Usefulness of mannitol challenge testing for diagnosing asthma in everyday clinical practice

Pedersen, Signe Knag; Ustrup, Amalie S; Baarnes, Camilla Boslev; Ulrik, Charlotte Suppli

doi:10.1080/02770903.2019.1600144

Cited by 8 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PD15 and RDR are expressed as median (IQR) (non-parametrical variables), FEV1 is expressed as mean (SD) (parametrical variable), and the categorical variables are expressed as the number of Taking into account the possible overlap between exercise-induced and nocturnal asthma, we distributed our patients into four distinct groups, according to their clinical symptoms at baseline: Group 1: "Presence of both exercise-induced and nocturnal asthma symptoms" (n = 10); Group 2: "Only nocturnal asthma symptoms" (n = 3); Group 3: "Only exercise-induced asthma symptoms" (n = 6); and Group 4: "Absence of both exerciseinduced and nocturnal asthma symptoms" (n = 4). Despite the fact that the Kruskal-Wallis test did not demonstrate any significant difference in PD 15 between these groups (p = 0.15), children experiencing nocturnal symptoms (Group 1 and 2) tended to have lower PD 15 [Group 1: 470 mg (122-635); Group 2: 345 mg (177-490); Group 3: 635 mg (635-635); Group 4: 635 mg (503-635)], as depicted in Figure 3.…”

Section: Associations Between Pd 15 and Patient Characteristicsmentioning

confidence: 72%

“…The MDP challenge has been demonstrated as a practical tool for BHR evaluation in clinical practice due to the combination of portability, reproducibility and high specificity in asthma diagnosis [13][14][15]. In addition, it has been suggested as a potential monitoring tool for assessing the impact of ICS prophylaxis on airway inflammation and BHR in asthmatic subjects [12,16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mannitol Challenge to Assess Therapy Response in Asthmatic Children: An Interventional Cohort Study

et al. 2023

View full text Add to dashboard Cite

Bronchial provocation tests, such as the mannitol challenge, can be performed to identify and quantify the severity of bronchial hyperresponsiveness in asthmatic patients. Studies of the mannitol challenge as a monitoring tool in asthmatic children are limited. Our primary aim was to compare the bronchial hyperresponsiveness to mannitol in treatment-naive asthmatic children between baseline and three months after receiving the indicated asthma prophylaxis. Twenty-three asthmatic patients aged 4–16 years were analyzed in this prospective cohort study. All subjects underwent the mannitol challenge at baseline and after three months of treatment with budesonide ± formoterol. The difference in the provocative dose of mannitol to induce a 15% drop in FEV1 (PD15) between baseline and follow-up, as well as its association with the presence of exercise-induced or nocturnal asthma symptoms, were evaluated. The PD15 value increased significantly post-treatment (228.5 mg [4.50–458.15]; p = 0.04). Independently of the evaluation time point, the PD15 values were significantly lower in the presence of nocturnal asthma symptoms (490 mg [122–635] vs. 635 mg [635–635]; p = 0.03), whereas there was no association between the PD15 value and the presence of exercise-induced asthma (p = 0.73). These results suggest that bronchial hyperresponsiveness to mannitol may be a potential monitoring tool in the pediatric asthmatic population, reflecting therapy response in children receiving prophylactic treatment.

show abstract

Section: Associations Between Pd 15 and Patient Characteristicsmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Mannitol Challenge to Assess Therapy Response in Asthmatic Children: An Interventional Cohort Study

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The kit provided for the bronchial challenge test includes filled capsules of mannitol in increasing doses and a dry powder inhaler. The challenge is carried out as previously described [ 42 ]. An evaluation of the safety of mannitol as a bronchial challenge test has previously been published [ 43 ].…”

Section: Methodsmentioning

confidence: 99%

Relationship between early life asthma and chronic airway disease in adult life – in search for disease trajectories over the life span- the RELATE study based on the Kongsberg cohort

Savran,

Bønnelykke,

Ulrik

2023

BMC Pulm Med

View full text Add to dashboard Cite

Background Chronic airway disease in adults may have its origin in early life. The purpose of this study is to investigate the long-term prognosis of severe childhood asthma in search for an association between asthma in early life and obstructive lung disease in adulthood. Methods This study is based on the Kongsberg cohort, which includes approximately 5000 children with severe asthma with a 4-month stay at the asthma care facility in Kongsberg, Norway during the years 1950 to 1979. An on average 60-year observational study based on a follow-up examination will be performed including questionnaires, blood samples, and tests of lung function and bronchial responsiveness. Blood samples will be stored in a biobank. In addition, we will conduct further analyses of the cohort based on nationwide register data, including socio-economic parameters and mortality. Discussion Chronic airway disease is associated with substantial burden for both the individual patient and society. Our knowledge of early life origins of chronic airway disease later in life has been increasing in recent decades but is still limited. By exploring early life risk factors for chronic airway disease in adulthood, we may gain insights paving the way for future reduction in the burden of chronic airway diseases.

show abstract

“…The kit provided for the bronchial challenge test includes lled capsules of mannitol in increasing doses and a dry powder inhaler. The challenge is carried out as previously described (41). An evaluation of the safety of mannitol as a bronchial challenge test has previously been published (42).…”

Section: Examination Program At Study Visitmentioning

confidence: 99%

Relationship between early life asthma and chronic airway disease in adult life – in search for disease trajectories over the life span - The RELATE study based on the Kongsberg cohort

Savran

Bønnelykke

Ulrik

2023

Preprint

View full text Add to dashboard Cite

Background: Chronic airway disease in adults may have its origin in early life. The purpose of this study is to investigate the long-term prognosis of severe childhood asthma in search for an association between asthma in early life and obstructive lung disease in adulthood. Methods: This study is based on the Kongsberg cohort, which includes approximately 5000 children with severe asthma with a 4-month stay at the asthma care facility in Kongsberg, Norway during the years 1950 to 1979. An on average 60-year follow-up examination will be performed including questionnaires, blood samples, and tests of lung function and bronchial responsiveness. Blood samples will be stored in a biobank. In addition, we will conduct further analyses of the cohort based on nationwide register data, including socio-economic parameters and mortality. Discussion: Chronic airway disease is associated with substantial burden for both the individual patient and society. Our knowledge of early life origins of chronic airway disease later in life has been increasing in recent decades but is still limited. By exploring early life risk factors for chronic airway disease in adulthood, we may gain insights paving the way for future reduction in the burden of chronic airway diseases.

show abstract

Usefulness of mannitol challenge testing for diagnosing asthma in everyday clinical practice

Cited by 8 publications

References 22 publications

Mannitol Challenge to Assess Therapy Response in Asthmatic Children: An Interventional Cohort Study

Mannitol Challenge to Assess Therapy Response in Asthmatic Children: An Interventional Cohort Study

Relationship between early life asthma and chronic airway disease in adult life – in search for disease trajectories over the life span- the RELATE study based on the Kongsberg cohort

Relationship between early life asthma and chronic airway disease in adult life – in search for disease trajectories over the life span - The RELATE study based on the Kongsberg cohort

Contact Info

Product

Resources

About