Usefulness of Pseudocontinuous Arterial Spin-Labeling for the Assessment of Patients with Head and Neck Squamous Cell Carcinoma by Measuring Tumor Blood Flow in the Pretreatment and Early Treatment Period

Fujima, Noriyuki; Yoshida, Daisuke; Sakashita, Tetsuya; Homma, Akihiro; Tsukahara, Akiko; Tha, Khin Khin; Kudo, Kohsuke; Shirato, Hiroki

doi:10.3174/ajnr.a4513

Cited by 31 publications

(25 citation statements)

References 32 publications

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“…Previous studies on NPC [16,18] applied ASL with PLD of 1025 ms, 1525 ms, and 2025 ms. The optimal selection of PLD is 1025 ms due to its best performance on evaluating perfusion and delineating the volume of NPC, which was also similar to previous studies on malignant tumors of nasal cavity and neck with PLD of 1280 ms [20,36].…”

Section: Discussionsupporting

confidence: 80%

Investigating the value of arterial spin labeling and intravoxel incoherent motion imaging on diagnosing nasopharyngeal carcinoma in T1 stage

et al. 2020

Cancer Imaging

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Background: To investigate the diagnostic value of arterial spin labeling (ASL) and intravoxel incoherent motion (IVIM) imaging in distinguishing nasopharyngeal carcinoma (NPC) in T1 stage from healthy controls (HC). Methods: Forty-five newly diagnosed NPC patients in the T1 stage and thirty-one healthy volunteers who underwent MR examinations for both 3D pseudo-continuous ASL (pCASL) and IVIM were enrolled in this study. The Mann-Whitney test was used to compare the mean values of blood flow (BF) derived from pCASL and IVIM derived parameters, including apparent diffusion coefficient (ADC), pure molecular diffusion (D), pseudo-diffusion coefficient (D*) and perfusion fraction (f) between NPC tumor and benign nasopharyngeal mucosa of HC. Receiver Operating Characteristic (ROC) was performed to determine diagnostic cutoff and efficiency. The correlation coefficients among parameters were investigated using Spearman's test. Results: The NPC in the T1 stage showed higher mean BF, lower ADC, D, and f compared to benign nasopharyngeal mucosa (P < 0.001) with the area under curve of ROC of 0.742-0.996 (highest by BF). BF cutoff was set at > 36 mL/100 g/min; the corresponding sensitivity, specificity, and accuracy in differentiating NPC stage T1 from benign nasopharyngeal mucosa were 95.56% (43/45), 100% (31/31) and 97.37% (74/76), respectively. BF demonstrated moderate negative correlation with D* on HC (ρ [Spearman correlation coefficients] = − 0.426, P = 0.017). Conclusions: ASL and IVIM could reflect the difference in perfusion and diffusion between tumor and benign nasopharyngeal mucosa, indicating a potential for accessing early diagnosis of NPC. Notably, BF, with a specificity of 100%, demonstrated better performance compared to IVIM in distinguishing malignant lesions from healthy tissue.

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Section: Discussionsupporting

confidence: 80%

Investigating the value of arterial spin labeling and intravoxel incoherent motion imaging on diagnosing nasopharyngeal carcinoma in T1 stage

et al. 2020

Cancer Imaging

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“…In the current study, the semi-quantitative morphological parameter of sphericity was revealed to be a clinically useful predictor of treatment outcome in patients with nasal-or paranasal-cavity SCC. The difficulty of using pretreatment parameters to predict treatment outcome in advancedstage SCC patients receiving curative chemoradiation with arterial cisplatin infusion has been demonstrated, although a few reports have described the utility of tumor blood flow or tumor micro-water diffusion as an evaluation tool during treatment using MRI (21,22). The results of the current study will provide supporting information for the prediction of treatment outcome; this information can be used for the adjustment of treatment regimens such as the addition of induction chemotherapy before curative therapy consisting of chemotherapy and concomitant full-dose radiotherapy, or the determination of a follow-up strategy after the treatment.…”

Section: Discussionmentioning

confidence: 99%

Semi-quantitative analysis of pre-treatment morphological and intratumoral characteristics using 18F-fluorodeoxyglucose positron-emission tomography as predictors of treatment outcome in nasal and paranasal squamous cell carcinoma

Fujima

Hirata

Shiga

et al. 2018

Quant. Imaging Med. Surg.

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Background: To investigate the utility of quantitative morphological and intratumoral characteristics obtained by 18 F-fluorodeoxyglucose positron-emission tomography/computed tomography (FDG-PET/CT) for the prediction of treatment outcome in patients with nasal or paranasal cavity squamous cell carcinoma (SCC). Methods: Twenty-four patients with nasal or paranasal cavity SCC who received curative non-surgical therapy (a combination of super-selective arterial cisplatin infusion and radiotherapy) were retrospectively analyzed. From pre-treatment FDG-PET data, a total of 13 parameters of quantitative morphological characteristics (tumor volume, surface area and sphericity), intratumoral characteristics (the maximum and mean standard uptake value, three intratumoral histogram and four textural parameters) and total lesion glycolysis (TLG) were respectively calculated. Information regarding the treatment outcome was determined from the histological diagnosis or clinical follow-up. Each of the 13 quantitative parameters as well as T-and N-stage was assessed for its relation to treatment outcome of local control or failure. Results: In univariate analysis, significant differences in surface area and sphericity between the local control and failure groups were observed. The receiver operating characteristic (ROC) curve analysis showed that sphericity had the highest accuracy of 0.88. In the multivariate analysis, sphericity was revealed as an independent predictor of the local control or failure. Conclusions: The quantitative parameters of sphericity are useful to predict the treatment outcome in patients with nasal or paranasal SCC.

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“…A primary lesion site in the larynx generally suffered from respiratory motion, and thus patients with this primary site were excluded. Nasal and paranasal sinus SCC patients were also excluded because the biological characteristics of these lesions are somewhat different from SCCs of the abovementioned primary sites [12]. In addition, some of the oropharyngeal SCC patients ( n = 21) in the total study population received a diagnosis of human papillomavirus status from their histological samples by biopsy with the use of immunohistochemistry for p16.…”

Section: Methodsmentioning

confidence: 99%

The utility of MRI histogram and texture analysis for the prediction of histological diagnosis in head and neck malignancies

et al. 2019

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BackgroundTo assess the utility of histogram and texture analysis of magnetic resonance (MR) fat-suppressed T2-weighted imaging (Fs-T2WI) for the prediction of histological diagnosis of head and neck squamous cell carcinoma (SCC) and malignant lymphoma (ML).MethodsThe cases of 57 patients with SCC (45 well/moderately and 12 poorly differentiated SCC) and 10 patients with ML were retrospectively analyzed. Quantitative parameters with histogram features (relative mean signal, coefficient of variation, kurtosis and skewness) and gray-level co-occurrence matrix (GLCM) features (contrast, correlation, energy and homogeneity) were calculated using Fs-T2WI data with a manual tumor region of interest (ROI).ResultsThe following significantly different values were obtained for the total SCC versus ML groups: relative mean signal (3.65 ± 0.86 vs. 2.61 ± 0.49), contrast (72.9 ± 16.2 vs. 49.3 ± 8.7) and homogeneity (2.22 ± 0.25 × 10− 1 vs. 2.53 ± 0.12 × 10− 1). In the comparison of the SCC histological grades, the relative mean signal and contrast were significantly lower in the poorly differentiated SCC (2.89 ± 0.63, 56.2 ± 12.9) compared to the well/moderately SCC (3.85 ± 0.81, 77.5 ± 13.9). The homogeneity in poorly differentiated SCC (2.56 ± 0.15 × 10− 1) was higher than that of the well/moderately SCC (2.1 ± 0.18 × 10− 1).ConclusionsParameters obtained by histogram and texture analysis of Fs-T2WI may be useful for noninvasive prediction of histological type and grade in head and neck malignancy.

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Usefulness of Pseudocontinuous Arterial Spin-Labeling for the Assessment of Patients with Head and Neck Squamous Cell Carcinoma by Measuring Tumor Blood Flow in the Pretreatment and Early Treatment Period

Cited by 31 publications

References 32 publications

Investigating the value of arterial spin labeling and intravoxel incoherent motion imaging on diagnosing nasopharyngeal carcinoma in T1 stage

Investigating the value of arterial spin labeling and intravoxel incoherent motion imaging on diagnosing nasopharyngeal carcinoma in T1 stage

Semi-quantitative analysis of pre-treatment morphological and intratumoral characteristics using 18F-fluorodeoxyglucose positron-emission tomography as predictors of treatment outcome in nasal and paranasal squamous cell carcinoma

The utility of MRI histogram and texture analysis for the prediction of histological diagnosis in head and neck malignancies

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