Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity

Yılmaz, Hikmet; Uçan, Bekir; Sayki, Müyesser; Ünsal, İlknur Öztürk; Şahi̇n, Mustafa; Özbek, Mustafa; Delibaşı, Tuncay

doi:10.1016/j.dsx.2014.04.009

Cited by 60 publications

(45 citation statements)

References 32 publications

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“…This is evident because subjects with obesity and diabetes, which are the main risk factors for NAFLD, show higher average NLR in relation to controls (68, 73), and among patients with morbid obesity, the mean NLR values were significantly higher in those who developed type 2 diabetes (T2DM) than those who did not (mean 4.11 vs. 3.46, P < 0.001) (73), showing that a higher inflammatory states precedes both (NAFLD and T2DM) obesity-related outcomes.…”

Section: The Role Of Cellular Immune Imbalances In Nafldmentioning

confidence: 99%

Immune Imbalances in Non-Alcoholic Fatty Liver Disease: From General Biomarkers and Neutrophils to Interleukin-17 Axis Activation and New Therapeutic Targets

Paquissi

2016

Front. Immunol.

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Non-alcoholic fatty liver disease (NAFLD) is an increasing problem worldwide and is associated with negative outcomes such as cirrhosis, hepatocellular carcinoma, insulin resistance, diabetes, and cardiovascular events. Current evidence shows that the immune response has an important participation driving the initiation, maintenance, and progression of the disease. So, various immune imbalances, from cellular to cytokines levels, have been studied, either for better compression of the disease pathophysiology or as biomarkers for severity assessment and outcome prediction. In this article, we performed a thorough review of studies that evaluated the role of inflammatory/immune imbalances in the NAFLD. At the cellular level, we gave special focus on the imbalance between neutrophils and lymphocytes counts (the neutrophil-to-lymphocyte ratio), and that which occurs between T helper 17 (Th17) and regulatory T cells as emerging biomarkers. By extension, we reviewed the reflection of these imbalances at the molecular level through pro-inflammatory cytokines including those involved in Th17 differentiation (IL-6, IL-21, IL-23, and transforming growth factor-beta), and those released by Th17 cells (IL-17A, IL-17F, IL-21, and IL-22). We gave particular attention to the role of IL-17, either produced by Th17 cells or neutrophils, in fibrogenesis and steatohepatitis. Finally, we reviewed the potential of these pathways as new therapeutic targets in NAFLD.

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Section: The Role Of Cellular Immune Imbalances In Nafldmentioning

confidence: 99%

Immune Imbalances in Non-Alcoholic Fatty Liver Disease: From General Biomarkers and Neutrophils to Interleukin-17 Axis Activation and New Therapeutic Targets

Paquissi

2016

Front. Immunol.

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“…7,8 In the literature, few studies showed that NLR was meaningful for the diagnosis of diabetes and for the prediction of development of diabetic complications. 9,10 Whether or not NLR can predict the prognosis in diabetic foot infection is unclear. Therefore, the aim of this study was to investigate any relations between the NLR and the development of osteomyelitis and the need for amputation in patients with DFI.…”

Section: Introductionmentioning

confidence: 99%

Can Ratio of Neutrophil-Tolymphocyte Count and Erythrocyte Sedimentation Rate in Diabetic Foot Infection Predict Osteomyelitis and/or Amputation?

et al. 2017

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The aim of this study was to search for any relations between the neutrophil-to-lymphocyte ratio (NLR) and the development of osteomyelitis and the need for amputation in patients with diabetic foot infection (DFI). All data included DFI patients who were hospitalized in our Infectious Diseases Clinic between 2012 and 2015 and who were classified according to International Classification Disease Code System. 75 patients were analyzed in the study. The DFI patients were stratified into 3 groups of whom had amputation procedure, whom had only debridement/drainage procedure and whom had any surgery procedure. Sidac post hoc analysis was used to perform the effects of NLR, C-reactive protein, erythrocyte sedimentation rate and glycosylated hemoglobin on the surgery procedure status. The DFI patients were also stratified into two another separate group for another analysis to search for the effect of NLR values on the development of osteomyelitis. The mean value of NLR in the amputated patients’ group (15.7±10.3 was significantly higher than those with debridement procedure (9.9±5.6) and those without any surgery (6.0±2.8) (P=0.001). NLR values were also found significantly higher in patients with osteomyelitis in the second analysis (P=0.004). In this study, the NLR was found to have a predictive value on the development of osteomyelitis and on the progression to amputation in patients with DFI.

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“…8 In particular, high NLR levels, reflecting a worsening of the inflammatory process, seems to be tightly related with a poor prognosis for COVID-19 patients. 9 Of note this index, emerging as a useful biomarker in several chronic inflammatory disorders and neoplastic diseases, appears to be markedly increased also in the elderly, 10 diabetic subjects, 11 hypertension 12 , and obese subjects, 13 who represent the categories of the population identified as at higher risk of experiencing more serious COVID-19 infection and fatal outcomes.…”

mentioning

confidence: 99%

NKG2A and COVID-19: another brick in the wall

et al. 2020

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Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity

Cited by 60 publications

References 32 publications

Immune Imbalances in Non-Alcoholic Fatty Liver Disease: From General Biomarkers and Neutrophils to Interleukin-17 Axis Activation and New Therapeutic Targets

Immune Imbalances in Non-Alcoholic Fatty Liver Disease: From General Biomarkers and Neutrophils to Interleukin-17 Axis Activation and New Therapeutic Targets

Can Ratio of Neutrophil-Tolymphocyte Count and Erythrocyte Sedimentation Rate in Diabetic Foot Infection Predict Osteomyelitis and/or Amputation?

NKG2A and COVID-19: another brick in the wall

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