Usefulness of Neutrophil/Lymphocyte Ratio as a Predictor of Amputation after Embolectomy for Acute Limb Ischemia

Taşoğlu, İrfan; Çiçek, Ömer Faruk; Lafçı, Gökhan; Kadiroğulları, Ersin; Sert, Doğan Emre; Demir, Aslı; Çavuş, Umut Yücel; Çolak, Necmettin; Songür, Murat; Hodo, Bledar

doi:10.1016/j.avsg.2012.12.009

Cited by 54 publications

(54 citation statements)

References 23 publications

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“…19 Also in another study, preprocedural NLR ≥5.2 predicted early (within 30 days after surgery) and midterm (total) amputation with sensitivity and specificity of 83% and 64% and 63% and 63%, respectively. 29 Also, NLR >5.67 predicted mortality in acute ischemic stroke with sensitivity and specificity of 81.7% and 65.8%, respectively. 30 Our study suggests that the optimal NLR value for predicting diabetic foot ulcer healing is 4.2; however, this value by itself cannot predict diabetic foot ulcer healing with high sensitivity and specificity (63% and 71%).…”

Section: Discussionmentioning

confidence: 91%

Predictive value of neutrophil-to-lymphocyte ratio in diabetic wound healing

Vatankhah

Jahangiri

Landry

et al. 2017

Journal of Vascular Surgery

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Objective The neutrophil-to-lymphocyte ratio (NLR) has been used as a surrogate marker of systemic inflammation. We sought to investigate the association between NLR and wound healing in diabetic wounds. Methods The outcomes of 120 diabetic foot ulcers in 101 patients referred from August 2011 to December 2014 were examined retrospectively. Demographic, patient-specific, and wound-specific variables as well as NLR at baseline visit were assessed. Outcomes were classified as ulcer healing, minor amputation, major amputation, and chronic ulcer. Results The subjects’ mean age was 59.4 ± 13.0 years, and 67 (66%) were male. Final outcome was complete healing in 24 ulcers (20%), minor amputation in 58 (48%) and major amputation in 16 (13%), and 22 chronic ulcers (18%) at the last follow-up (median follow-up time, 6.8 months). In multivariate analysis, higher NLR (odds ratio, 13.61; P = .01) was associated with higher odds of nonhealing. Conclusions NLR can predict odds of complete healing in diabetic foot ulcers independent of wound infection and other factors.

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Section: Discussionmentioning

confidence: 91%

Predictive value of neutrophil-to-lymphocyte ratio in diabetic wound healing

Vatankhah

Jahangiri

Landry

et al. 2017

Journal of Vascular Surgery

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“…Twenty‐one potential papers were included in further review – 16 studies were then excluded: two studies had unclear patient population description with mixture of oncological cases and non‐oncological cases, one study was performed in head and neck cancer patients, four studies were diagnostic in nature, one study had unclear methodology, one study studied had an intermediate outcome, which does not meet the criteria of morbidity, and seven trials were retrospective in nature . Hence, five trials, studying a total of 3487 patients, met all the inclusion criteria (Fig.…”

Section: Resultsmentioning

confidence: 99%

Neutrophil–lymphocyte ratio as predictor of mortality and morbidity in cardiovascular surgery: a systematic review

Tan¹,

Arekapudi

Metha

et al. 2015

ANZ Journal of Surgery

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“…56 In a retrospective analysis of 254 patients who underwent embolectomy for ALI, a neutrophil / lymphocyte ratio > 5.2 had a sensitivity of 83% and a specificity of 63% to detect the need for amputation within 30 days. 57 There are no data in the literature correlating levels of lactate with severity of ALI. The 2017 ESVS Mesenteric Guidelines recommended against using serum lactate to diagnose acute mesenteric ischaemia, as it is a late sign of generalised hypoperfusion, and is often normal in the early acute phase.…”

Section: Laboratory Markers Of Ischaemiamentioning

confidence: 99%