Background and AimsEducation and providing self‐care skills are essential for patients with chronic respiratory disease. Today, the use of information and communication technologies has provided many opportunities for facilitating self‐care in chronic patients. In this regard, the attention of researchers has been shifted toward the design and use of mobile phone‐based technologies for self‐care purposes in patients with chronic obstructive pulmonary disease (COPD). In this study, a protocol is proposed for the design, implementation, and evaluation of a mobile‐based self‐care application for patients with COPD.MethodsThe design science approach will be used in the design, implementation, and evaluation of the self‐care application. This solution‐oriented paradigm goes beyond the level of description and explanation and takes steps toward problem‐solving. One of the most common models of design science is the waterfall model of information technology development. The seven consecutive stages of the waterfall model include preliminary analysis, system analysis, design, programming, testing, implementation, and maintenance/modification.ConclusionThe present protocol is the first to design, implement, and evaluate a mobile‐based self‐care application for patients with COPD in Iran. The integration of new technologies for the self‐care education of COPD patients is considered an innovative strategy. This application is designed based on the self‐care needs of COPD patients, which will ultimately promote the self‐care activities of patients.