The purpose of this research was to ensure that the leaves of multi-leaf collimator (MLC) move along the trajectory set in the radiotherapy plan. Aiming at the characteristics of multileaf control of multi-leaf collimator, the model of leaf control system is established. Taking the synchronized error between leaves as the input of the system, combined with PD CCC and PD ILC, an iterative learning control strategy based on cross-coupled is proposed, and verified by experiments, then compared with the multi-leaf control strategy that adopts iterative learning control algorithm independently. The experimental results show that the control strategy proposed in this study can reduce the synchronized error between leaves, and the initial value of the maximum absolute value of the error proposed reduces the synchronous position error of the leaves from the beginning, which meets the requirements of radiation therapy. The results provide a guarantee for the synchronous control of MLC to improve the efficiency of conformal radiotherapy.