Usefulness of Measuring Serum LH Concentration on Day 1 Before Ovarian Stimulation in Non- Obese Polycystic Cases

Abstract

Background: Polycystic ovarian syndrome is associated with high LH related to infertility. Objectives: We aim at detecting the effect of day 1 LH on the outcome of controlled ovarian stimulationin slim PCOS cases to determine a cut-off value for LH. Study design: We retrospectively analysed the out-come of stimulated cycles in PCOS cases with a body mass index 18-29 kg/m2 visiting the reproductive medicine clinic in El Shatby university hospital ,Egypt. They were divided into two groups: Group A( LH less than or equal to 6IU/dl ) and Group B ( LH more than 6).Recombinent FEH was started day 2 and ovarian responce was monitored by folllicular scanning and serum estradiol (E2). HCG trigger was considered when the leading follicle is at least 18 mm , luteal phase was supported by vaginal micronised progesterone. Prenancy test in blood was done 16 days later. Results: significant difference was found in gonadotrophin dose and in pregnancy rate. Conclusion: Day 1 LH had a negative predictive value better than a positive predictive value for occurrence of pregnancy.