Usefulness of Measurement of Lens Culinaris Agglutinin-Reactive Fraction of α-Fetoprotein As A Marker of Prognosis and Recurrence of Small Hepatocellular Carcinoma

Hayashi, Kazuhiko; Kumada, Takashi; Nakano, Satoshi; Takeda, Isao; Sugiyama, Keiichi; Kiriyama, Seiki; Sone, Yoshitsugu; Miyata, Akihiro; Shimizu, Hideyuki; Satomura, Shinji

doi:10.1111/j.1572-0241.1999.01378.x

Cited by 90 publications

(41 citation statements)

References 31 publications

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“…Finally, survival is longer in the patients with normal than in those with elevated AFP-L3% values. In summary, AFP-L3% is useful not only for diagnosis, treatment efficacy and recurrence of HCC, but also for assessing biological malignancy and the selection of therapeutic interventions [4,5,7].…”

Section: Afp-l3mentioning

confidence: 99%

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Tumor Markers in Early Diagnosis, Follow-Up and Management of Patients with Hepatocellular Carcinoma

et al. 2002

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Section: Afp-l3mentioning

confidence: 99%

“…The difference is reflected on the binding activity to Lens culinaris agglutinin A. In practice, the percentage of AFP that binds with L. culinaris agglutinin A, referred to as APF-L3, is highly specific for the presence of HCC [1][2][3][4][5][6][7].…”

mentioning

confidence: 99%

Tumor Markers in Early Diagnosis, Follow-Up and Management of Patients with Hepatocellular Carcinoma

et al. 2002

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“…Another reported problem of AFP is low specificity because of a high false-positive rate with benign conditions such as acute and chronic active hepatitis (21)(22)(23)(24). Several authors have demonstrated that Lens culinaris agglutinin-reactive ·-fetoprotein (AFP-L3) can distinguish between HCC and hepatitis by detecting a sugar chain microheterogeneity (25)(26)(27). Our previous studies have demonstrated that glypican-3 (GPC3) is a novel tumor marker of HCC and is especially useful in the early stages because of its high sensitivity (28-31).…”

Section: Discussionmentioning

confidence: 99%

Postoperative serum α-fetoprotein level is a useful predictor of recurrence after hepatectomy for hepatocellular carcinoma

et al. 2010

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Abstract. We evaluated the clinical value of perioperative ·-fetoprotein (AFP) and des-Á-carboxy prothrombin (DCP) levels in predicting recurrence of hepatocellular carcinoma (HCC) after curative resection, with a focus on the time course as surveillance tools. A total of 165 consecutive HCC patients who had undergone curative hepatectomy at our institution from 2005 to 2007 and whose serum AFP and DCP had been measured before and after hepatectomy were included in this study. The minimum postoperative levels within a 4-month period were used for analysis. Among the patients with a positive level of AFP before operation, the number of patients whose AFP level did not change from positive to negative after operation in the group with recurrence exceeded that in the group without recurrence (48/60, 80.0% vs. 4/23, 17.4%), and the difference was significant (P<0.001). Minimum postoperative AFP level was found to be a significant independent risk factor for recurrence by multivariate analysis (P<0.001). There was no statistically significant correlation between AFP level and grade of hepatitis activity (P=0.599). Postoperative AFP level is a useful tool for predicting recurrence after curative hepatectomy. A positive level of AFP after operation might suggest a site of residual viable cancer. The need for effective adjuvant therapy and close follow-up is suggested in patients with a positive postoperative AFP level.

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“…Previous studies have reported that HCC with high AFP-L3 levels demonstrate characteristics of advanced HCC by pathologic [13] and imaging findings [22]. Higher recurrence rates [23] and lower survival rates [12,14] after treatment have also been reported in patients with increased AFP-L3 at diagnosis. We sought to determine whether these benefits of AFP-L3 persist with hs-AFP-L3.…”

Section: Hs-afp-l3 For Evaluating the Prognosis Of Patients With Hccmentioning

confidence: 95%

Highly Sensitive <i>Lens culinaris</i> Agglutinin-Reactive α-Fetoprotein: A New Tool for the Management of Hepatocellular Carcinoma

Toyoda¹,

Kumada²,

Tada³

2011

Oncology

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Objectives: The highly sensitive Lens culinaris agglutinin-reactive α-fetoprotein (hs-AFP-L3), measured using a newly developed method involving microfluidics-based separation technology, was evaluated as a new tool for the management of hepatocellular carcinoma (HCC) in clinical practice. Methods: The sensitivity and specificity of hs-AFP-L3 for the diagnosis of HCC and its ability to predict the outcome of patients with HCC were analyzed based on reported studies. Results: Compared to AFP-L3 measured using conventional methods, the sensitivity of hs-AFP-L3 was markedly higher and the specificity was comparable. In all studies, multivariate analysis found that elevation of hs-AFP-L3 was an independent factor that affected patient survival. Conclusions: The use of hs-AFP-L3 improves the true positive rate of patients with HCC at diagnosis, maintaining the high specificity of AFP-L3 and its indicative value for poor prognosis. The utility of this tumor marker for prediction of the development of HCC in high-risk patients under surveillance needs to be investigated.

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Usefulness of Measurement of Lens Culinaris Agglutinin-Reactive Fraction of α-Fetoprotein As A Marker of Prognosis and Recurrence of Small Hepatocellular Carcinoma

Abstract: Measurement of AFP-L3% after treatment may be useful for understanding prognosis and recurrence of HCC.

Cited by 90 publications

References 31 publications

Tumor Markers in Early Diagnosis, Follow-Up and Management of Patients with Hepatocellular Carcinoma

Tumor Markers in Early Diagnosis, Follow-Up and Management of Patients with Hepatocellular Carcinoma

Postoperative serum α-fetoprotein level is a useful predictor of recurrence after hepatectomy for hepatocellular carcinoma

Highly Sensitive <i>Lens culinaris</i> Agglutinin-Reactive α-Fetoprotein: A New Tool for the Management of Hepatocellular Carcinoma

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