With the increasing penetration of digital technologies into health management, digital health interventions in workplaces have been subject to substantial interest. These interventions aim to enhance employee well-being, minimize absenteeism and presenteeism, and augment organizational productivity. This paper carries out a systematic review focusing on the key characteristics of effective digital health interventions designed to enhance health-related outcomes within workplace settings and evaluates their implications for prospective implementation in the workplace. According to PRISMA guidelines, the current systematic review adopted the most appropriate methods to retrieve studies from PubMed, covering interventions that included cognitive-behavioral therapy apps, software that reduces sedentary behaviors, virtual reality for well-being, and comprehensive health programs. The studies’ quality was assessed through standardized tools with a preference for randomized control trials and mixed-methods research. It was found that digital health interventions positively impact mental health, physical activity, and well-being. However, limitations were found due to self-reported data and potential biases. This review identified long-term effectiveness, objective outcome measures, and cost-effectiveness as areas for future research. Digital health interventions hold promise in enhancing workplace health strategies, as they offer scalable, personalized, cost-effective solutions. However, critically relevant research gaps have to be faced to integrate these successfully and exploit their real potential in organizational health strategies.