Usefulness of oral medroxyprogesterone acetate in the management of cancer-related cachexia-anorexia syndrome

Management of Adverse Events Associated with Cabozantinib Therapy in Renal Cell Carcinoma

“…There is limited information on the weight maintenance strategies among patients receiving cabozantinib. Agents that help patients dealing with anorexia, or who need to gain weight and increase appetite, such as medroxyprogesterone acetate, could be assessed in this setting . Appetite loss may be associated with nausea.…”

Understanding and managing toxicities of vascular endothelial growth factor (VEGF) inhibitors

“…A randomised trial that aimed to identify the most effective among these strategies revealed the greatest benefits with a combination of all [124]. Medroxyprogesterone acetate (MPA) for instance was shown to increase body weight and appetite in patients with the cachexia–anorexia syndrome [125]. The underlying mechanism may involve a down-regulation of high serum levels of IL-6 and TNFα [124].…”