Usefulness of measuring the concentration of thyroglobulin antibodies in serum of dogs for the assessment of thyroid functioning

Abstract

The aim of the study was to estimate the usefulness of measuring the thyroglobulin antibodies (TgAb s ) concentration in dogs' serum in order to assess thyroid functioning. The study was performed on 383 dogs. The animals were divided into two groups: group A (n = 308) consisted of dogs with hypothyroidism and group B (n = 75) consisted of dogs with euthyreosis. TgAb s was determined in both groups. The reaction to the TgAb s in group A was strongly positive in 32% of dogs, weakly positive in 33% of dogs, and negative in 35% of dogs. The TgAb s were observed in 32% of the dogs from group B, in which 8% of the animals had strongly positive reaction (++) and 24% -slightly positive (+). The correlation between the concentration of total and free fraction of the thyroxin and the level of the TgAb s were observed in group A. The tendency to positive reaction to the antibodies (++) in dogs with lower concentrations of total thyroxine and free thyroxine was observed. It was noted that the presence of the TgAb s was common in dogs with hypothyroidism. However, it could be also found in the animals with euthyreosis.

Breed-specific reference intervals for assessing thyroid function in seven dog breeds

“…This agrees with other studies that have reported similar percentages (0-5%) of TgAA in the serum of healthy dogs. 5,14,16,20,23,33,35 The prevalence of TgAA-positive dogs was much higher (28%) in English Setters when compared with the other 6 breeds (0-5%). This finding agrees with a previous report demonstrating that the English Setter breed has the highest prevalence of thyroglobulin antibody (31% of 585 English Setters tested) out of 140,821 serum samples submitted to a commercial diagnostic laboratory for investigation of thyroid disease.…”