Usefulness of serum procalcitonin as a diagnostic biomarker of infection in children with chronic kidney disease

Fadel, Fatina; Elshamaa, Manal F.; Elghoroury, Eman A.; Badr, Amr; Kamel, Solaf; El-Sonbaty, Marwa M.; Raafat, Mona; Farouk, Hebatallh

doi:10.5114/amsad.2016.59672

Cited by 13 publications

(7 citation statements)

References 56 publications

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“…, 39. ] [ 47 ] [ 55 ] Procalcitonin Meningitis Serum ELISA 370 + + 66.7 59.3 60 ng/dl [ 104 ] SBI and IBI Serum ELISA 2047 + 90 78 ≥0.3 ng/ml [ 40 ] DCLD Serum Immunoluminometric assay 164 + 86.8 91.7 >0.5 ng/ml [ 36 ] CKD Serum ELISA 102 + 94.1 87.9 0.5 ng/ml [ 35 ] Meningitis Serum Immunoluminometric assay 616 + 96 89 [ 42 ] Bacteremia Serum Electrochemiluminescence immunoassay 65 + 81 68 0.25 μg/l [ 46 ] IL-6 Bacterial sepsis Serum ELISA 80 + 100 62.86 >51.29 pg/ml [ 47 ] Bacteremia Serum Electrochemiluminescence immunoassay 62 + 64 88 …”

Section: Bacterial Protein Biomarkersmentioning

confidence: 99%

Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing

Tsao

Tsai

Liao

et al. 2020

Trends in Molecular Medicine

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Children suffering from infectious diseases, both bacterial and viral, are often treated with empirical antibiotics. Keeping in mind both the menace of microorganisms and antibiotic toxicity, it is imperative to develop point-of-care testing (POCT) to discriminate bacterial from viral infections, and to define indications for antibiotic treatment. This article reviews potential protein biomarkers and host-derived gene expression signatures for differentiating between bacterial and viral infections in children, and focuses on emerging multiplex POCT devices for the simultaneous detection of sets of protein biomarkers or streamlined gene expression signatures that may provide rapid and cost-effective pathogen-discriminating tools.

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Section: Bacterial Protein Biomarkersmentioning

confidence: 99%

Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing

Tsao

Tsai

Liao

et al. 2020

Trends in Molecular Medicine

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“…Procalcitonin (proCT) is an acute phase protein consisting of 116 amino acids and is the precursor of the hormone calcitonin [11]. It has gained acceptance in obstetric practice since it was shown to rise at 3 to 6 h following bacterial infections and is a sensitive biomarker that differentiates bacterial infections from non-bacterial ones and other inflammatory states [12]. In this study we aimed to determine whether maternal serum proCT levels are useful in the prediction of chorioamnionitis in patients with PPROM.…”

Section: Introductionmentioning

confidence: 99%

Maternal serum procalcitonin levels in prediction of chorioamnionitis in women with preterm premature rupture of membranes

Bakar

Köroğlu

Turkgeldi³

et al. 2021

Arch Med Sci

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Introduction: Chorioamnionitis is one of the most important maternal complications in the expectant management of patients with preterm premature rupture of membranes (PPROM). Procalcitonin (proCT), the precursor of the hormone calcitonin, is used to differentiate bacterial infections from non-bacterial ones. The objective of the study was to determine the efficacy of maternal serum procalcitonin levels in the early prediction of chorioamnionitis in women with PPROM. Material and methods: The study was conducted in 76 pregnant women hospitalized due to PPROM at the maternal-fetal medicine unit of a tertiary center in Istanbul. Patients were followed up with white blood cell (WBC), C-reactive protein (CRP) and proCT levels every 2 days. The values of investigated parameters were recorded at the diagnosis of PPROM and at the time of delivery. The maximum values during the follow-up period were also recorded. Results: Out of the 76 patients with PPROM, 15 (19.73%) developed clinical chorioamnionitis. No significant difference could be detected in the gravidity, parity, duration of hospitalization and gestational week at diagnosis between those patients who developed clinical chorioamnionitis and those who did not. The WBC at the time of hospital admittance and before delivery, and CRP levels before delivery were statistically higher in the chorioamnionitis group (p < 0.05). No difference in the proCT levels could be detected either at the time of hospital admittance or before delivery between the two groups. Conclusions: Maternal proCT was not found to be predictive of chorioamnionitis. However, since there are reports in the literature that contradict these results, further studies are warranted to determine the true efficacy of proCT in the prediction of clinical chorioamnionitis.

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“…In our study, the PCT had not good results in comparison to culture results, but better results were seen when compared by SIRS. In the study by Fadel et al (35) among 102 patients of CKD with 34 culture positive cases showed sensitivity and specificity of 94% and 88% for PCT with a cut of point of 0.5, respectively. These results were low in our study compared to the culture results, but improved by SIRS.…”

Section: Discussionmentioning

confidence: 96%

Diagnostic value of serum procalcitonin for diagnosis of bacterial infection in patients with chronic kidney disease under hemodialysis

et al. 2020

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Introduction: Bacterial infections are common causes of mortality and morbidity among chronic kidney disease (CKD) patients under hemodialysis. Objectives: In this study the diagnostic value of serum procalcitonin for diagnosis of bacterial infections in patients with CKD under hemodialysis was assessed. Patients and Methods: In this cross-sectional comparative investigation, 47 patients with CKD under hemodialysis were enrolled to the study. We studied the relationship of serum procalcitonin (PTC) and C-reactive protein (CRP) levels (before and after dialysis) with "positive bacterial culture" and "systemic inflammatory response syndrome (SIRS)" results. Sensitivity and specificity were determined by ROC test. Results: Serum PTC before and after dialysis as well as the CRP before dialysis had no significant association with positive bacterial culture (P=0.492, P=0.1 and P=0.268 respectively), however after-dialysis CRP had a significant association with positive bacterial culture (P=0.032). Conclusion: According to the obtained results, it may be concluded that the diagnostic value of serum PTC for diagnosis of positive culture bacterial infections in hemodialysis patients is not satisfactory since the serum CRP level especially after dialysis is more useful.

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Usefulness of serum procalcitonin as a diagnostic biomarker of infection in children with chronic kidney disease

Cited by 13 publications

References 56 publications

Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing

Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing

Maternal serum procalcitonin levels in prediction of chorioamnionitis in women with preterm premature rupture of membranes

Diagnostic value of serum procalcitonin for diagnosis of bacterial infection in patients with chronic kidney disease under hemodialysis

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