The sustained intra-abdominal hypertension, leading to critical tissue hypoperfusion and permanent functional organ impairment, constitutes the life-threatening disorder of abdominal compartment syndrome (ACS). In recent years, the increased awareness of the presence, clinical importance and devastating impact of ACS has led to dramatic improvements in the diagnosis, definition and management of this lethal disorder. Because of the high incidence of ACS in high-risk patients, regular assessment of intra-abdominal pressure should be performed and timely, evidence-based therapeutic interventions should be employed not only to minimize the risk of developing intra-abdominal hypertension but also to aggressively treat the fully developed ACS. Such an approach will improve patient safety, optimize survival, and decrease morbidity. Among evidence-based measures for the management of ACS surgical decompression remains the method of choice succeeding fast and definitive treatment of the fully developed ACS.