Usefulness of Serum N-terminal–ProBNP in Distinguishing Ascites Due to Cirrhosis From Ascites Due to Heart Failure

Sheer, Todd A.; Joo, Elliot; Runyon, Bruce A.

doi:10.1097/mcg.0b013e318198113b

Cited by 26 publications

(23 citation statements)

References 18 publications

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Section: Discussionsupporting

confidence: 82%

“…This results matched with several studies [12,13]. Our study was in agreement with Sheer et al [12] where serum and ascitic fluid NT-proBNP concentrations were found to be closely related and had similar Figure 1: Serum and ascitic NT-proBNP levels in heart failure group were significantly higher than that in liver cirrhosis group (P < 0.001 for both). 36 (72) 14 (28) 22 (73.3) 8 (26.7) 18 (75) Our results were in a concordance with previous studies [12,14] that serum and ascitic fluid NT-proBNP levels with cut-off value greater than 1000 pg/ml was sensitive and specific in distinguishing patients with heart failure from those with concurrent extracellular volume overload in decompensated liver cirrhosis.…”

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

N-Terminal Pro-Brain Natriuretic Peptide: Prognostic Potential in End Stage Liver Cirrhosis in a Cohort Free of Heart Failure; an Egyptian Insight

Hassan¹,

Rehim²

2013

J Liver

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 82%

N-Terminal Pro-Brain Natriuretic Peptide: Prognostic Potential in End Stage Liver Cirrhosis in a Cohort Free of Heart Failure; an Egyptian Insight

Hassan¹,

Rehim²

2013

J Liver

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“…Jugular venous distension is present in the former but not in the latter. Also measurement of a blood concentration of brain natriuretic peptide or pro–brain natriuretic peptide can help distinguish ascites due to heart failure from ascites due to cirrhosis 14. The median pro–brain natriuretic peptide concentration is 6100 pg/mL in the former and only 166 pg/mL in the latter 14…”

Section: Evaluation and Diagnosismentioning

confidence: 99%

Management of adult patients with ascites due to cirrhosis

2009

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“…Using a value of 1000 pg/ml, the sensitivity of serum NT-proBNP in distinguishing ascites due to cirrhosis from ascites due to heart failure was 100% [14]. Most patients with acute decompensated heart failure have high liver stiffness values which, like NT-proBNP levels tend to decrease with clinical improvement [15].…”

Section: Discussionmentioning

confidence: 99%

Predictors of cardiac hepatopathy in patients with right heart failure

et al. 2011

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SummaryBackgroundSome patients with right heart failure develop cardiac hepatopathy (CH). The pathophysiology of CH is thought to be secondary to hepatic venous congestion and arterial ischemia. We sought to define the clinical and hemodynamic characteristics associated with CH.Material/MethodsA retrospective cross sectional analysis was performed in which subjects were identified from our institutional cardiology database if echocardiography showed either right ventricular (RV) hypokinesis or dilatation, and was performed within 30 days of right heart catheterization. A chart review was then performed to identify patient clinical characteristics and to determine if the patients had underlying liver disease. Subjects with non-cardiac causes for hepatopathy were excluded.ResultsIn 188 included subjects, etiology for right heart dysfunction included left heart failure (LHF), shunt, pulmonary hypertension, mitral- tricuspid- and pulmonic valvular disease. On multivariate analysis, higher RV diastolic pressure and etiology for RV dysfunction other than LHF were both associated with CH. Low cardiac output was associated with CH only amongst those without LHF.ConclusionsCH is most often seen in subjects with elevated RV diastolic pressure suggesting a congestive cause in most cases. CH associated with low cardiac output in patients without LHF suggests that low flow may be contributing to the patophysiology in some cases.

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Usefulness of Serum N-terminal–ProBNP in Distinguishing Ascites Due to Cirrhosis From Ascites Due to Heart Failure

Abstract: Serum NT-proBNP seems to be an extremely powerful marker in distinguishing ascites due to cirrhosis from ascites due to heart failure. Serum NT-proBNP may potentially replace the more invasive testing presently in use.

Cited by 26 publications

References 18 publications

N-Terminal Pro-Brain Natriuretic Peptide: Prognostic Potential in End Stage Liver Cirrhosis in a Cohort Free of Heart Failure; an Egyptian Insight

N-Terminal Pro-Brain Natriuretic Peptide: Prognostic Potential in End Stage Liver Cirrhosis in a Cohort Free of Heart Failure; an Egyptian Insight

Management of adult patients with ascites due to cirrhosis

Predictors of cardiac hepatopathy in patients with right heart failure

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