Usefulness of the endosonography using 25 gauge core needles for immunohistochemistry and molecular testing in lung cancer patients: a feasibility study

Misiaszek, Magdalena; Gnass, Maciej; Rudnicka, Lucyna; Soja, Jerzy; Kużdżał, Jarosław; Szlubowski, Artur

doi:10.20452/pamw.15364

Cited by 1 publication

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“…FNAs from the lung and pleura can be performed with radiological and/or bronchoscopic guidance using 19‐, 21‐, 22‐, or 25‐gauge needles. Thinner needles are associated with less blood contamination while having similar molecular adequacy and success rates compared to thicker needles 8,16,19,20 . ROSE informs the proceduralist when the targeted lesion has been reached, facilitating the collection of adequate material for molecular testing 8,21,22 .…”

Section: Pre‐analytic Considerationsmentioning

confidence: 99%

“…rates compared to thicker needles. 8,16,19,20 ROSE informs the proceduralist when the targeted lesion has been reached, facilitating the collection of adequate material for molecular testing. 8,21,22 A recent survey conducted by the American Society of Cytopathology shows that the practice of ROSE is well accepted by laboratories, but there are considerable variations in its practice.…”

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confidence: 99%

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Molecular cytology of the respiratory tract and pleura

2021

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There is growing evidence that molecular testing is feasible on all types of cytological preparation, which is fortunate as more diagnostic markers and biomarkers for targeted therapies are discovered for use in pulmonary and pleural malignancies. In this article we will discuss the pre‐analytic, analytic, and post‐analytic (interpretive) considerations for successful implementation of molecular tests for diagnostic and predictive markers in respiratory and pleural cytology. The vast majority of laboratories are familiar with, and have validated their molecular protocols for, formalin‐fixed paraffin‐embedded surgical specimens, which are not directly applicable to cytology specimens. Thus, rigorous validation must be performed for each type of fixative and cytology preparation before it is implemented in the clinical setting.

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Section: Pre‐analytic Considerationsmentioning

confidence: 99%