Usefulness of pulsed Doppler tissue imaging for noninvasive detection of cardiac rejection after heart transplantation

Fábregas, Ramón; Crespo-Leiro, María G.; Muñiz, Javier; Regueiro, Miguel; Rodríguez, José A.; Alvarez, Nélida María Cruz; Peteiro, Jesús; Paniagua, María; Vazquez, Jose M.; Cuenca, José; Castro‐Beiras, Alfonso

doi:10.1016/s0041-1345(99)00493-5

Cited by 23 publications

(11 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Three smaller studies have also demonstrated that Em significantly reduced in allograft rejection (23,38,39). On the other hand, other studies on 1500 biopsies in nearly 450 patients reported no association between acute allograft rejection and Em (40)(41)(42)(43)(44)(45)(46). Our study found that both tricuspid and mitral annular early (Em), but not late (Am), diastolic velocities were significantly different in the patients with acute allograft rejection.…”

Section: Discussionsupporting

confidence: 59%

Evaluation of the Role of Conventional and Tissue Doppler Imaging Echocardiography in Detection of Acute Cardiac Allograft Rejection in Heart Transplant Recipients

Haghighi

Amin

Chitsazan

et al. 2016

Int Cardiovasc Res J

View full text Add to dashboard Cite

A B S T R A C T Background: Endomyocardial Biopsy (EMB) is the gold standard test for diagnosis of acute allograft cardiac rejection.Objectives: The present study aimed to assess the role of echocardiographic parameters in discriminating patients with and without evidence of acute cardiac allograft rejection. Materials and Methods: In the present cross-sectional study, using convenience sampling, 63 EMB specimens were collected from the patients who had undergone biatrial orthotropic cardiac transplantation. The mean age of the recipients and donors was 30.46 ± 9.49 and 24.55 ± 7.64 years, respectively. There were 51(81%) male recipients and 39(62%) male donors. Echocardiographic examination was performed within the 24 hours of EMB. The data were entered into the SPSS statistical software, version 19 and were analyzed by chi-square test, student's t-test, and one-way ANOVA as appropriated. All the data were two-tailed and P < 0.05 was considered to be statistically significant. Results: Among the 63 EMB specimens evaluated in the present study, mild and moderate acute rejections were seen in 19(30%) and 5(8%) cases, respectively. On Doppler examination, the three groups (without rejection, with mild rejection, and with moderate acute rejection) were significantly different only regarding trans-tricuspid E wave (P = 0.040). Pulsed-wave Tissue Doppler Imaging (TDI) also revealed a significant difference between the patients with and without allograft rejection regarding early diastolic tricuspid and mitral annular motion velocities (P = 0.005 and P = 0.02, respectively). Conclusions: It seems that echocardiographic parameters, including TDI, might be adjunct to, rather than substitution for, EMB findings for early diagnosis of acute allograft rejection. BackgroundCardiac transplantation is considered to be a life-saving treatment option for patients with end-stage heart failure. However, rejection occurs in most patients. Cardiac allograft rejection is classified into three major categories, namely hyperacute, acute, and chronic. Hyperacute rejection occurs within minutes to hours after transplantation and ►Implication for health policy/practice/research/medical education:Cardiac transplantation is a life-saving treatment option for patients with end-stage heart failure. Despite advanced immunosuppressive regimes, acute cardiac allograft rejection is still the major cause of morbidity and mortality in the first year post-transplantation. Identification of patients at an earlier stage would prevent progression to more severe disease and ultimately reduces the risk of long-term complications. In the present study, we assessed the clinical applicability of tissue Doppler imaging techniques in the early diagnosis of acute cardiac allograft rejection.

show abstract

Section: Discussionsupporting

confidence: 59%

Evaluation of the Role of Conventional and Tissue Doppler Imaging Echocardiography in Detection of Acute Cardiac Allograft Rejection in Heart Transplant Recipients

Haghighi

Amin

Chitsazan

et al. 2016

Int Cardiovasc Res J

View full text Add to dashboard Cite

show abstract

“…27 Diastolic LVPWmax, determined by TDI in this study, had no predictive value for cellular rejection in pediatric recipients, in contrast to its reported value in adult recipients, 9 although its clinical value has been questioned. 29 It is not clear why diastolic LVPWmax, determined by TDI, had no predictive value for rejection, because diastolic LVPWmax, determined by M mode, has shown 9 ] vs 106.5 Ϯ 22 mm/s, Table 2) than reported herein, although diastvelLVPWmax TDI in one preliminary report was 113 Ϯ 22 mm/s in adult recipients, 32 closer to the values reported for pediatric recipients. In fact, diastvelLVPWmax of Ͻ160 mm/s had a negative predictive value of 92% for rejection.…”

Section: Discussionmentioning

confidence: 49%

Diastolic performance assessed by tissue Doppler after pediatric heart transplantation

Asante‐Korang¹,

Fickey²,

Boucek³

et al. 2004

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

“…3,4 In adult populations, early studies have indicated a high diagnostic accuracy of tissue Doppler imaging to detect acute cardiac allograft rejection, approaching the precision of invasive tests. [5][6][7][8] Pediatric heart transplant patients may be among those who would benefit most from a robust, noninvasive rejection marker such tissue Doppler imaging. Children now constitute 10.9% of all heart transplant recipients.…”

mentioning

confidence: 99%

Non-Invasive Detection of Acute Allograft Rejection in Children by Tissue Doppler Imaging: Myocardial Velocities and Myocardial Acceleration During Isovolumic Contraction

Pauliks

Pietra

DeGroff

et al. 2005

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

Usefulness of pulsed Doppler tissue imaging for noninvasive detection of cardiac rejection after heart transplantation

Cited by 23 publications

References 6 publications

Evaluation of the Role of Conventional and Tissue Doppler Imaging Echocardiography in Detection of Acute Cardiac Allograft Rejection in Heart Transplant Recipients

Evaluation of the Role of Conventional and Tissue Doppler Imaging Echocardiography in Detection of Acute Cardiac Allograft Rejection in Heart Transplant Recipients

Diastolic performance assessed by tissue Doppler after pediatric heart transplantation

Non-Invasive Detection of Acute Allograft Rejection in Children by Tissue Doppler Imaging: Myocardial Velocities and Myocardial Acceleration During Isovolumic Contraction

Contact Info

Product

Resources

About