“…Fluid overload, in association with decreased plasma oncotic pressure secondary to hypoalbuminemia, can lead to pulmonary oedema, pleural effusions and lung congestion. Heart failure and other cardiac diseases, common findings in CKD, may also contribute to the development of congestive heart failure and may further complicate the aetiology of pulmonary oedema [9]. Furthermore, in patients with CKD the increase of pulmonary capillary permeability due to uremia and mediated by high plasma levels of endothelial cell-derived glycoproteins [von Willebrand Factor, tissue plasminogen activator, urokinase-type plasminogen activator, soluble thrombomodulin, endothelin-1, Intercellular Adhesion Molecule 1, Vascular cell adhesion protein 1, and Monocyte chemoattractant protein-1] and Vascular Endothelial Growth Factor further contributes to pulmonary congestion [10].…”