Usefulness of the BAST-24 smell and taste test in the study of diabetic patients: a new approach to the determination of renal function

Gascón, Cristina; Santaolalla, Francisco; Martı́nez, Agustı́n D.; Rey, Ana Sánchez del

doi:10.3109/00016489.2012.746471

Cited by 23 publications

(44 citation statements)

References 9 publications

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“…Although there was [42]. Although Duda-Sobczak et al [41] found no significant difference between olfactory scores in participants with Type 1 diabetes and control participants, further analysis of data comparing odour identification scores between groups with and without diagnosed microvascular complications showed lower scores in participants with neuropathy and retinopathy.…”

Section: Olfactory Dysfunction and Diabetes Complicationsmentioning

confidence: 96%

“…Most studies have shown that participants with diabetes complications exhibited more olfactory dysfunction than those without complications [14,16,19,42].…”

Section: Olfactory Dysfunction and Diabetes Complicationsmentioning

confidence: 99%

“…In an attempt to examine associations between diabetic kidney disease and olfaction, Gascon et al [42] evaluated the sense of smell in 61 participants with diabetes using the Barcelona Smell Test-24, which consists of 24 chemical odours isolated in individual containers. Although there was [42].…”

Section: Olfactory Dysfunction and Diabetes Complicationsmentioning

confidence: 99%

“…Several hypotheses have been proposed, including microvascular [14,19,42] and macrovascular [13] changes, and central diabetic neuropathy [49], owing to direct damage to the olfactory nerve [16] and/or resulting from other abnormalities of the afferent conduction of stimulus-induced neural impulses, including impairment of ascending subcortical pathways [49] that may occur as a result of diabetes (Fig. 1).…”

Section: Putative Mechanisms For Olfactory Dysfunction In Diabetesmentioning

confidence: 99%

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Association between diabetes mellitus and olfactory dysfunction: current perspectives and future directions

et al. 2017

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The increasing global prevalence of diabetes mellitus presents a significant challenge to healthcare systems today. Although diabetic retinopathy, nephropathy and neuropathy are well-established complications of diabetes, there is a paucity of research examining the impact of dysglycaemia on the olfactory system. Olfaction is an important sense, playing a role in the safety, nutrition and quality of life of an individual, but its importance is often overlooked when compared with the other senses. As a result, olfactory dysfunction is often underdiagnosed. The present review article aims to present and discuss the available evidence on the relationship between diabetes and olfaction. It also explores the associations between olfactory dysfunction and diabetes complications that could explain the underlying pathogenesis. Finally, it summarizes the putative pathological mechanisms underlying olfactory dysfunction in diabetes that require further investigation.

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Section: Olfactory Dysfunction and Diabetes Complicationsmentioning

confidence: 96%

“…Most studies have shown that participants with diabetes complications exhibited more olfactory dysfunction than those without complications [14,16,19,42].…”

Section: Olfactory Dysfunction and Diabetes Complicationsmentioning

confidence: 99%

Section: Olfactory Dysfunction and Diabetes Complicationsmentioning

confidence: 99%

Section: Putative Mechanisms For Olfactory Dysfunction In Diabetesmentioning

confidence: 99%

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Association between diabetes mellitus and olfactory dysfunction: current perspectives and future directions

et al. 2017

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“…This pilot study comprised of 100 Europid Caucasoid patients with T1D, as defined by the National Diabetes Data Group, and 25 patients of them were considered as Diabetic Control (DC) for the complication study [62][63][64][65][66][67] (Table 1 . Patients with overt DNe were identified by the presence of ankle jerk loss, sensations of pain, foot ulcer, and/or autonomic neuropathy.…”

Section: Methodsmentioning

confidence: 99%

Critical Association Study of Olfactory Receptor Gene Polymorphism in Diabetic Complications

Ahmed¹

2014

Immunome Res

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Type I diabetes (TID) is an autoimmune disease (AD) known to trigger retinopathy, neuropathy and nephropathy. Recent findings suggest that numerous pathways are activated during the course of T1D and that these pathways individually or collectively influence progression to Diabetic Nephropathy (DN).A single nucleotide polymorphism (SNP) in the promoter region of the Olfactory Receptor family 14 (OR14) gene, rs9257691, has been shown to be significantly associated with T1D in general. Recent investigations have emphasized on the significance of OR in diabetic complications. In this pilot study, we sought to confirm these findings by investigating the OR14 gene in a group of patients with and without diabetic complications. A hundred patients with (n=75) and without (n=25) different diabetic complications (i.e. Retinopathy (DR), Neuropathy (DNu) and DN) were recruited. Patients with long term ≥ 20 years history of diabetes with no complications were considered as the control group. Case and control subjects were genotyped for OR14 gene adjacent to the Human Leukocyte Antigen (HLA)-F region.The current results showed that the OR14-CC genotype is more significant in patients with DN, p=0.004, in comparison to groups with other complications. No other statistically significant difference was found among male and female groups. In addition, there was no difference in allelic frequencies of cases compared to control subjects. This critical analysis indicates that patients with T1D who have the OR14-CC genotype are significantly susceptible to progressive DN. Screening and identifying diabetic patients at risk for future nephropathy would permit better clinical management. However, a large scale association study is recommended to confirm the above findings.

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Evaluation of olfaction and taste function in type 2 diabetic patients with and without peripheral neuropathy

Yazla

Özmen

Kıyıcı

et al. 2018

Diabetes Metabolism Res

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Usefulness of the BAST-24 smell and taste test in the study of diabetic patients: a new approach to the determination of renal function

Cited by 23 publications

References 9 publications

Association between diabetes mellitus and olfactory dysfunction: current perspectives and future directions

Association between diabetes mellitus and olfactory dysfunction: current perspectives and future directions

Critical Association Study of Olfactory Receptor Gene Polymorphism in Diabetic Complications

Evaluation of olfaction and taste function in type 2 diabetic patients with and without peripheral neuropathy

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