Usefulness of Restless Legs Symptoms to Predict Adverse Cardiovascular Outcomes in Men With Coronary Artery Disease

Almuwaqqat, Zakaria; Kim, Jeong Hwan; Islam, Shabatun; Mehta, Anurag; Ahmad, Syed Furquan; Wehbe, Mohamad; Hazim, Katrina; Dhindsa, Devinder S.; Beydoun, Nour; Lemma, Martha Tibebu; Ejaz, Kiran; Ali, Syed Zain; Alkhoder, Ayman; Tahhan, Ayman Samman; Zaheer, Eesha A; Vatsa, Nishant; Ko, Yi-An; Sperling, Laurence; Rye, David B.; Quyyumi, Arshed A.

doi:10.1016/j.amjcard.2021.08.054

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Heart rate is an important physiological parameter that is closely related to blood pressure regulation and cardiovascular function [8,9]. Previous studies have suggested that elevated nocturnal heart rate (NHR) is associated with an increased risk of cardiovascular events and mortality in hypertensive patients [10][11][12][13][14][15]. However, the predictive value of NHR on the development and progression of TOD in hypertensive patients is not well established.…”

Section: Introductionmentioning

confidence: 99%

The Potential of Nocturnal Heart Rate as a Predictor of Target Organ Damage in Individuals Diagnosed with Hypertension

2023

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Background: Elevated nocturnal heart rate (NHR) has been linked to an increased risk of cardiovascular events and mortality in hypertensive patients. However, the ability of NHR to predict the occurrence and progression of target organ damage (TOD) in these patients requires further investigation. This study aims to evaluate the predictive value of NHR in forecasting the presence and severity of TOD in hypertensive patients, using a combination of clinical and laboratory parameters. Methods: A total of 145 hypertensive patients were monitored for blood pressure and nocturnal heart rate. Patients were categorized into two groups based on the presence or absence of TOD and their NHR. The left ventricular mass index (LVMI), glomerular filtration rate (GFR), carotid intima media index (CTIM), and left ventricular ejection fraction (LVEF) were measured, and multiple linear regression was used to determine the predictive value of NHR on these indices. Results: The group with TOD had significantly higher NHR than the group without TOD. LVMI, GFR, CTIM, and LVEF varied significantly among the three subgroups, with the NHR3 group showing marked differences compared to the NHR2 and NHR1 groups (p < 0.01 or p < 0.05). Excessively rapid NHR had diverse impacts on all categories of target organs, particularly on LVMI and CTIM. Conclusion: Augmentation of nocturnal heart rate causes heightened harm to the target organs, with the most significant impact observed in LVMI and CTIM. No significant difference in the severity of TOD was observed between patients with an NHR of less than 70 bpm and those with an NHR between 70 and 80 bpm. However, an NHR above 80 bpm resulted in more severe TOD. These findings suggest that monitoring NHR in hypertensive patients may help prevent and manage TOD.

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Section: Introductionmentioning

confidence: 99%

The Potential of Nocturnal Heart Rate as a Predictor of Target Organ Damage in Individuals Diagnosed with Hypertension

2023

medsc

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Cardiovascular Implications of Sleep Disorders Beyond Sleep Apnea

Park,

Yoon,

Liu

et al. 2024

Curr Sleep Medicine Rep

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Current updates in Restless Legs Syndrome: A pragmatic review

Makharia,

Agarwal,

Srivastava

et al. 2024

Ann Mov Disord

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Restless legs syndrome (RLS), also called Willis–Ekbom disease (WED), affects approximately 3% of the global population, with higher incidence in Caucasians and women. This review explores the latest advancements in the diagnosis, pathophysiology, and management of RLS, and it highlights the recent changes in diagnostic criteria that improve specificity. The diagnostic spectrum now includes atypical presentations involving the upper limbs and other body parts. The new diagnostic specifiers categorize RLS more effectively into chronic-persistent or intermittent types, and a clinical significance specifier has been introduced to better address the disorder’s effects on daily life. RLS management has shifted toward a balanced approach with non-pharmacological strategies and lifestyle changes, supported by updated pharmacological treatment protocols including iron therapy designed to mitigate risks such as augmentation. Notably, gabapentinoids have emerged as a superior treatment option over dopamine agonists owing to their lower risk of augmentation and superior safety profile. Innovative treatments, such as the FDA-approved tonic motor activation device and new pharmacological agents, serve as alternatives for treating medication-refractory RLS, thereby expanding the therapeutic landscape. Additionally, this review addresses the specific considerations for managing RLS in special groups, including pregnant women, individuals with chronic kidney disease, and patients with comorbid conditions such as Parkinson’s disease and multiple sclerosis. We emphasizes the dynamic nature of RLS research and highlight the critical need for ongoing studies to further elucidate the complex mechanisms underlying RLS, as well as to refine the treatment modalities to enhance patient outcomes.

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Usefulness of Restless Legs Symptoms to Predict Adverse Cardiovascular Outcomes in Men With Coronary Artery Disease

Cited by 3 publications

References 28 publications

The Potential of Nocturnal Heart Rate as a Predictor of Target Organ Damage in Individuals Diagnosed with Hypertension

The Potential of Nocturnal Heart Rate as a Predictor of Target Organ Damage in Individuals Diagnosed with Hypertension

Cardiovascular Implications of Sleep Disorders Beyond Sleep Apnea

Current updates in Restless Legs Syndrome: A pragmatic review

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