Usefulness of Magnetic Resonance Imaging as a Prognostic Variable in Myelodysplastic Syndromes

Ziółko, Ewa; Kwiatkowska-Pamuła, Anna; Adamczyk, Tomasz; Walecki, Jerzy; Muc-Wierzgoń, Małgorzata

doi:10.12659/msm.890978

Cited by 2 publications

(2 citation statements)

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“…The fact that it is not hypointense when compared with the neighboring muscle, the fact that it does not reach the epiphysis and diaphysis, it does not have an accompanying soft tissue lesion and cortical destruction support that it is not pathological [ 14 – 16 ].…”

Section: Discussionmentioning

confidence: 99%

MRI of Residual Red Bone Marrow in the Distal Femur of Healthy Subjects

2015

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SummaryBackroundThe purpose of our study is to examine the correlation of the residual red bone marrow areas of distal femoral metaphysis with the age, gender, weight and hemoglobin (hgb) values; evaluate the results, and comprehend the importance of these residual areas in the light of the results.Material/Methods140 nonsmoking patients between the ages of 26 and 72 (92 women, 48 men) who had knee MR examinations were included in the study. The residual red bone marrow areas in the distal femoral metaphysis in MR images were examined by a radiologist. The areas were separated into grades according to their sizes. The hemoglobin values of the cases were measured. The size of the residual red bone marrow area and the age, gender, weight and hemoglobin values of the cases were compared by using the Tukey and Chi-Square Tests.ResultsAlthough no significant differences were observed between the mean ages, weights and hemoglobin values of the grades, a significant difference was detected between the gender distribution The male group had less residual red bone marrow in the distal femoral metaphysis than the female group (p=0.003).ConclusionsWe observed that the hypointensities due to residual red bone marrow observed in the T1WS of the distal femoral metaphysis are not related with the age, weight and hemoglobin values. No grade 2 and grade 3 patient was detected in male group. We observed that these hypointense areas showed difference according to the gender variable; however, were not affected by the hemoglobin values over certain levels.

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Section: Discussionmentioning

confidence: 99%

MRI of Residual Red Bone Marrow in the Distal Femur of Healthy Subjects

2015

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“…Myelodysplastic syndrome (MDS) is an acquired blood disorder characterized by varying degrees of ineffective hematopoiesis. MDS is a heterogeneous group of hematopoietic diseases and efforts to predict its prognosis are made by WHO classification system, International Prognostic Scoring system, and also recently by magnetic resonance imaging [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

A Case of Myelodysplastic Syndrome with Intestinal Behçet’s Disease-Like Symptoms Treated by Prednisolone and Azacitidine

et al. 2015

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Patient: Female, 68Final Diagnosis: Myelodysplastic Syndrome with Intestinal Behçet’s Disease-Like SymptomsSymptoms: Abdominal pain • fever • oral ulcerMedication: —Clinical Procedure: CT • bone marrow examination • colonoscopySpecialty: HematologyObjective:Rare diseaseBackground:Intestinal Behçet’s disease-like symptoms are rare complications of myelodysplastic syndrome and are often refractory to immunosuppressive therapies. We described a case of myelodysplastic syndrome complicated by Behçet’s disease-like symptoms treated with prednisolone and azacitidine.Case Report:A 68-year-old Japanese woman was admitted to our hospital because of persistent high fever and lower abdominal pain. Oral ulcerations developed after admission, and multiple ulcers were found in her terminal ileum by endoscopic examination. She was diagnosed with myelodysplastic syndrome with trisomy 8 by bone marrow examination. Her symptoms diminished after administration of prednisolone, but relapsed afterwards. She began azacitidine therapy and her symptoms have been controlled for at least 10 months.Conclusions:This case might suggest the possibility of azacitidine as a treatment option for myelodysplastic syndrome complicated by Behçet’s disease-like symptoms.

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Usefulness of Magnetic Resonance Imaging as a Prognostic Variable in Myelodysplastic Syndromes

Cited by 2 publications

References 29 publications

MRI of Residual Red Bone Marrow in the Distal Femur of Healthy Subjects

MRI of Residual Red Bone Marrow in the Distal Femur of Healthy Subjects

A Case of Myelodysplastic Syndrome with Intestinal Behçet’s Disease-Like Symptoms Treated by Prednisolone and Azacitidine

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