgment whether it is gallstone-induced or not is most urgent and crucial for deciding treatment policy including the assessment of whether endoscopic papillary treatment should be conducted or not. The diagnosis of gallstone-induced acute pancreatitis can be made by combining detection of elevated levels of bilirubin, transamylase (ALT, AST) and ALP detected by hematological examination and the visualization of gallstones by US.

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Section: Introductionmentioning

confidence: 99%

New diagnostic criteria of acute pancreatitis

Kiriyama

Gabata

Takada

et al. 2009

J Hepato Biliary Pancreat

101

View full text Add to dashboard Cite

show abstract

“…800 and 1 1,000 nm, respectively, limits spectroscopic studies in these regions [30] . Moreover, our previous study showed that IR spectroscopy in this range successfully distinguished AP from acute abdominal disorders of extrapancreatic origin and from control specimens [31] . Before any further analysis, triplicate spectra from each patient were averaged and the median value for each wavelength was used, giving a total of 846 data points per spectrum.…”

Section: Infrared Spectroscopymentioning

confidence: 99%

Cancer Risk among the Relatives of Patients with Pancreatic Ductal Adenocarcinoma

2007

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“…The idea that a certain physico-chemical technique may identify changes in blood indicative of its oxidative status is not novel. For example, several years ago we pioneered the use of infrared spectroscopy (which measures the wavelengths of infrared light absorbed by a biological fluid) in patients with acute pancreatitis [23,24]. The authors chose another perspective technique, cyclic voltammetry, which is based on the analysis of the intensity of a current crossing a biological fluid over a wide range of voltages, and demonstrated that the current maxima of the first peak of a cyclic voltagram correlated with the severity of pancreatitis as well as with the concentrations of some antioxidants.…”

Section: In-vivo Studiesmentioning

confidence: 99%

Therapeutic implications of oxidative stress in acute and chronic pancreatitis

Petrov

2010

Current Opinion in Clinical Nutrition and Metabolic Care

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A significant advance has been made in the arena of research in chronic, but not acute, pancreatitis. There is now solid evidence to justify the use of oral antioxidants in the treatment of patients with chronic pancreatitis. The progress in clinical research on antioxidants in acute pancreatitis is hampered by several factors, including suboptimal classification of acute pancreatitis and route of administration used in previous studies.

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Usefulness of Infrared Spectroscopy in Diagnosis of Acute Pancreatitis

Abstract: The successful classification of infrared spectra in patients with acute pancreatitis implies that the pathophysiology of disease alters the composition of the specimen in a characteristic fashion--in this case the serum make-up reflects the presence of acute pancreatitis.

Cited by 8 publications

References 34 publications

New diagnostic criteria of acute pancreatitis

New diagnostic criteria of acute pancreatitis

Cancer Risk among the Relatives of Patients with Pancreatic Ductal Adenocarcinoma

Therapeutic implications of oxidative stress in acute and chronic pancreatitis

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