Using 18F-FDG microPET imaging to measure the inhibitory effects of Clematis chinensis Osbeck on the pro-inflammatory and degradative mediators associated with inflammatory arthritis

Clematichinenoside AR induces immunosuppression involving Treg cells in Peyer׳s patches of rats with adjuvant induced arthritis

“…According to the traditional Chinese medicinal view, the nature and flavor of Radix Clematidis are pungent, salty and warm, and channel tropism shows that Radix Clematidis acts on the urinary bladder meridian (State Pharmacopoeia Committee of People's Republic of China, 2010). Accumulative evidence has demonstrated that saponins extracted from Clematidis Radix possess anti-inflamatory (Fu et al, 2010;Shi et al, 2006) and chondroprotective (Hsieh et al, 2011;Wu et al, 2013Wu et al, , 2010 properties, and clematichinenoside AR (AR) has been isolated and identified as the major active component of triterpenoid saponins Ma et al,2009;Zhou et al, 2012).…”

Chemical and biological research of Clematis medicinal resources

“…Multiple triterpene saponins of C. chinensis showed the potential anti-inflammatory activity with inhibitory activities against COX-1 and COX-2 enzymes [8]. Saponins might be responsible for the inhibition effects of C. chinensis on the pro-inflammatory and degradative mediators associated with inflammatory arthritis [9]. The saponin fraction from this plant showed the therapeutic effect on monosodium iodoacetate induced osteoarthritis via sheltering articular cartilage [10].…”

Chemical and biological research of Clematis medicinal resources

“…Multiple triterpene saponins of C. chinensis showed the potential anti-inflammatory activity with inhibitory activities against COX-1 and COX-2 enzymes (Fu et al, 2010). mediators associated with inflammatory arthritis (Hsieh et al, 2011). mediators associated with inflammatory arthritis (Hsieh et al, 2011).…”