Usefulness of sRtot and Rint in bronchodilator testing in the diagnosis of asthma in children

The FOXP3 transcription factor is a marker of regulatory T cells (Tregs), and is essential in the process of their activation and proper expression by promoting immune homeostasis. To assess the influence of the environment on the development of asthma, we hypothesized that in our cohort, exposure to environmental factors is associated with asthma risk in children, and that FOXP3 levels vary with their incidence and are negatively correlated with developing asthma. This prospective study conducted in Poland uses a cohort of 85 children (42 with and 43 without asthma diagnosis) aged 9 to 12 years recruited for the Polish Mother and Child Cohort Study. We collected questionnaires and organized visits to assess patients’ clinical condition (skin prick tests, lung function assessments). Blood samples were taken to determine immune parameters. Breastfed children had lower risk of asthma. Asthma risk was higher in children who live in the city, with antibiotic course before the age of 2 and antibiotic therapy more than twice a year. Environmental factors were associated with childhood asthma. Breastfeeding, the coexistence of other allergic diseases, and the frequency of housekeeping affect FOXP3 levels, which are negatively correlated with the risk of asthma.

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“…Group membership was verified after each visit. Detailed information on the methods employed is given elsewhere [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

The Effect of Environmental Factors on Immunological Pathways of Asthma in Children of the Polish Mother and Child Cohort Study

Sara

Jerzyńska

Podlecka

et al. 2023

IJERPH

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“…Patients underwent spirometry and skin prick tests (SPT), or specific IgE where it was not possible to perform the SPT. Detailed information on the methods employed is given elsewhere [15]. Urine cotinine level was also measured as a marker of tobacco smoke exposure.…”

Section: Child Health Assessmentmentioning

confidence: 99%

Micronutrients and the Risk of Allergic Diseases in School Children

Podlecka

Jerzyńska

Sanad

et al. 2022

IJERPH

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Microelements and vitamins are believed to have immunomodulatory effects. The aim of the study was to establish the role of antioxidants (vitamins A, E, D) and microelements such as copper (Cu), selenium (Se), and zinc (Zn) levels in allergic diseases in schoolchildren. The study uses a cohort of 80 children (40 with and 40 without allergy/asthma diagnosis) aged 9 to 12 years recruited for the Polish Mother and Child Cohort Study. At nine to twelve years old, the children were tested for microelement and vitamin content and health status (including skin-prick test and spirometry, urine cotinine level). Demographic data were collected from mothers by an allergist. The risk of asthma occurrence was found to be significantly related to the levels of Cu and Zn. The level of Cu was also particularly closely associated with allergic rhinitis and was indicated as a significant predictor of food allergy. The levels of Cu and Zn, and poor nutritional status in general, can influence the immune system and may be considered risk factors for developing asthma, allergic rhinitis and food allergy.

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Usefulness of sRtot and Rint in bronchodilator testing in the diagnosis of asthma in children

Cited by 2 publications

References 21 publications

The Effect of Environmental Factors on Immunological Pathways of Asthma in Children of the Polish Mother and Child Cohort Study

The Effect of Environmental Factors on Immunological Pathways of Asthma in Children of the Polish Mother and Child Cohort Study

Micronutrients and the Risk of Allergic Diseases in School Children

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