Usefulness of Tissue Doppler Imaging for Assessing Left Ventricular Filling Pressure in Patients With Stable Severe Systolic Heart Failure

Gellen, Barnabas; Canouï‐Poitrine, Florence; Lesault, Pierre‐François; Thuaut, Aurélie Le; Lim, Pascal; Guéret, Pascal; Guendouz, Soulef; Pongas, Dionyssis; Teiger, Emmanuel; Dubois‐Randé, Jean‐Luc; Hittinger, Luc; Damy, Thibaud

doi:10.1016/j.amjcard.2013.07.019

Cited by 16 publications

(5 citation statements)

References 25 publications

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“…Our analyses demonstrated that the degree of SD was the dominant prognostic driver in these patients, but DD had a major modifying effect, rendering it an important research issue and potential therapeutic target. Our findings are consistent with but extend previous reports such as the Heart Failure and a Controlled Trial Investigating Outcomes of Exercise Training (HF‐ACTION) trial and a few smaller studies . Because patients with SD were investigated, we focus in the discussion below on the differential prognostic utility of DD in SD.…”

Section: Discussionsupporting

confidence: 89%

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Prognostic impact of diastolic dysfunction in systolic heart failure—A cross‐project analysis from the German Competence Network Heart Failure

Lüers

Edelmann

Wachter

et al. 2017

Clinical Cardiology

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Background We investigated the modifying role and prognostic importance of diastolic dysfunction (DD) in patients with heart failure and systolic dysfunction (SD). Hypothesis The echocardiographic evaluation of diastolic function in patients with SD provides further prognostic information. Methods From the German Competence Network Heart Failure, 1046 heart failure patients with reduced left ventricular ejection fraction (LVEF; <50%) were echocardiographically studied and followed for a median of 5 years. SD was subdivided into nonsevere (LVEF 36%–49%) and severe (LVEF ≤35%); DD was subdivided into nonsevere (E/E′ <15) and severe (E/E′ ≥15). Results In general, severe SD was associated with higher hazard ratios (HRs; 2‐fold to 3.5‐fold) for all endpoints (all‐cause death, cardiac death, cardiovascular hospitalization, duration of hospitalization). Patients with severe SD had a 2.5‐fold risk of death (95% confidence interval [CI]: 1.84‐3.47, P < 0.001), and patients with severe DD showed a 1.8‐fold risk (95% CI: 1.17‐2.61, P = 0.004). Furthermore, we observed a strong interaction of SD and DD: concomitant severe DD in patients with moderate SD increased risk substantially (HR: 1.73, 95% CI: 1.16‐2.6, P = 0.007); by contrast, in patients with severe SD, additional presence of severe DD added little or no risk (HR for interaction: 0.5–1.2). Conclusions In heart failure patients with reduced LVEF, the evaluation of diastolic function provides additional prognostic information. Although severe SD generally increased the risk for all endpoints, the degree of DD and its impact as a prognostic marker for overall and cardiovascular mortality appeared of particular relevance in subjects with nonsevere SD.

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Section: Discussionsupporting

confidence: 89%

“…Our findings are consistent with but extend previous reports such as the Heart Failure and a Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) trial and a few smaller studies. 21,22 Because patients with SD were investigated, we focus in the discussion below on the differential prognostic utility of DD in SD.…”

Section: Discussionmentioning

confidence: 99%

Prognostic impact of diastolic dysfunction in systolic heart failure—A cross‐project analysis from the German Competence Network Heart Failure

Lüers

Edelmann

Wachter

et al. 2017

Clinical Cardiology

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“…Tissue Doppler imaging can be used for an estimation of LV filling pressure. It has been shown that the E/e 0 ratio correlates significantly with invasive pulmonary capillary wedge pressure (25,26). An E/e 0 ratio !…”

Section: Discussionmentioning

confidence: 99%

Prevalence of diastolic dysfunction in patients with ankylosing spondylitis: a cross-sectional study

Sveälv

Tang

Klingberg

et al. 2014

Scandinavian Journal of Rheumatology

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“…13 E/e 0 ratio has shown good predictive value of LV filling pressures in patients with septic shock, 16 although some controversies remain in patients with heart failure and severe LV systolic dysfunction. [17][18][19] Many studies report TDI variables according to survival in septic patients but with conflicting results. We aimed to investigate the predictive value for survival between these two TDIderived variables in patients with severe sepsis and/or septic shock.…”

mentioning

confidence: 99%

Tissue Doppler assessment of diastolic function and relationship with mortality in critically ill septic patients: a systematic review and meta-analysis

Sanfilippo

Corredor

Arcadipane

et al. 2017

British Journal of Anaesthesia

124

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Usefulness of Tissue Doppler Imaging for Assessing Left Ventricular Filling Pressure in Patients With Stable Severe Systolic Heart Failure

Cited by 16 publications

References 25 publications

Prognostic impact of diastolic dysfunction in systolic heart failure—A cross‐project analysis from the German Competence Network Heart Failure

Prognostic impact of diastolic dysfunction in systolic heart failure—A cross‐project analysis from the German Competence Network Heart Failure

Prevalence of diastolic dysfunction in patients with ankylosing spondylitis: a cross-sectional study

Tissue Doppler assessment of diastolic function and relationship with mortality in critically ill septic patients: a systematic review and meta-analysis

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