Usefulness of the Endsystolic Quotient and of Fractional Shortening for Assessment of Contractility Changes Under Different Loading Conditions

Heinrich, H.; Fontaine, L; Wilder–Smith, Oliver H.G.; Winter, H.; Ahnefeld, Friedrich Wilhelm

doi:10.1097/00000542-198709001-00209

Cited by 5 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After intravenous administration of 2% lidocaine (2 ml), propofol was infused at a total dose of 2.5 mg.kg −1 , the dose recommended for inducing anaesthesia [15]. An adequate level of anaesthesia was considered as abolition of the eyelash reflex.…”

Section: Methodsmentioning

confidence: 99%

Cardiovascular effects of intravenous propofol administered at two infusion rates: a transthoracic echocardiographic study

Bilotta

Fiorani²,

Rosa

et al. 2001

Anaesthesia

View full text Add to dashboard Cite

SummaryCongenital or acquired forms of the long Q±T syndrome may result in ventricular tachycardia known as torsade de pointes. Many drugs including volatile anaesthetics modify the Q±T interval. Sevoflurane is known to prolong of the rate-corrected Q±T interval (Q±Tc). The objective of this study was to determine whether the sevoflurane-associated Q±Tc prolongation is rapidly reversible when propofol is substituted for sevoflurane. Thirty-two female patients were allocated to two groups. All patients received sevoflurane induction and anaesthesia for 15 min. In one group, sevoflurane was then discontinued and anaesthesia maintained on propofol for another 15 min. The second group received sevoflurane anaesthesia for 30 min. Measurements were taken before, and 15, 20, 25 and 30 min after induction. Q±Tc prolongation was significantly reduced 5, 10 and 15 min after propofol had been substituted for sevoflurane. We conclude that the sevoflurane-associated Q± Tc prolongation is fully reversible within 15 min when propofol is substituted for sevoflurane. Long Q±T syndromes represent ECG-abnormalities that may result in recurrent syncopal attacks and sudden death due to ventricular tachyarrhythmia known as torsade de pointes [1]. These abnormalities may be caused by mutated genes encoding for myocardial sodium and potassium ion channels (congenital long Q±T syndrome, CLQTS), metabolic or electrolyte abnormalities, or by drugs (acquired long Q±T syndrome, ALQTS). The CLQTS is based on a malfunction of ion channels at the myocardial cell membrane, resulting in an inadequate outflow of potassium or excessive inflow of sodium [2]. Prolongation of myocardial repolarisation delays the inactivation of calcium channels resulting in late calcium inflow, which in turn contributes to the formation of early after-depolarisations (EADs) [2]. EADs may reach threshold amplitude and trigger ventricular arrhythmia [2, 3]. Many factors contribute to the development of ALQTS. Hypokalaemia [4], age and sex [5], obesity [6], and many drugs have been shown to be associated with a prolonged Q±T interval [2]. Among the drugs currently used in anaesthesia, volatile anaesthetics are known to alter the Q±T interval. Prolongation of the Q±T interval by isoflurane [7, 8] and sevoflurane [9] and shortening of the Q±T interval by halothane has been already described [7, 8]. It has also been reported that induction of anaesthesia using propofol tends to shorten the Q±Tc interval in patients with an already prolonged Q±Tc interval [10]. Prolongation of Q±Tc by sevoflurane in such patients is alarming and may force the anaesthetist to consider an alternative anaesthetic.The aim of this study was to determine whether intraoperative sevoflurane-associated Q±Tc prolongation can rapidly be reversed when propofol is substituted for sevoflurane. MethodsAfter approval of the institutional ethics committee and after obtaining written informed consent, 32 otherwise Only women were selected, as women are per se prone to a prolonged Q±T interval [11]. Patien...

show abstract

Section: Methodsmentioning

confidence: 99%

Cardiovascular effects of intravenous propofol administered at two infusion rates: a transthoracic echocardiographic study

Bilotta

Fiorani²,

Rosa

et al. 2001

Anaesthesia

View full text Add to dashboard Cite

show abstract

Systolic Pressure-Dimension Relationships and Diastolic Dimensions for Monitoring of Left Ventricular Function

Heinrich¹

1989

Transesophageal Echocardiography

View full text Add to dashboard Cite

Systolic Pressure-Dimension Relationship in the Assessment of Left Ventricular Function

Heinrich¹

1988

Update 1988

View full text Add to dashboard Cite

Usefulness of the Endsystolic Quotient and of Fractional Shortening for Assessment of Contractility Changes Under Different Loading Conditions

Cited by 5 publications

References 0 publications

Cardiovascular effects of intravenous propofol administered at two infusion rates: a transthoracic echocardiographic study

Cardiovascular effects of intravenous propofol administered at two infusion rates: a transthoracic echocardiographic study

Systolic Pressure-Dimension Relationships and Diastolic Dimensions for Monitoring of Left Ventricular Function

Systolic Pressure-Dimension Relationship in the Assessment of Left Ventricular Function

Contact Info

Product

Resources

About