“…(1) Difficult to collect: Increasing challenges in sourcing sufficient suitable natural teeth, probably as a result of improvement in health standards; it is time-consuming and requires a large number of teeth (wisdom teeth, teeth with highly complex root canal morphology and with previous root canal treatment are not acceptable, and natural teeth must present complete root development, an intact crown and intact roots) [19,23,24,27,30,35,37]. Nowadays, the biobank is considered a primary resource for the development of precision medicine.…”