Usefulness of plateletcrit in the prediction of major adverse cardiac and cerebrovascular events in patients with carotid artery stenosis

Aslan, Serkan; Demir, Ali; Demir, Yusuf; Taşbulak, Ömer; Altunova, Mehmet; Karakayalı, Muammer; Yılmaz, Emre; Gürbak, İsmail; Ertürk, Mehmet

doi:10.1177/1708538119847898

Cited by 18 publications

(8 citation statements)

References 15 publications

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“…There was increasing evidence that platelet indices, including MPV and PCT, were found to be significantly associated with vascular risk factors 26 . In the study by Aslan et al 27 , 230 patients with carotid artery disease were included, and high PCT levels were demonstrated to be statistically higher in patients with major adverse cardiac and cerebrovascular events. Furthermore, a study showed that there was a strong relationship between PCT and saphenous vein disease and slow coronary flow 28 .…”

Section: Discussionmentioning

confidence: 99%

Does periodontitis affect mean platelet volume(MPV) and plateletcrit (PCT) levels in healthy adults?

Ustaoğlu

Erdal

İnanır

2020

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE Periodontitis may stimulate infectious and immune response and cause the development of atherogenesis, coronary heart disease, and myocardial infarction. The aim of this study was to compare the plateletcrit (PCT) and mean platelet volume (MPV) levels derived from complete blood count (CBC) tests in patients suffering from stage 3 periodontitis with those of healthy individuals without periodontal disease. METHODS The study included 57 patients (28 females and 29 males) with Stage 3 Periodontitis and 57 volunteering individuals (31 females and 26 males) who were periodontally healthy. The age of study participants ranged from 18 to 50 years. Their periodontal condition was investigated with probing depth (PD), clinical attachment level, bleeding on probing, and plaque index. Leukocyte (WBC) and erythrocyte count (RBC), hemoglobin (Hb) and hematocrit (HCT) levels, mean corpuscular volume (MCV) and red cell distribution width (RDW), thrombocyte count, mean platelet volume (MPV), plateletcrit (PCT ), and neutrophil and lymphocyte counts were evaluated based on the CBC test results of the study participants. RESULTS PCT, WBC, Neutrophil, and MPV values were found to be significantly higher in the periodontitis group (p<0.05). There were no significant differences in RBC counts, Hb, HCT, MCV, RDW, and platelet and lymphocyte counts between the two study groups (p>0.05). CONCLUSIONS PCT and MPV levels may be a more useful marker to determine an increased thrombotic state and inflammatory response in periodontal diseases.

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Section: Discussionmentioning

confidence: 99%

Does periodontitis affect mean platelet volume(MPV) and plateletcrit (PCT) levels in healthy adults?

Ustaoğlu

Erdal

İnanır

2020

Rev. Assoc. Med. Bras.

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“… 33 The results of our study demonstrated that T2DM patients with DPN had significantly higher fibrinogen, lower BMI, and slightly but not significantly decreased MPV and PDW, and BMI was positively associated with MPV and PDW (data not shown), indicating that obese patients have higher MPV and PDW levels than non-obese patients, and weight loss could lead to lower MPV levels, in agreement with previous studies. 38 , 39 Moreover, serum TBA levels were positively associated with MPV and PDW, and negatively with PLT, PCT and fibrinogen, and the subjects in the higher serum TBA quartiles exhibited higher levels of MPV and PDW, and lower PLT and fibrinogen compared with those in the lowest quartile, suggesting that serum TBA might exertathero-protective effects by inhibiting platelet activation and function. Previous studies also revealed that BAs were associated with platelet dysfunction through membrane deformity and inhibited the thrombin response, 40 , 41 and taurocholic acid reduced clot strength via inhibiting platelet activation and aggregation, and promoted tissue plasminogen activator-mediated fibrinolysis.…”

Section: Discussionmentioning

confidence: 97%

Decreased Physiological Serum Total Bile Acid Concentrations in Patients with Type 2 Diabetic Peripheral Neuropathy

Yan

Wan

Tang

et al. 2021

DMSO

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Purpose Bile acids, amphipathic cholesterol metabolites, have been reported to have cytoprotective and neuroprotective effects in humans and animal models. The relationship of physiological serum total bile acid (TBA) levels with diabetic peripheral neuropathy (DPN), however, has not been determined. The purpose of this study was to investigate the relationship between physiological serum TBA and DPN. Patients and Methods In total, 856 patients with type 2 diabetes mellitus (T2DM) aged 20–89 years were enrolled in this cross-sectional study. Serum TBA was measured, and its relationship with DPN and other parameters was analyzed. Results T2DM patients with DPN had significantly lower serum TBA compared with those without ( P <0.01). Serum TBA was negatively associated with glycated hemoglobin A1C, plateletcrit, fibrinogen, urine albumin-to-creatinine ratio, vibration perception thresholds, and prevalence of DPN, peripheral arterial disease, and diabetic foot ulceration after adjustment for age, sex, and body mass index ( P <0.01 or P <0.05). A graded association with prevalence of DPN and increase in serum TBA quartiles was observed ( P for trend <0.01), and there was an 48.2% decreased risk of DPN in the highest quartile of serum TBA versus the lowest quartile (95% CI 0.299–0.617; P =0.000) after multivariate adjustment. Receiver-operating characteristic analysis revealed that the optimal cutoff point of serum TBA to indicate DPN was 2.85 μmol/L (sensitivity 77.6% and specificity 45.6%). Conclusion These findings suggest that lower physiological serum TBA level may be associated with the prevalence of DPN in T2DM patients and may be a potential biomarker for DPN.

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“…In addition, the paper shows that there are obvious differences in age and hemogram between the population in control group and the population in first cerebral infarction. These biomarkers, including platelets, lymphocytes, neutrophils and monocytes, were good predictors for cerebrovascular events [ 24 ]. In the future, more large-scale research is needed to establish a model based on these indicators to predict cerebral infarction.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of (sdLDLc*HCYc)/HDLc ratio in clinical auxiliary diagnosis of primary cerebral infarction

Luo

Qian

et al. 2022

BMC Cardiovasc Disord

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Background Timely detection of cerebral infarction is of vital importance in planning intervention effect of rapid rehabilitation. The clinical auxiliary diagnosis value of single biomarker, including small dense low-density lipoprotein concentration (sdLDLc), homocysteine concentration (HCYc) and high-density lipoprotein cholesterol concentration (HDLc) for cerebral infarction has been confirmed by many studies. Whether the use of three biomarkers in combination by calculating (sdLDLc*HCYc)/HDLc ratio could improve the diagnosis ability for primary cerebral infarction remains to be unclear. In the present study, we conducted a cross-sectional study to evaluate the value of (sdLDLc*HCYc)/HDLc ratio in clinical auxiliary diagnosis of primary cerebral infarction. Methods A total of 583 participants, including 299 healthy participants as control group and 284 participants diagnosed with first cerebral infarction as experiment group, were included in this respective study. The serum sdLDLc, HDLc and HCYc were measured by peroxidase method, enzyme‐linked immunosorbent assay and an enzymatic method, respectively. Results The average concentration of sdLDL and HCY (0.69 ± 0.29 mmol/L and 18.14 ± 6.62 μmol/L) in experiment group was significantly higher than those in the control group (0.55 ± 0.22 mmol/L and 10.77 ± 2.67 μmol/L, P < 0.05). However, the average concentration of HDL (1.47 ± 0.25 mmol/L) in the control group was higher than that in the experiment group (1.33 ± 0.28 mmol/L, P < 0.05). Spearman correlation coefficient showed the three indicators are independent of each other. The positive predictive value of (sdLDLc*HCYc)/HDLc ratio (61.27%, 95% CI: 55.31–66.92) is higher than that in single biomarker (sdLDLc: 6.69 95% CI: 4.19–10.42, HCYc: 38.38%, 95% CI: 32.75–44.33, HDLc: 3.87%, 95% CI: 2.05–7.02). Receiver-operating characteristic curve (ROC) analysis illustrated that predictive power of (sdLDLc*HCYc)/HDLc was higher than single biomarker, including sdLDLc, HCYc and HDLc, in primary cerebral infarction. Conclusions Therefore, (sdLDLc*HCYc)/HDLc ratio might be a better new indicator in clinical auxiliary diagnosis of primary cerebral infarction, which could be contributed to predicting cerebral infarction occurrence and provide a scientific basis for early prevention.

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Usefulness of plateletcrit in the prediction of major adverse cardiac and cerebrovascular events in patients with carotid artery stenosis

Cited by 18 publications

References 15 publications

Does periodontitis affect mean platelet volume(MPV) and plateletcrit (PCT) levels in healthy adults?

Does periodontitis affect mean platelet volume(MPV) and plateletcrit (PCT) levels in healthy adults?

Decreased Physiological Serum Total Bile Acid Concentrations in Patients with Type 2 Diabetic Peripheral Neuropathy

Evaluation of (sdLDLc*HCYc)/HDLc ratio in clinical auxiliary diagnosis of primary cerebral infarction

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