Usefulness of the Geriatric Nutritional Risk Index to predict the severity of cholecystitis among older patients in the emergency department

Lee, Jong Seok; Jeong, Ki Young; Ko, Seok Hoon

doi:10.1111/ggi.13900

Cited by 6 publications

(1 citation statement)

References 29 publications

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“…The GNRI is calculated using serum albumin levels and the ratio of current body weight to ideal body weight. The GNRI is associated with prognosis in hemodialysis patients and those with heart failure and cholecystitis [6][7][8][9][10]. In addition, the relationship between the GNRI and prognostic outcomes in patients with malignancies was recently reported [11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 97%

Geriatric nutritional risk index predicts cancer prognosis in patients with local advanced rectal cancer undergoing chemoradiotherapy followed by curative surgery

Ide

Okugawa

Omura

et al. 2020

Preprint

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Aim: The clinical significance of the geriatric nutritional risk index (GNRI) in locally advancer rectal cancer (LARC) patients undergoing preoperative chemoradiotherapy (CRT) followed by curative surgery has not been comprehensively evaluated. Methods: This retrospective study enrolled 93 LARC patients diagnosed with clinical lymph node metastasis. The GNRI formula was as follows: 1.489×albumin (g/dl)+41.7×current weight/ideal weight. Patients were categorized as GNRI low (GNRI <104.25) or high (GNRI >104.25) according to the receiver operating characteristic (ROC) curve for survival analysis. The impact of GNRI status on the prognostic outcomes of curative surgery for LARC was examined. Results: There were 55 (59.14%) and 3841 (40.86%) patients in the GNRI high and low groups, respectively. Of the investigated demographic factors, age, clinical tumor invasion, C-reactive protein (CRP)/albumin ratio (CAR), prognostic nutritional index (PNI) and modified Glasgow Prognostic Score (mGPS) were significantly associated with the GNRI value. In Kaplan–Meier analysis, overall survival (OS) and disease-free survival (DFS) were significantly shorter in the GNRI low group (OS: p=0.00020, DFS: p=0.0044, log-rank test). Multivariate analysis using a Cox proportional hazards model showed that a low GNRI was an independent risk factor for poor OS [hazard ratio (HR) =3.22; 95% confidence interval (CI), 1.37–8.23; p=0.0068) and DFS (HR=2.32; 95%CI=1.15-4.79; p=0.018). Additionally, for patients with pathological lymph node metastasis [ypN(+)], those with a low GNRI showed shorter OS and DFS (OS: p=0.033, DFS: p=0.032, log-rank test).Conclusions: GNRI is a useful marker for LARC patients diagnosed with clinical lymph node metastasis and treated by preoperative CRT followed by curative surgery.

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Section: Introductionmentioning

confidence: 97%

Geriatric nutritional risk index predicts cancer prognosis in patients with local advanced rectal cancer undergoing chemoradiotherapy followed by curative surgery

Ide

Okugawa

Omura

et al. 2020

Preprint

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Prognostic impact of malnutrition in patients with coronary artery disease: a systematic review and meta-analysis

He,

Huang,

et al. 2023

Nutrition Reviews

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Context Conflicting predictions of malnutrition for the long-term prognosis of coronary artery disease (CAD) exist. Objective This study aimed to investigate the relationship between malnutrition and long-term prognosis of patients with CAD. Data Sources Four databases were searched for articles from February 11, 1936, to September 10, 2022. Data Extraction Cohort studies adjusting for multiple cardiovascular risk factors with data on CAD and malnutrition were included. Malnutrition was measured and defined by different nutritional evaluation tools. The hazard ratios (HRs) and confidence intervals (CIs) for all-cause mortality and major adverse cardiovascular events (MACEs) were synthesized. Subgroup analyses were performed based on study design, assessment tools, ethnicity/race, follow-up, sample size, and types of CAD. Meta-regression was used to compare whether the effect sizes of the 2 subgroups were statistically significant. Data Analysis A total of 30 cohort studies were included, totaling 81 361 participants with CAD. Nutritional evaluation tools, including the Geriatric Nutritional Risk Index (GNRI), Controlling Nutritional Status (CONUT), Nutritional Risk Screening 2002, Mini-Nutritional Assessment, and Prognostic Nutritional Index, were used. Malnutrition increased all-cause mortality (HR = 1.72; 95% CI: 1.53, 1.93) and MACEs (HR = 1.47; 95% CI: 1.35, 1.60) in patients with CAD. Subgroup analysis revealed the results were consistent across study design, ethnicity/race, follow-up, sample size, and types of CAD. Subgroup analyses and meta-regression revealed that malnutrition was associated with a higher risk of all-cause mortality (HR = 2.26; 95% CI: 1.91, 2.68) and MACEs (HR = 2.28; 95% CI: 1.69, 3.08) in patients with stable CAD than those with other types of CAD. Meta-regression revealed that the GNRI (HR = 2.20; 95% CI: 1.65, 2.93) was more effective than CONUT (HR = 1.47; 95% CI: 1.21, 1.78) in predicting all-cause mortality. Conclusion Malnutrition independently increased all-cause mortality by 72% and MACEs by 47% in patients with CAD, especially with stable CAD. The GNRI is a more effective nutritional evaluation tool than CONUT in predicting all-cause mortality.

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Effect of Preoperative Geriatric Nutritional Risk Index on Prognosis in Patients after Surgery for Lower Gastrointestinal Perforation

Hasegawa,

Sanmoto

2024

Ann Nutr Metab

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Introduction: Geriatric Nutritional Risk Index (GNRI) is a reliable index derived from serum al-bumin levels, height, and weight. Although various prognostic factors have been studied, the effect of preoperative nutritional status on surgical outcomes remains unexplored. This study aimed to evaluate the efficacy of the GNRI in predicting postoperative outcomes of lower gastro-intestinal perforation. Methods: Eighty patients treated at our institution between January 2016 and December 2022 were retrospectively analyzed. This study primarily focused on the correlation between pre-operative GNRI and two key outcomes: postoperative hospital stay duration and 1-year mortality rate. Results: Our findings revealed a significant association between low GNRI scores and increased 1-year mortality (Odd ratio 4.0, 95% confidence interval [CI] 1.1–16, p=0.025). Kaplan–Meier analysis and log-rank test showed that patients in the low GNRI group had markedly poorer overall survival rates than those in the high GNRI group (12-month survival rate 0.88 [95%CI: 0.75–0.95] vs. 0.65 [95%CI: 0.47–0.78]; p=0.018). Additionally, both univariate and multivariate analyses indicated that lower GNRI scores were associated with prolonged hospital stays. Conclusion: We showed that a low GNRI score was associated with high mortality and pro-longed hospital stay after emergency surgery for lower gastrointestinal perforation.

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Usefulness of the Geriatric Nutritional Risk Index to predict the severity of cholecystitis among older patients in the emergency department

Cited by 6 publications

References 29 publications

Geriatric nutritional risk index predicts cancer prognosis in patients with local advanced rectal cancer undergoing chemoradiotherapy followed by curative surgery

Geriatric nutritional risk index predicts cancer prognosis in patients with local advanced rectal cancer undergoing chemoradiotherapy followed by curative surgery

Prognostic impact of malnutrition in patients with coronary artery disease: a systematic review and meta-analysis

Effect of Preoperative Geriatric Nutritional Risk Index on Prognosis in Patients after Surgery for Lower Gastrointestinal Perforation

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