Usefulness of Serum Alkaline Phosphatase in Predicting Osteopenia and Rickets in Very Low Birth Weight Infants

Oh, Burm Seok; Choi, Jieun; Kim, Young Nam; Song, Eun Song; Choi, Young Youn

doi:10.5385/jksn.2012.19.4.229

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…12 A retrospective review by Burm seok et al between 2009 and 2011 revealed 43% (112/258) incidence of osteopenia. 20 During the study period radiology was the only tool to make definitive evidence of osteopenia. So, radiation hazard of X-ray could not be avoided in studied infants.…”

Section: Discussionmentioning

confidence: 99%

Biochemical Bone Markers for Early Detection of Osteopaenia of Prematurity

Jahan¹,

Mannan²,

Dey³

et al. 2017

Bangladesh Med Res Counc Bull

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Osteopenia of prematurity (OOP) imposes the risk of fractures and growth failure to premature infants. Studies have investigated the validity of biochemical markers of osteopenia but till date it is not established. So, this study was intended to examine the diagnostic performance of biochemical markers in early detection of osteopenia of prematurity. This prospective study was conducted in the Neonatal Intensive Care Unit (NICU), Department of Neonatology, Bangabandhu Sheikh Mujib Medical University during June 2013 to February 2014. A total of 100 premature infants with gestational age ≤ 34 weeks were consecutively included over 9 months period. Serum alkaline phosphatase, serum calcium and serum inorganic phosphates were measured from 1 week of chronological age until corrected term age. At corrected term age, radiologic examination was done for the assessment of osteopenia. Of the enrolled infants, 36/78 (46%) developed radiological evidence of osteopenia. Serum inorganic phosphate level was significantly less in osteopenic infants than non-osteopenic infants throughout first two months of life (p <0.001). The area under ROC curve for serum inorganic phosphate was 85% (p = 0.001). If the cut off value of serum inorganic phosphate was set at 3.6 mg/dl, then a sensitivity of 86% and a specificity of 49% were obtained. Low serum inorganic phosphate at 3 weeks of life can be used as a marker for early detection of osteopenia of prematurity.

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Section: Discussionmentioning

confidence: 99%

Biochemical Bone Markers for Early Detection of Osteopaenia of Prematurity

Jahan¹,

Mannan²,

Dey³

et al. 2017

Bangladesh Med Res Counc Bull

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show abstract

Risk Factors for Rickets of Prematurity in Extremely Low Birth Weight Infants

et al. 2015

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Purpose: This study aimed to analyze the risk factors for the development of rickets of prematurity in extremely low birth weight (ELBW) infants. Methods: We retrospectively reviewed the data of 57 ELBW infants. Nineteen infants were diagnosed with rickets and 38 infants without rickets were recruited. On radio logic evaluation, 47% of infants had grade I, 37% had grade II, and 16% had grade III rickets. Results:In ELBW infants with rickets, the durations of oxygen administration, mecha nical ventilation, parenteral nutrition, and hospitalization were significantly longer compared to those of the control group. The number of days for achieving an enteral caloric intake of 80 kcal/kg/d and the number of days for regaining birth weight were significantly longer compared to those of the control group. Serial weight changes from birth weight during 8 weeks after birth was significantly lower in the rickets group than in the control group. Retinopathy of prematurity was signi ficantly higher in the rickets group than in the control group. After adjustment for birth weight, rickets of prematurity was correlated with days for regaining birth weight (odds ratio [OR], 1.316; P=0.010), and with weight changes from birth weight at 4 weeks of age (OR, 0.964; P=0.033). Conclusion:In ELBW infants, the risk factors for rickets of prematurity were days for regaining birth weight from birth and the weight changes at 4 weeks of age. Early aggressive nutrition for regaining birth weight earlier may reduce the development of rickets of prematurity.

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Usefulness of Serum Alkaline Phosphatase in Predicting Osteopenia and Rickets in Very Low Birth Weight Infants

Cited by 2 publications

References 33 publications

Biochemical Bone Markers for Early Detection of Osteopaenia of Prematurity

Biochemical Bone Markers for Early Detection of Osteopaenia of Prematurity

Risk Factors for Rickets of Prematurity in Extremely Low Birth Weight Infants

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