This document describes the online leaderboard public evaluation program, Open Media Forensics Challenge (OpenMFC) 2021-2022. OpenMFC is the annual evaluation open to public participants worldwide to support research and help advance the state of the art for imagery (i.e., images and videos) forensics technologies. Participation is free. NIST does not provide funds to participants.To facilitate development of systems that can automatically detect and locate manipulations in imagery, OpenMFC releases a series of media forensics development and evaluation datasets to support different evaluation tasks. The evaluation is being conducted to examine the performance of system's accuracy and robustness over diverse datasets. The participants can visualize their system performance on an online leaderboard evaluation platform.In the OpenMFC 2020-2021 evaluation, 59 participants registered to participate in the program, and 224 public researchers worldwide received MFC datasets. Since 2016, NIST has released MFC dataset to more than 500 individuals and 200 organizations from 26 countries and regions worldwide.In the report, first, the introduction, objectives, challenges, contributions, and achievements of the evaluation program are covered and discussed in the Section 1. Second, the evaluation website, tasks, datasets, and the leaderboard interface are described in the Section 2. The participants' system performance results are also presented in this section. Third, the community engagements, findings, and public participants' difficulties are summarized in the Section 3. Then, two new studies for the next year evaluation, OpenMFC 2021-2022, are introduced in the same section. After that, the solutions to help public participants and the OpenMFC 2021-2022 work plan are proposed in the Section 4. Finally, the potential impacts are discussed in the Section 5.