Usefulness of the Neutrophil-to-Lymphocyte Ratio in Predicting Short- and Long-Term Mortality in Breast Cancer Patients

Azab, Basem; Bhatt, Vijaya Raj; Phookan, Jaya; Murukutla, Srujitha; Kohn, Nina; Terjanian, Terenig; Widmann, Warren D.

doi:10.1245/s10434-011-1814-0

Cited by 519 publications

(449 citation statements)

References 24 publications

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“…In this study we found that 57 Several studies reported the relationship between increased NLR and worse prognostic outcomes in various cancers including breast, colorectal and hepatocellular carcinomas, as well as, several urinary malignancies including prostate, bladder and renal cell carcinomas (RCC). [9][10][11][12][13][14] Proctor et al [15] performed a Scottish Cancer Registry review across 11 different malignancies, including 8759 patients, and noted a significantly increased risk of cancer-specific (HR=1.76) and overall mortality (HR=1.77) in patients with a preoperative NLR>5. Our results could not demonstrate the presence of any significant relationship between the NLR and PFS or CSS.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of preoperative neutrophil-to-lymphocyte ratio on the prognosis of germ cell testicular tumors

Bolat

Aydoğdu

Polat

et al. 2017

Turkish Journal of Urology

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Objective: We investigated the prognostic value of preoperative neutrophil-to-lymphocyte ratio (NLR) on germ cell testicular tumors (GCT). Material and methods:The data of 53 patients who underwent inguinal orchiectomy were analyzed retrospectively. NLR was calculated from the preoperative complete blood cell counts. Receiver operating characteristic (ROC) analysis was performed to find the threshold values for NLR. Correlations between cancer-specific survival (CSS) and progression-free survival (PFS) and NLR were evaluated. Results:The mean follow-up time was 23.55±18.06 months. The mean level of NLR was 3.08±1.81. Optimal threshold values of NLR was calculated as 3.55 for PFS (area under curve, AUC: 0.55) and 3.0 for CSS (AUC: 0.66). For patients with a NLR of <3.55 and NLR of ≥3.55, mean times-to-progression were 55.71 months (95% CI, 51.27-60.14) and 51.95 months (95% CI, 38.02-65.87, p= 0.152), respectively. As well as, for patients with a NLR of <3.0 and NLR of ≥3.0, mean times -to-cancer specific death were 54.72 months (95% CI, 49.05-60.38) and 49.43 months (95% CI, 37.64-61.22, p= 0.119), respectively. Conclusion:Preoperative NLR is not a useful tool to predict the prognosis of patients with GCT.

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Section: Discussionmentioning

confidence: 99%

Predictive value of preoperative neutrophil-to-lymphocyte ratio on the prognosis of germ cell testicular tumors

Bolat

Aydoğdu

Polat

et al. 2017

Turkish Journal of Urology

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“…After that, emerging evidences from several studies have pointed out that NLR has a prognostic value in patients with pancreatic (Aliustaoglu et al, 2010), breast (Azab et al, 2012), lung (Kaya et al, 2013;Unal et al, 2013) and gastric (Jung et al, 2011) cancers. Recent literature has relatively fewer papers that focused on the significance of the pre-treatment NLR in CRC.…”

Section: Discussionmentioning

confidence: 99%

Pretreatment Neutrophil/Lymphocyte Ratio as a Prognostic Aid in Colorectal Cancer

Özdemi̇r¹,

Akın²,

Sücüllü³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Larger platelets are more metabolically and enzymatically active than smaller platelets (Mangalpally et al, 2010). Recently, elevated preoperative or pretreatment NLR, PLR and MPV detected in peripheral blood have been identified in various cancers, including colon cancer, esophageal cancer, gastric cancer ovarian cancer and breast cancer (Walsh et al, 2005;Gwak et al, 2007;Smith et al, 2009;Sharaiha et al, 2011;Thavaramara et al, 2011;Azab et al, 2012;Kilincalp et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Elevated Serum Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios Could be Useful in Lung Cancer Diagnosis

Kemal

Yücel²,

Ekiz³

et al. 2014

Asian Pacific Journal of Cancer Prevention

110

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Background: Lung cancer (LC) is still the primary cause of cancer deaths worldwide, and late diagnosis is a major obstacle to improving lung cancer outcomes. Recently, elevated preoperative or pretreatment neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) detected in peripheral blood were identified as independent prognostic factors associated with poor survival with various cancers, including colon cancer, esophageal cancer, gastric cancer and breast cancer. Objective: The aim of this study was to examine whether MPV, NLR and PLR could be useful inflammatory markers to differentiate lung cancer patients from healthy controls. An investigation was also made of the relationship between these markers and other prognostic factors and histopathological subgroups. Materials and Methods: Retrospectively eighty-one lung cancer patients and 81 age-sexes matched healthy subjects included into the study. Patients with hypertension, hematological and renal disease, heart failure, chronic infection, hepatic disorder and other cancer were excluded from the study. The preoperative or pretreatment blood count data was obtained from the recorded computerized database. Results: NLR and PLR values were significantly higher in the LC patients compared to the healthy subjects.( NLR: 4.42 vs 2.45 p=0.001, PLR: 245.1 vs 148.2 p=0.002) MPV values were similar in both groups (7.7 vs 7.8). No statistically significant relationship was determined between these markers (MPV, NLR and PLR) and histopathological subgroups and TNM stages. Conclusions: NLR and PLR can be useful biomarkers in LC patients before treatment. Larger prospective studies are required to confirm these findings.

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Usefulness of the Neutrophil-to-Lymphocyte Ratio in Predicting Short- and Long-Term Mortality in Breast Cancer Patients

Abstract: NLR is an independent predictor of short- and long-term mortality in breast cancer patients with NLR > 3.3. We suggest prospective studies to evaluate the NLR as a simple prognostic test for breast cancer.

Cited by 519 publications

References 24 publications

Predictive value of preoperative neutrophil-to-lymphocyte ratio on the prognosis of germ cell testicular tumors

Predictive value of preoperative neutrophil-to-lymphocyte ratio on the prognosis of germ cell testicular tumors

Pretreatment Neutrophil/Lymphocyte Ratio as a Prognostic Aid in Colorectal Cancer

Elevated Serum Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios Could be Useful in Lung Cancer Diagnosis

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