Usefulness of procalcitonin for diagnosis of infective endocarditis

Jereb, Matjaž; Kotar, Tadeja; Jurca, Tomaž; Zupanc, Tatjana Lejko

doi:10.1007/s11739-009-0245-4

Cited by 23 publications

(21 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In total, six original studies and a meta-analysis evaluating PCT, were included here [5,6,[8][9][10][11][12]. Some studies argue for [5,11], and some against [6,[8][9][10], PCT routine testing of IE suspected patients to diagnose or exclude the condition. Two studies found the IE-group to have significantly increased PCT values compared to controls, such as 6.56 ng/mL vs. 0.44 ng/mL [11] and 0.21 ng/mL vs. 0.14 ng/mL [10].…”

Section: Procalcitonin (Pct)mentioning

confidence: 99%

A systematic review of biomarkers in the diagnosis of infective endocarditis

Snipsøyr

Ludvigsen

Petersen

et al. 2016

International Journal of Cardiology

View full text Add to dashboard Cite

Section: Procalcitonin (Pct)mentioning

confidence: 99%

A systematic review of biomarkers in the diagnosis of infective endocarditis

Snipsøyr

Ludvigsen

Petersen

et al. 2016

International Journal of Cardiology

View full text Add to dashboard Cite

“…Lastly, Jereb et al [49] evaluated the accuracy of procalcitonin (PCT) in predicting infective endocarditis (IE) in 23 adult patients with IE, 30 patients with sepsis and 30 with tick-borne encephalitis. sPCT level, C-reactive protein (CRP), total leukocytes, and immature polymorphonuclear (PMN) cell counts were determined on admission, prior to the institution of antibiotic therapy, and compared according to the diagnosis: the study fails to demonstrate the superiority of PCT as a diagnostic laboratory parameter in predicting IE compared to CRP.…”

Section: Procalcitonin After Cardiac Surgerymentioning

confidence: 99%

Procalcitonin in acute cardiac patients

et al. 2010

View full text Add to dashboard Cite

Procalcitonin (PCT) levels are below the detection level in healthy subjects, while pre-procalcitonin mRNA is over expressed in human medullar thyroid carcinoma, in small cell lung tumor, and occasionally in other rare neuroendocrine tumors such as phaeochromocytoma. PCT is known as a sensitive and specific biomarker for bacterial sepsis, being produced by extra-thyroidal parenchymal tissues, mainly hepatocytes. The increase in plasma level correlates with the severity of infection and the magnitude and the time course of its increase can be strictly related to the patient's outcome, and to the bacterial load. So far, data on serum PCT levels in patients with cardiogenic shock and in those with acute coronary syndromes (ACS) are scarce and controversial. While some studies report that PCT levels are increased in ACS patients on admission, other investigations document that plasma PCT concentrations are in the normal range. We recently reported that the degree of myocardial ischemia (clinically indicated by the whole spectrum of ACS, from unstable angina to cardiogenic shock following ST-elevation myocardial infarction) and the related inflammatory-induced response are better reflected by C-reactive protein (which was positive in most acute cardiac care patients of all our subgroups) than by PCT, which seems more sensitive to a higher degree of inflammatory activation, being positive only in patients with cardiogenic shock. Few studies investigated the dynamics of PCT in cardiac acute patients, and, despite the paucity of data and differences in patients' selection criteria, an increase in PCT values seems to be associated with the development of complications. In acute cardiac patients, the clinical values of procalcitonin rely not on its absolute value, but only on its kinetics over time.

show abstract

“…13) However, CRP is easier to measure in a blood sample than interleukin-6 in a general hospital. Jereb, et al 15) compared the accuracy of procalcitonin and CRP in diagnosing IE, but they failed to demonstrate superiority of procalcitonin as a diagnostic laboratorial parameter in predicting IE. 12,15) Based on these facts, we believe that a change in the time course of serum CRP levels is more suitable to guide therapeutic decisions in active IE than other indices.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Increasing C-reactive Protein Affects the Outcome for Active Infective Endocarditis

Okada

Hosono

Sasaki

et al. 2014

ATCS

View full text Add to dashboard Cite

Purpose: This study aimed to determine if preoperative time course changes in serum C-reactive protein (CRP) levels can predict clinical outcome of surgical intervention for active infective endocarditis. Methods: Surgically treated patients (n = 109) with active infective endocarditis were reviewed retrospectively. We divided the patients into 2 subgroups according to preoperative transition of increasing or decreasing serum CRP levels, and performed a comparative study. The increasing CRP group included 29 patients and the decreasing CRP group included 80 patients. Results: There were more patients with methicillin-resistant Staphylococcus aureus and New York Heart Association functional class IV in the increasing CRP group. Hospital mortality was significantly higher in the increasing CRP group (34.5%) than that in the decreasing CRP group (5.0%) (p <0.05). In multivariate analysis, 3 significant risk factors of surgical outcome were identified: a tendency for increasing preoperative CRP levels (odds ratio [

show abstract

Usefulness of procalcitonin for diagnosis of infective endocarditis

Cited by 23 publications

References 23 publications

A systematic review of biomarkers in the diagnosis of infective endocarditis

A systematic review of biomarkers in the diagnosis of infective endocarditis

Procalcitonin in acute cardiac patients

Preoperative Increasing C-reactive Protein Affects the Outcome for Active Infective Endocarditis

Contact Info

Product

Resources

About