As one of the most important design tasks of building design, space layout design affects the building energy performance (BEP). In order to investigate the effect, a literature review of relevant papers was performed. Ten relevant articles were found and reviewed in detail. First, a methodology for studying the effects of space layouts on BEP were proposed regarding design variables, energy indicators and BEP calculation methods, and the methodologies used in the 10 articles were reviewed. Then, the effects of space layouts on energy use and occupant comfort were analysed separately. The results show that the energy use for heating, cooling, lighting and ventilation is highly affected by space layouts, as well as thermal and visual comfort. The effects of space layouts on energy use are higher than on occupant comfort. By changing space layouts, the resulting reductions in the annual final energy for heating and cooling demands were up to 14% and 57%, respectively, in an office building in Sweden. The resulting reductions in the lighting demand of peak summer and winter were up to 67% and 43%, respectively, for the case of an office building in the UK, and the resulting reduction in the air volume supplied by natural ventilation was 65%. The influence of other design parameters, i.e., occupancy and window to wall ratio, on the effects of space layouts on BEP was also identified.Sustainability 2020, 12, 1829 2 of 23 sufficient daylight and natural ventilation within a building, the building is expected to require less energy demand in total.Although architectural space layout is expected to highly affect BEP, it is rarely included in the studies on energy-efficient building design. Numerous studies exist on energy-efficient design, and most of them focus on geometry [11,14], envelope [15,16], façade [17,18], material [19,20], atrium [21,22] and shading systems [23,24]. On the other hand, researchers have been working on space layout design for decades [25,26]; however, they mainly focused on other design objectives rather than energy performance. These objectives include safety [27,28], logistics [29,30], efficiency [31,32], finance cost [33,34], occupant health and performance [35,36], view connection [37,38] and acoustics [39,40]. These two research domains, space layout design and energy-efficient building design, are shown in Figure 1. The overlapping area of the two domains, i.e., energy-efficient space layout design, is the focus of this paper. This paper aims at the effects on BEP caused by changing space layouts, without considering the possible influence on the indirect cost of the building, such as space usability and workability.