Using 24 factorial designs optimization of repaglinide gastroretentive drug delivery system

Ramu, B.; Chandrul, Kaushal K.; Pandiyan, P. Shanmuga

doi:10.5958/0974-360x.2021.00126.8

Cited by 10 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Formula for result calculation is: Percent Elongation = Final Length of Patch/Initial length x 100 Penetration study: Skin penetration study of micro needle patch was performed by using para lm by following reported method [20]. The Para lm was folded into eight folds.…”

Section: Methodsmentioning

confidence: 99%

Formulation and Evaluation of Microneedle Patch Raloxifene for Transdermal Drug Delivery

SUPRIYA,

KAMERE,

VIJAYKUMAR

2024

Preprint

View full text Add to dashboard Cite

Micro needle patches are the novel dosage form in transdermal drug delivery systems with improved penetration to skin. In this study we fabricated micro needle patches containing Raloxifene an immunosuppressant drug by using polymer thiolated chitosan that in turn was developed by adding thiol group to chitosan. These micro needle patches were further evaluated for their mechanical, physical and chemical parameters. The optimized micro needle patch having 225 needles with 665 µm length, 90 µm width showed good penetration i.e 84% and better percent elongation. In-vitro and ex-vivo penetration studies on rat skin using Franz diffusion cell showed sustained release of (85%) Raloxifene in its comparative study with Raloxifene ointment. HPLC analysis also showed 91.7% release of drug from optimized formulation of micro needle patch. Finally the recent progress proved that micro needle patches of thiolated chitosan loaded with Raloxifene for transdermal drug delivery have the potential to show therapeutic outcomes with improved bioavailability and sustained release of drug over a longer period.

show abstract

Section: Methodsmentioning

confidence: 99%

Formulation and Evaluation of Microneedle Patch Raloxifene for Transdermal Drug Delivery

SUPRIYA,

KAMERE,

VIJAYKUMAR

2024

Preprint

View full text Add to dashboard Cite

show abstract

“…As a result, less water is reabsorbed from the collecting ducts, boosting urine output by increasing the osmolarity in the lumen. It is frequently used to treat hypertension, congestive heart failure, symptoms of edema, and to prevent kidney stones [12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Analytical Method Development and Validation of Propranolol and Hydrochlorothiazide

Golchha,

B.Rajkamal

2024

Preprint

View full text Add to dashboard Cite

The active pharmaceutical components of Propranolol and Hydrochlorothiazide in their bulk dosage forms were to be measured using a unique, straightforward, responsive, and stable RP- HPLC method that was being developed and gradually validated. For the quantitative determination of Propranolol and Hydrochlorothiazide, a straightforward, specific, verified, and well-defined stability that exhibits gradient RP-HPLC approach has been developed. The Waters C18 column (150mm×4.6mm, 5mm particle size) was used for the chromatographic method, which involved isocratic elution with a mobile phase made up of orthophosphoric acid (0.1%) and acetonitrile (40:60% v/v). The instrument parameters called for a flow rate of 1 ml/min and a detection wavelength of 265 nm using the UV detector. The chromatographic method was expedited using the impurity-spiked solution. The proposed method's validity was examined in accordance with the international conference on harmonization (ICH) guidelines. The plotted calibration charts had linear regression coefficients of 0.999, indicating that their linearity was within acceptable bounds. The suggested approach is quick, easy, practical, and reasonably priced. It can be used for routine manufacturing sample analysis during stability tests and to confirm the caliber of medication samples during stability studies.

show abstract

“…Reduction of total dose administered and minimization of administration frequency leading to better patient compliances [2,3].Both single and multiple unit systems have been developed, the single unit oating system is more popular but has the disadvantage that its purpose would not be achieved if it fails to oat, or is rapidly emptied from the stomach since there is high variability of gastrointestinal transit time [4]. On the other hand, a oating system made up of multiple units may be better suited because they are claimed to reduce intersubject variability in absorption and also lower the probability of dose dumping [5]. Floating microspheres are non-effervescent gastro retentive drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Design and Chracterization of Prazosin Hcl Hydrogel Drug Delivery system

P.Roopasri,

V.Anjaneyullu,

VIJAYKUMAR

2024

Preprint

View full text Add to dashboard Cite

The purpose of the present study was to get the floating microspheres of Prazosin hydrochloride and to sustain the drug to overcome the side effects as postural hypotension.A central composite design based on the response surface method was used.The preparations were made by emulsion-solvent evaporation method.In this study, a three-factors, three levels Central composite design with drug-polymer ratio (X1), Solvent ratio (X2) and Speed (X3) as independent variables were chosen for the formulation. The microspheres were evaluated for physicochemical parameters as shape, size, buoyancy percentage and drug entrapment efficiency. SEM studies showed good topology of microspheres. The cumulative % drug release of optimized formulation after 24 hours was 99.87%. Model fitting analysis revealed the release pattern followed Korsmeyer.The results demonstrated a good relationship between the predicted and experimental values, supporting the validity of the model.FTIR and DSC studies showed that there was no interaction between drug and polymers. The optimized formulation was found to be stable when subjected to accelerated stability studies. The results obtained indicated that response surface methodology may be successfully used to analyze the effect of formulation variables and develop an optimized formulation thereby reducing the severaltrials, time and cost of formulation development.

show abstract

Using 24 factorial designs optimization of repaglinide gastroretentive drug delivery system

Cited by 10 publications

References 0 publications

Formulation and Evaluation of Microneedle Patch Raloxifene for Transdermal Drug Delivery

Formulation and Evaluation of Microneedle Patch Raloxifene for Transdermal Drug Delivery

Analytical Method Development and Validation of Propranolol and Hydrochlorothiazide

Design and Chracterization of Prazosin Hcl Hydrogel Drug Delivery system

Contact Info

Product

Resources

About