Usefulness of plasma brain natriuretic peptide levels in predicting dobutamine-induced myocardial ischemia

Asada, Junko; Tsuji, Hisako; Iwasaka, Toshiji; Thomas, James D.; Lauer, Michael S.

doi:10.1016/j.amjcard.2003.11.051

Cited by 38 publications

(23 citation statements)

References 10 publications

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“…Abbreviations: BNP, B-type natriuretic peptide; CHD, Coronary heart disease; ETT, electrocardiogram test; NT-proBNP, N-terminal proBNP Our study is in agreement with that reporting higher BNP concentrations but similar incremental BNP concentrations in patients with myocardial ischaemia compared with controls, 11 but differs from that reporting similar NTproBNP concentrations in patients with and without electrocardiographic myocardial ischaemia, 12 and also differs from those reporting increased incremental BNP responses in those with myocardial ischaemia compared with controls.…”

Section: Discussionsupporting

confidence: 82%

B-type natriuretic peptide in reversible myocardial ischaemia: Table 1

et al. 2006

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Background: Coronary heart disease is associated with increased B-type natriuretic peptides (BNPs), and, although controversial, may cause exaggerated exercise-induced BNP secretion. We investigated BNP in relation to reversible myocardial ischaemia. Materials and methods: Serum N-terminal proBNP (NTproBNP) was measured before and after an exercise electrocardiogram test (ETT) in 14 patients with and 45 patients without exercise-induced myocardial ischaemia. Statistical analysis was carried out on logarithmically transformed data. Results, however, are pre-transformed data.Results: NT-proBNP increased with exercise both in ETTpositive patients (mean (SD) 71.4 (41.2) v 76.8 (44.0) ng/l; p,0.001) and ETT-negative patients (54.0 (61.2) v 60.1 (69.0) ng/l; p,0.001). Pre-exercise and post-exercise NTproBNP were higher (p,0.05) in ETT-positive than in ETTnegative patients. Incremental NT-proBNP was similar in ETTpositive (4.7 (4.2) ng/l) and ETT-negative (6.2 (8.6) ng/l) patients. Conclusion: Serum NT-proBNP concentrations are higher in patients with exercise-induced myocardial ischaemia than in those without. Exercise-induced electrocardiographic myocardial ischaemia, however, is not associated with exaggerated BNP secretion.

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Section: Discussionsupporting

confidence: 82%

B-type natriuretic peptide in reversible myocardial ischaemia: Table 1

et al. 2006

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“…12 The more limited extent of ischemia may be reflected by the fact that BNP levels rise acutely during exercise but not during dobutamine-induced ischemia. [11][12][13][14] This finding is consistent with that of Ikonomidis et al, 2 who show that with larger induced ischemic territories the change in IL-6 level is greater. Many researchers in the fields of proteomics and metabolomics are actively pursuing biomarker strategies for assessing reversible and irreversible myocardial ischemia.…”

Section: Article P 3272supporting

confidence: 82%

Biomarkers of Ischemia in Patients With Known Coronary Artery Disease

2005

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“…[17][18][19][20][21] Other studies of stable subjects without acute coronary syndrome show that BNP and NT-proBNP predict all-cause mortality and cardiovascular events, although MI risk was not specifically examined in these studies. [7][8][9] Plasma BNP level predicted dopamineinduced myocardial ischemia in patients with known or suspected coronary heart disease, 32 suggesting that increased BNP levels may be associated with subclinical cardiac ischemia and therefore increased risk of MI. Our study provides additional new information by demonstrating that NT-proBNP predicts MI in stable patients, most of whom did not have a history of coronary heart disease.…”

Section: Discussionmentioning

confidence: 99%

Prediction of Myocardial Infarction by N-Terminal-Pro-B-Type Natriuretic Peptide, C-Reactive Protein, and Renin in Subjects With Cerebrovascular Disease

et al. 2005

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Background-B-type natriuretic peptide (BNP), C-reactive protein (CRP), and renin are elevated in persons at risk for cardiovascular disease. However, data that directly compare these markers in the prediction of myocardial infarction (MI) are limited. Methods and Results-N-terminal-proBNP (NT-proBNP), CRP, and renin were measured in baseline blood samples from a nested case-control study of the 6105 participants of the Perindopril Protection Against Recurrent Stroke Study (PROGRESS), a placebo-controlled study of a perindopril-based blood pressure-lowering regimen among individuals with previous stroke or transient ischemic attack. Each of 206 subjects who experienced MI, either fatal or nonfatal, during a mean follow-up of 3.9 years was matched to 1 to 3 control subjects. Most MI cases (67%) occurred in subjects without a history of coronary heart disease. NT-proBNP, CRP, and renin each predicted MI; the odds ratio for subjects in the highest compared with the lowest quarter was 2.2 (95% CI, 1.3 to 3.6) for NT-proBNP, 2.2 (95% CI, 1.3 to 3.6) for CRP, and 1.7 (95% CI, 1.1 to 2.8) for renin. NT-proBNP and renin, but not CRP, remained predictors of MI after adjustment for all other predictors, including LDL and HDL cholesterol levels. Individuals with both NT-proBNP and renin in their highest quarters had 4.5 times the risk of MI compared with subjects with both biological markers in their lowest quarters. Conclusions-NT-proBNP

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Usefulness of plasma brain natriuretic peptide levels in predicting dobutamine-induced myocardial ischemia

Cited by 38 publications

References 10 publications

B-type natriuretic peptide in reversible myocardial ischaemia: Table 1

B-type natriuretic peptide in reversible myocardial ischaemia: Table 1

Biomarkers of Ischemia in Patients With Known Coronary Artery Disease

Prediction of Myocardial Infarction by N-Terminal-Pro-B-Type Natriuretic Peptide, C-Reactive Protein, and Renin in Subjects With Cerebrovascular Disease

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