Usefulness of the D-Dimer Concentration as a Predictor of Mortality in Patients With Out-of-Hospital Cardiac Arrest

Szymański, Filip M.; Karpiński, Grzegorz; Filipiak‬, Krzysztof J.; Płatek, Anna E.; Hrynkiewicz−Szymańska, Anna; Kotkowski, Marcin; Opolski, Grzegorz

doi:10.1016/j.amjcard.2013.03.057

Cited by 32 publications

(31 citation statements)

References 23 publications

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“…Recently, Deng et al identified sole D-dimer levels as indicator of immediate mortality in 192 patients with in-hospital cardiac arrest [7]. In a somewhat smaller Polish study, D-dimer was likewise strongly associated with all-cause mortality in out-of-hospital cardiac arrest [35].…”

Section: Practical Implicationsmentioning

confidence: 99%

Added value of the DIC score and of D-dimer to predict outcome after successfully resuscitated out-of-hospital cardiac arrest

Buchtele

Schober

Schoergenhofer

et al. 2018

European Journal of Internal Medicine

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Section: Practical Implicationsmentioning

confidence: 99%

Added value of the DIC score and of D-dimer to predict outcome after successfully resuscitated out-of-hospital cardiac arrest

Buchtele

Schober

Schoergenhofer

et al. 2018

European Journal of Internal Medicine

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“…There is also little known about the long-term outcomes of survivors. 16,17 In our study we examined only patients with cardiac arrest within 12 hours of admission. 11 We present data from almost five years of observation of patients in a cardiac intensive care unit, so this trend is not surprising.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of troponin I and NT-proBNP concentrations in patients after in-hospital cardiac arrest

Płatek

Szymański

Filipiak‬

et al. 2015

Revista Portuguesa de Cardiologia (English Edition)

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Objectives: Cardiac arrest (CA) is a complex event with a dismal survival rate. The aim of this study was to determine whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels measured on admission and serial cardiac troponin I determination in patients with in-hospital cardiac arrest (IHCA) are predictive of 30-day mortality. Methods: Out of 9877 patients hospitalized in the cardiac intensive care unit during the study, we enrolled consecutive patients experiencing cardiac arrest within 12 hours of admission. Baseline characteristics, information about circumstances of CA and cardiopulmonary resuscitation, and initial biochemical parameters were retrospectively collected. Results: A total of 106 patients (61 male, age 71.4±12.6 years) were enrolled. Thirty-four (32.1%) had a history of myocardial infarction, and 13 (12.3%) a history of stroke. Total 30-day mortality was 60.4%. Deceased patients were older (73.7±11.9 vs. 67.8±13.0 years; p=0.01) and had lower systolic (89.4±37.0 vs. 115.0±24.0 mmHg; p=0.0001) and diastolic (53.6±24.8 vs. 66.1±15.0 mmHg; p=0.008) blood pressure on admission. Shockable initial rhythm was more often noted in the survivor group (54.8% vs. 28.1%; p=0.01). Deceased patients had higher median NT-proBNP levels (9590.0 [25---75% interquartile range (IQR), 5640.0---26 450.0] vs. 3190.0 [25---75% IQR, 973.8---5362.5] pg/ml; p=0.02) on admission. There were no differences in the first two troponin I measurements, but values were higher on the third measurement in non-survivors (98.2 [25---75% IQR, 76.4---175.8] vs. 18.7 [25---75% IQR, 5.2---50.6]; p=0.009). A.E. Platek et al. Conclusions: The survival rate of patients after in-hospital CA is poor. Deceased patients have higher NT-proBNP levels on admission, along with higher troponin I concentrations on the third measurement. Those biomarkers are useful in predicting 30-day mortality in IHCA patients. Paragem cardíaca intra-hospitalar; Troponina I; NT-proBNP; Mortalidade Valor prognóstico da troponina I e da concentração de NT-proBNP em doentes após paragem cardíaca intra-hospitalar Resumo Objetivos: A paragem cardíaca (PC) é uma patologia complexa com uma taxa de sobrevivência distal. O objetivo deste estudo foi analisar se a concentração do terminal N do peptídeo natriurético auricular do tipo B (NT-proBNP), medida na admissão, e se a determinação de troponina I cardíaca seriada em doentes com paragem cardíaca intra-hospitalar são fatores preditivos para mortalidade a 30 dias. Métodos: De 9877 doentes hospitalizados durante o estudo na unidade de cuidados intensivos, inscrevemos doentes consecutivos que passaram por paragem cardíaca nas primeiras 12 horas após o internamento. Foram inicialmente recolhidos características basais, informação sobre as circunstâncias da PC, ressuscitação cardiorrrespiratória e parâmetros bioquímicos iniciais. Resultados: Foram inscritos 106 doentes (61 homens, com 71,4±12,6 anos). Trinta e quatro (32,1%) doentes tinham antecedentes de enfarte do miocárdio e 13 (12,3%) antecedentes de acidente vascu...

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“…2 In addition, Szymanski et al reported that the D-dimer concentration measured on arrival was an independent predictor of all-cause mortality in nontraumatic patients with out-of-hospital cardiac arrest. 3 Taking those results into consideration, we focused our attention on acid-base equilibrium and markers of coagulation in patients with emergency situations. Few reports demonstrated coagulation of patients with CPAOA.…”

Section: Discussionmentioning

confidence: 99%

“…2 In addition, Szymanski et al investigated to determine whether the serum D-dimer concentration on arrival was an independent predictor of all-cause mortality in non-traumatic patients with out-of-hospital cardiac arrest and they concluded that the D-dimer concentration was an independent predictor of all-cause mortality. 3 In this study, we analyzed the relationships between the levels of AG, ACAG, FDP, or D-dimer and ROSC in patients with CPA, and investigated the usefulness of FDP and D-dimer levels to predict ROSC compared with AG and ACAG.…”

Section: Introductionmentioning

confidence: 99%

Usefulness of serum fibrin degradation products and D‐dimer levels as biomarkers to predict return of spontaneous circulation in patients with cardiopulmonary arrest on arrival: comparison with acid–base balance

Hagiwara

Murata

Kaneko

et al. 2014

Acute Medicine & Surgery

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Usefulness of the D-Dimer Concentration as a Predictor of Mortality in Patients With Out-of-Hospital Cardiac Arrest

Cited by 32 publications

References 23 publications

Added value of the DIC score and of D-dimer to predict outcome after successfully resuscitated out-of-hospital cardiac arrest

Added value of the DIC score and of D-dimer to predict outcome after successfully resuscitated out-of-hospital cardiac arrest

Prognostic value of troponin I and NT-proBNP concentrations in patients after in-hospital cardiac arrest

Usefulness of serum fibrin degradation products and D‐dimer levels as biomarkers to predict return of spontaneous circulation in patients with cardiopulmonary arrest on arrival: comparison with acid–base balance

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