Usefulness of linked color imaging in the early detection of superficial esophageal squamous cell carcinomas

Nakamura, Koki; Urabe, Yuji; Oka, Shiro; Nagasaki, Naoko; Yorita, Naoki; Hata, Kosaku; Masuda, Kazuhiko; Kurihara, Mio; Kotachi, Takahiro; Boda, Tomoyuki; Tanaka, Shinji; Chayama, Kazuaki

doi:10.1007/s10388-020-00749-2

Cited by 15 publications

(12 citation statements)

References 28 publications

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“…EACs in LSBE were reported to be less frequently reddish compared to EACs in SSBE [ 30 ], which may have affected these results. Recently, Nakamura et al reported that LCI improved the visibility of esophageal squamous cell carcinoma [ 31 ]. Furthermore, they showed that its usefulness was higher in cases without background coloration.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Linked Color Imaging in the Endoscopic Diagnosis of Barrett’s Esophagus and Esophageal Adenocarcinoma

Tokunaga

Matsumura

Ishikawa

et al. 2020

Gastroenterology Research and Practice

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Background. The present study aimed to evaluate the efficacy of linked color imaging (LCI) in diagnosing Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC). Methods. A total of 112 and 12 consecutive patients with BE and EAC were analyzed. The visibility scores of BE and EAC ranging from 4 (excellent visibility) to 0 (not detectable) were evaluated by three trainees and three experts using white light imaging (WLI), LCI mode, and blue laser imaging bright (BLI-b) mode. In addition, L ∗ a ∗ b ∗ color values and color differences ( Δ E ∗ ) were evaluated using the CIELAB color space system. Results. The visibility score of the BE in LCI mode ( 2.94 ± 1.32 ) was significantly higher than those in WLI ( 2.46 ± 1.48 ) and BLI-b mode ( 2.35 ± 1.46 ) ( p < 0.01 ). The color difference ( Δ E ∗ ) from the adjacent gastric mucosa in LCI mode ( 17.11 ± 8.53 ) was significantly higher than those in other modes ( 12.52 ± 9.37 in WLI and 11.96 ± 6.59 in BLI-b mode, p < 0.01 ). The visibility scores of EAC in LCI mode ( 2.56 ± 1.47 ) and BLI-b mode ( 2.51 ± 1.28 ) were significantly higher than that in WLI ( 1.64 ± 1.46 ) ( p < 0.01 ). The color difference ( Δ E ∗ ) from the adjacent normal Barrett’s mucosa in LCI mode ( 19.96 ± 7.97 ) was significantly higher than that in WLI ( 12.95 ± 11.86 ) ( p = 0.03 ). Conclusion. The present findings suggest that LCI increases the visibility of BE and EAC and contributes to the improvement of the detection of these lesions.

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Section: Discussionmentioning

confidence: 99%

The Efficacy of Linked Color Imaging in the Endoscopic Diagnosis of Barrett’s Esophagus and Esophageal Adenocarcinoma

Tokunaga

Matsumura

Ishikawa

et al. 2020

Gastroenterology Research and Practice

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“…Three expert endoscopists who performed >10,000 esophagogastroduodenoscopies and three non-expert endoscopists who performed < 300 esophagogastroduodenoscopies evaluated the visibility. The endoscopists scored the visibility of the lesions on each image obtained via TXI mode1; TXI mode2; and NBI, compared to that of the WLI, according to the following scale: +1 (improved visibility of lesion), 0 (unchanged visibility of lesion), and −1 (worsened visibility of lesion) [10].…”

Section: The Evaluation Of Endoscopic Imagesmentioning

confidence: 99%

“…The warning signal for SESCCs or SPSCCs is a subtle color or morphological change in the WLI [5], and it has been challenging to detect malignancies at an early stage, before the development of image-enhanced endoscopy (IEE) [4][5][6][7][8][9][10]. Narrow-band imaging (NBI) systems can enhance microvessels well into the mucosal surface, and both SPSCCs and SESCCs present a brownish area under NBI.…”

Section: Introductionmentioning

confidence: 99%

Texture and Color Enhancement Imaging Increases Color Changes and Improves Visibility for Squamous Cell Carcinoma Suspicious Lesions in the Pharynx and Esophagus

et al. 2021

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Texture and color enhancement imaging (TXI) has been developed as an image-enhanced endoscopy technology. TXI mode2 enhances texture and brightness, and TXI mode1 also enhances color. This study aims to assess the color differences in squamous cell carcinoma (SCC) suspicious lesions in the pharynx and esophagus using white light imaging (WLI), TXI mode1, TXI mode2, and narrow-band imaging (NBI). A total of 59 SCC suspicious lesions from 30 patients were analyzed. The color differences (ΔE) between the lesion and the surrounding mucosa were calculated for each modality. The color value was assessed using the Commission Internationale d’Eclairage L*a*b* color space. The visibility of the lesion in each modality was evaluated and compared to that in the WLI by six endoscopists. The mean ΔE values in the WLI, TXI mode1, TXI mode2, and NBI were 11.6; 18.6; 14.3; and 17.2, respectively, and the ΔE values of TXI mode1, TXI mode2, and NBI were significantly higher than those of the WLI (p < 0.001). No lesions had worse visibility, and 62.5% (37/59) had improved visibility, as assessed by more than half of the endoscopists in TXI mode1. TXI mode1 can enhance color changes and improve the visibility of SCC suspicious lesions in the pharynx and esophagus, compared to WLI.

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“…The color difference between the lesion and background mucosa was significantly higher in LCI then in WLE (20.8 ± 7.9 vs. 9.2 ± 6.1, p< 0.05). 78…”

Section: A B D Cmentioning

confidence: 99%

Current Status of Image-Enhanced Endoscopy for Early Identification of Esophageal Neoplasms

Kim

Hong

2021

Clin Endosc

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The early detection of esophageal neoplasms, including esophageal dysplasia and early esophageal cancer, is highly important for the accurate treatment of the disease. However, esophageal dysplasia and early esophageal cancer are usually subtle and can be easily missed. In addition to the early detection, proper pretreatment evaluation of the depth of invasion of esophageal cancer is very important for curative treatment. The progression of non-invasive diagnosis via image-enhanced endoscopy techniques has been shown to aid the early detection and estimate the depth of invasion of early esophageal cancer and, as a result, may provide additional opportunities for curative treatment. Here, we review the advancement of image-enhanced endoscopy-related technologies and their role in the early identification of esophageal neoplasms.

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Usefulness of linked color imaging in the early detection of superficial esophageal squamous cell carcinomas

Cited by 15 publications

References 28 publications

The Efficacy of Linked Color Imaging in the Endoscopic Diagnosis of Barrett’s Esophagus and Esophageal Adenocarcinoma

The Efficacy of Linked Color Imaging in the Endoscopic Diagnosis of Barrett’s Esophagus and Esophageal Adenocarcinoma

Texture and Color Enhancement Imaging Increases Color Changes and Improves Visibility for Squamous Cell Carcinoma Suspicious Lesions in the Pharynx and Esophagus

Current Status of Image-Enhanced Endoscopy for Early Identification of Esophageal Neoplasms

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