Usefulness of tissue transglutaminase type 2 antibodies in early pregnancy

Abstract

Celiac disease (CD), an autoimmune disease triggered by dietary gluten, is a multi-systemic disorder that primarily results in mucosal damage of the small intestine. Reproductive disorders and pregnancy complications have been associated with CD. Conflicting results have been published concerning CD and the risk of impaired fetal growth with reduced birthweight. The aim of our multicentric, perspective, case-control study was to determine the prevalence of undiagnosed CD in mothers of small for gestational age (SGA) newborns in two regions of Italy. The study included 480 mothers: group A consisted of 284 SGA newborns' mothers and group B consisted of 196 appropriate for gestational age (AGA) newborns' mothers. Tissue transglutaminase type 2 antibodies (TG2) IgA and IgG were measured in blood samples. We diagnosed two new cases of CD in asymptomatic mothers. It may be appropriate to include the TG2 to the panel of prenatal blood test.

Bullous Dermatoses in Pregnancy

“…TG2 antibodies IgA and IgG measured in blood samples identified two new cases of CD in asymptomatic SGA mothers. The authors suggested including the TG2 to the panel of prenatal blood test [46]. 5) with interruption in untreated pregnant DH patients under normal diet with severe skin symptoms, although the first choice is the GFD, a dapsone treatment promptly improves the skin symptoms, as a safety level C drug (Table 2).…”