Usefulness of triple-phase thallium-201 SPECT in non-small-cell lung cancer (NSCLC): association with proliferative activity

Abstract

The super-delayed scan in the triple-phase (201)Tl SPECT is more useful than conventional delayed scan for both the diagnostic capability and assessing proliferation of NSCLC.

Quantitative 201thallium scintigraphy for prediction of histological response to neoadjuvant chemotherapy in osteosarcoma; systematic review and meta-analysis

“…Ilhan et al described that late images reflect more of the active cellular uptake or retention and less of the extravascular components than early images, which is in line with our results [27]. Moreover, Fujita et al described that the super-delayed scan (24 h) in the triple-phase 201 Tl single-photon emission computed tomography (SPECT) is more useful than early image (15 min) and conventional delayed image (4 h) for both the diagnostic capability and assessing proliferation of non-smallcell lung cancer [30]. Further studies are required to measure the optimal intervals between 201 Tl injection and image acquisition.…”

PAMAM Dendrimer‐Based Nanodevices for Nuclear Medicine Applications

“…A variety of radionuclides, such as gallium‐67 ( 67 Ga), iodine‐123 ( 123 I), 131 I, 99m Tc, indium‐111 ( 111 In) and thallium‐201 ( 201 TI), can emit appropriate γ‐radiation for SPECT imaging applications. In an earlier study, Kojima et al monitored the local retention of several polymers including acetylated dendrimer (Ac‐den‐DTPA) and collagen peptide‐conjugated dendrimer (CP‐den‐DTPA) by noninvasive SPECT imaging through labeling with radioactive 111 In.…”

PET and SPECT Imaging of Tumor Proliferation

“…The association between 201 Tl uptake and tumor cell proliferation has also been reported. [183][184][185][186][187] …”