Usefulness of Mean Platelet Volume as a Biomarker for Long-Term Outcomes After Percutaneous Coronary Intervention

Gonçalves, Sandro Cadaval; Labinaz, Marino; May, Michel Le; Glover, Chris; Froeschl, Michael; Marquis, Jean-François; O'Brien, Edward R.; Shukla, Dino; Ruchin, Peter; Sookur, Dharmendra; Ha, Andrew C.T.; So, Derek

doi:10.1016/j.amjcard.2010.08.068

Cited by 69 publications

(55 citation statements)

References 29 publications

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“…The mean platelet volume, a platelet activation marker, is a widely available and easily measured hematologic test in a complete blood cell count test [7], and the elevated one has been demonstrated to be associated with diabetes mellitus, hypertension, hypercholesterolemia, and obesity [7]. In addition, it has been found to be a diagnostic and prognostic marker in patients with ACS or those undergoing percutaneous coronary intervention [15][16][17]. However, in a prospective study, no relationship was found between increased baseline mean platelet volume and the clinical outcomes of patients undergoing elective angioplasty, but increases in postoperative serial measurements were associated with higher mortality rate instead [18].…”

Section: Discussionmentioning

confidence: 99%

White blood cell count to mean platelet volume ratio as a novel non-invasive marker predicting long-term outcomes in patients with non-ST elevation acute coronary syndrome

2015

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(p < 0.001). In an adjusted cox regression model, the elevated WMR was independently predicted the incidence of MACE (hazard ratio 2.419, p < 0.001). Conclusions:The elevated baseline WMR independently predicted the MACE incidence in patients with NSTE-ACS during long-term follow-up. (Cardiol J 2015; 22, 4: 437-445) Key words: white blood cell to mean platelet volume ratio, non-ST elevation acute coronary syndrome, major adverse cardiovascular events

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Section: Discussionmentioning

confidence: 99%

White blood cell count to mean platelet volume ratio as a novel non-invasive marker predicting long-term outcomes in patients with non-ST elevation acute coronary syndrome

2015

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“…12 Increased platelet reactivity found in highervolume platelets has been shown to result in clinical symptoms in different scenarios of coronary disease, both in the short and long term. A study by Gonçalves et al 13 in an unselected population of 1,432 patients undergoing PCI demonstrated that MPV > 9 fL measured before the procedure was independently associated with the incidence of death or myocardial infarction at the 1 year follow-up. Another recent study demonstrated that elevated MPV was independently associated with myocardial infarction without ST-segment elevation, low ejection fraction, and culprit lesion severity in patients with acute coronary syndrome without ST-elevation.…”

Section: Discussionmentioning

confidence: 99%

Volume Plaquetário Médio Como Preditor de Desfechos Cardiovasculares Maiores e Fluxo Coronariano Final em Pacientes Submetidos à Intervenção Coronária Percutânea Primária

Bergoli¹,

Castanho²,

Gonçalves³

et al. 2014

Rev. Bras. Cardiol. Invasiva

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background:Platelets play a key role in the pathophysiology of acute myocardial infarction. There is evidence that higher platelet volumes may have increased prothrombotic potential. The aim of this study was to evaluate whether mean platelet volume can predict culprit coronary vessel flow and adverse cardiovascular outcomes in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Methods: Primary endpoint was the composite of adverse cardiovascular events (death, stroke, myocardial infarction, stent thrombosis, class-III or IV angina and heart failure) at 30 days. The secondary endpoint was evaluated by the angiographic TIMI flow grade after the procedure. results: Of the 215 patients included in the primary percutaneous coronary intervention registry, 168 (78.6%) had their mean platelet volume calculated before the procedure and were analyzed in the present study. Mean platelet volume values were stratified in tertiles, and a high value was considered as > 11 femtoliters (fL). Mean platelet volume > 11 fL was an independent predictor of cardiovascular events at 30 days (p = 0.02). It was observed that patients with final TIMI flow grade zero or 1 showed a trend towards higher mean platelet volume compared with those with final TIMI flow 2 or 3 (11.3 ± 0.9 fL vs. 10.5 ± 1.3 fL; p = 0.06). Conclusions: Baseline mean platelet volume is a simple, useful, and easy to measure marker to predict the risk of cardiovascular events at 30 days in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Future studies may answer whether more aggressive antithrombotic therapy results in better angiographic and/or clinical outcomes in patients with larger and more active platelets.

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Section: Introductionmentioning

confidence: 99%

“…Larger size platelets are frequently seen in females and those N 75 years old [6]. The proportion of larger size platelets increases in patients with acute myocardial infarction [7,8] and the MPV is associated with the no-reflow phenomenon in patients with ST elevation myocardial infarction (STEMI) and thereby it may adversely alter the clinical outcome [9].The elevation of the ST segment in electrocardiography is generally associated with a significant injury to the myocardium compared to those with no elevation of the ST segment. Early revascularization of the myocardium is the mainstay of therapeutic strategy for an acute coronary syndrome [10].…”

mentioning

confidence: 99%

Mean platelet volume is a predictor of ST resolution following thrombolysis in acute ST elevation myocardial infarction

Ghaffari

Pourafkari

Javadzadegan

et al. 2015

Thrombosis Research

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Usefulness of Mean Platelet Volume as a Biomarker for Long-Term Outcomes After Percutaneous Coronary Intervention

Cited by 69 publications

References 29 publications

White blood cell count to mean platelet volume ratio as a novel non-invasive marker predicting long-term outcomes in patients with non-ST elevation acute coronary syndrome

White blood cell count to mean platelet volume ratio as a novel non-invasive marker predicting long-term outcomes in patients with non-ST elevation acute coronary syndrome

Volume Plaquetário Médio Como Preditor de Desfechos Cardiovasculares Maiores e Fluxo Coronariano Final em Pacientes Submetidos à Intervenção Coronária Percutânea Primária

Mean platelet volume is a predictor of ST resolution following thrombolysis in acute ST elevation myocardial infarction

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