Usefulness of thermographic analysis to control temperature homogeneity in the development and implementation of a closed recirculating CO₂ chemohyperthermia model

Abstract

To control homogeneity of temperature distribution is feasible using infra-red digital images in a closed HIPEC with CO recirculation.

Safety and Effectiveness of Perioperative Hyperthermic Intraperitoneal Chemotherapy with Gemcitabine in Patients with Resected Pancreatic Ductal Adenocarcinoma: Clinical Trial EudraCT 2016-004298-41

“…As a result of this study, our group initiated the first randomized clinical trial to determine the approaches to the use of this therapy in pancreatic ductal cancer. The model we performed was a closed technique characterized by recirculation of the drug gemcitabine (120 mg/m 2 ) in a hyperthermic solution called Physioneal 40 for 30 min with CO 2 agitation and controlled temperature between 41-42 • C. In this way enhances the tissue penetration of chemotherapy and minimizes heat loss and the risk of contamination [36][37][38][39][40][41][42][43][44][45][46][47][48].…”

Safety of perioperative hyperthermic intraperitoneal chemotherapy with gemcitabine in patients with resected pancreatic adenocarcinoma: a pilot study of the clinical trial EudraCT 2016-004298-41

“…For the second problem, the increase of abdominal pressure in a HIPEC closed system, our group considered that this morbidity could increase after using CO 2 to create turbulence during HIPEC to achieve better drug distribution. However, we have demonstrated in the experimental models and clinical pilot study that using a closed HIPEC technique with CO 2 recirculation, even with a laparoscopic approach, after performing cytoreductive surgery for peritoneal metastases is possible and safe, with an efficacy equal to that of conventional methods (34)(35)(36)(37)(38)(39)(40).…”

Prophylactic surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC CO2) versus standard surgery in colorectal carcinoma at high risk of peritoneal carcinomatosis: short-term and long-term outcomes from the CHECK study – protocol for a randomised, multicentre, phase 3 trial

“…29 Based on continuous CO2 infusion to generate turbulence during HIPEC and overcome the distribution issues of the closed abdomen technique, it has given fair safety and efficacy outcomes. [30][31][32] Hence, whether and how the optimisation of surgery and the HIPEC technique for CRCs can ever achieve the results obtained in gynaecology is still debate.…”