Usefulness of Light Microscopy in Lymph Node Fine Needle Aspiration Biopsy

Egea, Anastasio Serrano; González, Miguel Ángel Martínez; Barrios, Andrés Pérez; Masgrau, Nuria Alberti; Agustín, Pedro de

doi:10.1159/000326735

Cited by 18 publications

(8 citation statements)

References 11 publications

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“…It was similar to the study done by others. [3][4][5][6][7] The most common cytological diagnosis was reactive lymphadenitis, similar to the study done by hirachand et al 4 and Egas et al 8 Tubercular lymphadenitis was the most common diagnosis in the study done by Ruchl et al 3 , Mandakini et al 5 and Haque et al 6 The most common age group was 0-10 years in our study. It was similar to the study done by ruche et al 3 .…”

Section: Discussionsupporting

confidence: 85%

Patterns of lymphadenopathy on fine needle aspiration cytology in eastern Nepal

Mainali¹,

Suwal²

2015

J Pathol Nep

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BACKGROUND:Lymphadenopathy is a commonly encountered clinical problem. Fine needle aspiration cytology offers the alternative of an immediate, preliminary, although not always specific diagnosis with little trauma and cost, thus providing ample information for further management and reduce the amount of open biopsy. MATERIAL AND METHODS:FNAC was performed using 21 gauge needle attached with 10ml disposable needle. Slides were prepared, two were air dried and stained with field stain where as two were fixed in ethanol and was stained with PAP stain. One slide was stained with Ziehl-Neelson stain. Field and PAP stained slide were reviewed and diagnosed by Pathologist. RESULT:Out of the 225 patients, reactive lymphadenitis was the most common diagnosis (54.2%), followed by tubercular lymphadenitis (33.44%). Among the age group percentage of tubercular lymphadenitis was more in 21-30 years of age. Majority of the metastatic carcinoma was in cervical region, comprising mainly squamous cell carcinoma. CONCLUSION:Reactive lymphadenitis was the most common cause of lymphadenopathy especially in case of children. In case of older population, definite pathology for lymph node enlargement was found in most of the cases. Hence FNAC is warranted in lymphadenopathy, as it is simple yet of great diagnostic value.

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Section: Discussionsupporting

confidence: 85%

Patterns of lymphadenopathy on fine needle aspiration cytology in eastern Nepal

Mainali¹,

Suwal²

2015

J Pathol Nep

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“…In this study, benign cytologic diagnosis constitutes a significant proportion of studied cases (58%), of which reactive lymphoid hyperplasia were more than half of benign cases (62%). These figures are compatible with previous studies [10][11][12]. In other previous studies, the ratio between malignant and benign cases was reversed where the percentage of malignant cases was higher than benign cases [13,14].…”

Section: Discussionsupporting

confidence: 93%

Diagnostic Value of Conventional Fine Needle Aspiration Cytology in Cervical Lymphadenopathy

El-Khateeb¹,

Hanna²,

Nassif

2020

The Medical Journal of Cairo University

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“…A review of the literature over the past 10 years shows lymph node FNA to have modest to high sensitivity (66%-100%, mostly Ͼ80%), high specificity (58%-100%, mostly Ͼ90%), and high diagnostic accuracy (50%-100%, mostly Ͼ85%) for non-Hodgkin lymphomas (NHLs). [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] By comparison, FNA evaluation of Hodgkin lymphoma (HL) has lower sensitivity (48%-86%) but a similar high specificity rate (98%-100%). [17][18][19][20] Workup of metastatic neoplasms has shown high sensitivity (91%-98%), high specificity (95%-99%), and high overall accuracy rates (94%-97%).…”

Section: Discussionmentioning

confidence: 99%

“…[17][18][19][20] Workup of metastatic neoplasms has shown high sensitivity (91%-98%), high specificity (95%-99%), and high overall accuracy rates (94%-97%). 4,5,17,21,22 A detailed, exhaustive review of the cytologic features of lymphoma and of metastatic disease is beyond the scope of this review, and we refer the reader to standard texts for details. [23][24][25] This review will address the use of ancillary testing, such as immunohistochemistry on cell block material obtained by FNA and core needle biopsy, flow cytometry, and the selective use of molecular testing.…”

Section: Discussionmentioning

confidence: 99%

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The Advantages and Limitations of the Role of Core Needle and Fine Needle Aspiration Biopsy of Lymph Nodes in the Modern Era

Volmar¹,

Singh²,

Gong

2007

Pathology Case Reviews

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Fine-needle aspiration (FNA) has proven to be a rapid, cost-effective, and accurate means for evaluating a wide variety of conditions in most organ systems, although the FNA diagnosis of lymphoma (especially the primary diagnosis) remains controversial. However, recent changes to the World Health Organization classification of lymphomas place more emphasis on cytology and less emphasis on architecture, thus opening the door to a more expanded use of FNA, particularly in non-Hodgkin lymphomas. A review of the literature over the past 10 years reveals sensitivity in the range of 66%-100% and specificity in the range of 58%-100%. The complementary use of cytomorphology, immunohistochemistry, and flow cytometry has proven more accurate that any single modality alone. Sophisticated techniques once reserved for the research laboratory (ie, FISH and PCR) are now often used in the clinical setting and provide important diagnostic and prognostic information. The evaluation of Hodgkin lymphomas and some large-cell nonHodgkin lymphomas remains problematic and may require tissue core biopsy. We also briefly consider the use of FNA in workup of metastatic tumors in lymph nodes. Rapid and accurate assessment of metastatic disease, particularly carcinomas and melanomas, is readily accomplished by FNA biopsy, with an overall sensitivity, specificity, and accuracy of over 90%. In these cases, cell block material can be obtained to perform various ancillary studies for additional useful prognostic information. CASE REPORTT he patient was a 60-year-old woman with a 2-week history of rapidly enlarging lymphadenopathy. She had a 20-pack/year smoking history but no prior malignancy. Palpable lymph nodes were noted in the supraclavicular region and axilla. Imaging studies of the thorax revealed more widespread lymphadenopathy, involving the mediastinum and para-aortic regions. There was no discrete pulmonary mass. A fine-needle aspiration (FNA) biopsy was performed. Immediate evaluation revealed a mixed population of small and large lymphocytes and tingible body macrophages, suggesting a reactive process (Fig. 1A, B). Given the clinically worrisome presentation, additional passes were obtained for flow cytometry studies. The majority of the analyzed B-cells proved to be polyclonal, consistent with a reactive process (Fig. 1C). However, a small separate population was noted in the region. Back-gating on this population confirmed that a small monoclonal B-cell population was present (Fig. 1D). Furthermore, this monoclonal population showed forward scatter characteristics, indicating a large cell size relative to the reactive population. The findings were consistent with a small monoclonal B-cell population, confirming the clinical suspicion of lymphoma. DISCUSSIONFNA is a rapid, cost-effective, and accurate means for evaluating lymphadenopathy. Often, a lymph node FNA specimen provides sufficient information to decide whether a patient requires simple observation, antimicrobial therapy for an infectious process, radiation or chemotherapy...

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Usefulness of Light Microscopy in Lymph Node Fine Needle Aspiration Biopsy

Cited by 18 publications

References 11 publications

Patterns of lymphadenopathy on fine needle aspiration cytology in eastern Nepal

Patterns of lymphadenopathy on fine needle aspiration cytology in eastern Nepal

Diagnostic Value of Conventional Fine Needle Aspiration Cytology in Cervical Lymphadenopathy

The Advantages and Limitations of the Role of Core Needle and Fine Needle Aspiration Biopsy of Lymph Nodes in the Modern Era

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